PCDGL_HUMAN - dbPTM
PCDGL_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID PCDGL_HUMAN
UniProt AC Q9Y5F7
Protein Name Protocadherin gamma-C4
Gene Name PCDHGC4
Organism Homo sapiens (Human).
Sequence Length 938
Subcellular Localization Cell membrane
Single-pass type I membrane protein.
Protein Description Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain..
Protein Sequence MLRKVRSWTEIWRWATLLFLFYHLGYVCGQIRYPVPEESQEGTFVGNVAQDFLLDTDSLSARRLQVAGEVNQRHFRVDLDSGALLIKNPIDREALCGLSASCIVPLEFVTEGPLEMYRAEVEIVDVNDHAPRFPRQQLDLEIGEAAPPGQRFPLEKAQDADVGSNSISSYRLSSNEHFALDVKKRSDGSLVPELLLEKPLDREKQSDYRLVLTAVDGGNPPRSGTAELRVSVLDVNDNAPAFQQSSYRISVLESAPAGMVLIQLNASDPDLGPSGNVTFYFSGHTPDRVRNLFSLHPTTGKLTLLGPLDFESENYYEFDVRARDGGSPAMEQHCSLRVDLLDVNDNAPYITVTSELGTLPESAEPGTVVALISVQDPDSGSNGDVSLRIPDHLPFALKSAFRNQFSLVTAGPLDREAKSSYDIMVTASDAGNPPLSTHRTIFLNISDVNDNPPSFFQRSHEVFVPENNRPGDLLCSLAASDPDSGLNALISYSLLEPRNRDVSASSFISLNPQTGAVHATRSFDYEQTQTLQFEVQARDRGNPPLSSTVTVRLFVLDLNDNAPAVLRPRARPGSLCPQALPPSVGAGHLITKVTAVDLDSGYNAWVSYQLLEAPDPSLFAVSRYAGEVRTAVPIPADLPPQKLVIVVKDSGSPPLSTSVTLLVSLEEDTHPVVPDLRESSAPREGESRLTLYLAVSLVAICFVSFGSFVALLSKCLRGAACGVTCFPAGTCACLTRSRRREGLPPSNGILRIQLGSDDPIKFVDVGGHSHGCTPLASAPTRSDSFMMVKSPSAPMAGEPVRPSCPPSDLLYGLEQAPPNTDWRFSQAQRPGTSGSQNGDDTGTWPNNQFDTEMLQAMILASASEAADGSSTLGGGAGTMGLSARYGPQFTLQHVPDYRQNVYIPGSNATLTNAAGKRDGKAPAGGNGNKKKSGKKEKK
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
206PhosphorylationPLDREKQSDYRLVLT
CCCHHCCCCCEEEEE		47.9125072903
208PhosphorylationDREKQSDYRLVLTAV
CHHCCCCCEEEEEEE		15.8725072903
213PhosphorylationSDYRLVLTAVDGGNP
CCCEEEEEEEECCCC		19.7025072903
265N-linked_GlycosylationGMVLIQLNASDPDLG
EEEEEEEECCCCCCC		22.48UniProtKB CARBOHYD
276N-linked_GlycosylationPDLGPSGNVTFYFSG
CCCCCCCCEEEEECC		33.71UniProtKB CARBOHYD
298PhosphorylationNLFSLHPTTGKLTLL
HHHCCCCCCCEEEEE		37.1224275569
444N-linked_GlycosylationTHRTIFLNISDVNDN
CCCEEEEEHHHCCCC		22.44UniProtKB CARBOHYD
546PhosphorylationDRGNPPLSSTVTVRL
HCCCCCCCCEEEEEE		29.7219690332
547PhosphorylationRGNPPLSSTVTVRLF
CCCCCCCCEEEEEEE		34.2819690332
548PhosphorylationGNPPLSSTVTVRLFV
CCCCCCCEEEEEEEE		19.4719690332
550PhosphorylationPPLSSTVTVRLFVLD
CCCCCEEEEEEEEEE		10.4519690332
746PhosphorylationRREGLPPSNGILRIQ
CCCCCCCCCCEEEEE		45.83-
773PhosphorylationGGHSHGCTPLASAPT
CCCCCCCCCCCCCCC		26.4023532336
782PhosphorylationLASAPTRSDSFMMVK
CCCCCCCCCCEEEEE		39.8329759185
790PhosphorylationDSFMMVKSPSAPMAG
CCEEEEECCCCCCCC		16.8129759185
825PhosphorylationPNTDWRFSQAQRPGT
CCCCCCCCCCCCCCC		18.9425003641
885PhosphorylationTMGLSARYGPQFTLQ
CCCCCCCCCCCEEEE		32.6425884760
890PhosphorylationARYGPQFTLQHVPDY
CCCCCCEEEEECCCC		21.9124961811
897PhosphorylationTLQHVPDYRQNVYIP
EEEECCCCCCCEEEC		14.1824927040
902PhosphorylationPDYRQNVYIPGSNAT
CCCCCCEEECCCCCE		14.6725884760
906PhosphorylationQNVYIPGSNATLTNA
CCEEECCCCCEECCC		20.2424719451
909PhosphorylationYIPGSNATLTNAAGK
EECCCCCEECCCCCC		38.0627050516
916UbiquitinationTLTNAAGKRDGKAPA
EECCCCCCCCCCCCC		42.4632142685
920UbiquitinationAAGKRDGKAPAGGNG
CCCCCCCCCCCCCCC		56.3332142685
929UbiquitinationPAGGNGNKKKSGKKE
CCCCCCCCCCCCCCC		64.0832142685
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of PCDGL_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of PCDGL_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of PCDGL_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of PCDGL_HUMAN !!
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of PCDGL_HUMAN

loading...

Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions.";
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.;
Sci. Signal. 2:RA46-RA46(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-546; SER-547 ANDTHR-548, AND MASS SPECTROMETRY.

TOP
© 2024 Institute of Bioinformatics and Systems Biology, NYCU | Designed by : BiOmics Laboratory