LNX1_MOUSE - dbPTM
LNX1_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID LNX1_MOUSE
UniProt AC O70263
Protein Name E3 ubiquitin-protein ligase LNX
Gene Name Lnx1
Organism Mus musculus (Mouse).
Sequence Length 728
Subcellular Localization Cytoplasm.
Protein Description E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of NUMB. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates ubiquitination of isoform p66 and isoform p72 of NUMB, but not that of isoform p71 or isoform p65.; Isoform 2 provides an endocytic scaffold for IGSF5/JAM4..
Protein Sequence MNQPDLADDPDPSPEPLCIVCGQNHSPEENHFYTYTEDVDDDLICHICLQALLDPLDTPCGHTYCTLCLTNFLVEKDFCPVDRKPVVLQHCKKSSILVNKLLNKLLVTCPFTEHCTEVLQRCDLQHHFQTSCKGASHYGLTKDRKRRSQDGCPDGCASLMATTLSPEVSAAATISLMTDEPGLDNPAYVSSVEDGEPVANSSDSGRSNRTRARPFERSTMRSRSFKKINRALSALRRTKSGSVVANHVDQGRDNSENTTVPEVFPRLFHLIPDGEITSIKINRADPSESLSIRLVGGSETPLVHIIIQHIYRDGVIARDGRLLPGDIILKVNGMDISNVPHNYAVRLLRQPCQVLRLTVLREQKFRSRSNAHVPDSYGPRDDSFHVILNKSSPEEQLGIKLVRRVDEPGVFIFNVLNGGVADRHGQLEENDRVLAINGHDLRFGSPESAAHLIQASERRVHLVVSRQVRQSSPDIFQEAGWISNGQQSPGPGERNTASKPAATCHEKVVSVWKDPSESLGMTVGGGASHREWDLPIYVISVEPGGVISRDGRIKTGDILLNVNGIELTEVSRTEAVAILKSAPSSVVLKALEVKEQEAQEDCSPAALDSNHNVTPPGDWSPSWVMWLELPQYLCNCKDVILRRNTAGSLGFCIVGGYEEYSGNKPFFIKSIVEGTPAYNDGRIRCGDILLAVNGRSTSGMIHACLARMLKELKGRITLTIASWPGTFL
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
240PhosphorylationSALRRTKSGSVVANH
HHHHHCCCCCEEECC		35.3728973931
242PhosphorylationLRRTKSGSVVANHVD
HHHCCCCCEEECCCC		22.1028973931
287PhosphorylationKINRADPSESLSIRL
EEECCCCCCCEEEEE		40.1229472430
289PhosphorylationNRADPSESLSIRLVG
ECCCCCCCEEEEEEC		31.5829472430
291PhosphorylationADPSESLSIRLVGGS
CCCCCCEEEEEECCC		18.2329472430
445PhosphorylationGHDLRFGSPESAAHL
CEECCCCCHHHHHHH		23.84-
581O-linked_GlycosylationEAVAILKSAPSSVVL
HHHHHHHHCCCHHHH		41.8030016717
584O-linked_GlycosylationAILKSAPSSVVLKAL
HHHHHCCCHHHHHHH		35.1730016717
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of LNX1_MOUSE !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of LNX1_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of LNX1_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
CLD1_MOUSECldn1physical
19295125
ERBB2_MOUSEErbb2physical
16122940
NUMB_HUMANNUMBphysical
9535908
LNX1_MOUSELnx1physical
9535908
RB6I2_MOUSEErc1physical
27889896
LIPA3_MOUSEPpfia3physical
27889896
ERC2_MOUSEErc2physical
27889896
CARL1_MOUSELrrc16aphysical
27889896
FCSD2_MOUSEFchsd2physical
27889896
FERM2_MOUSEFermt2physical
27889896
LIPA2_MOUSEPpfia2physical
27889896
KPCG_MOUSEPrkcgphysical
27889896
NDRG3_MOUSENdrg3physical
27889896
2A5G_MOUSEPpp2r5cphysical
27889896
LIS1_MOUSEPafah1b1physical
27889896
NDEL1_MOUSENdel1physical
27889896
SPKAP_MOUSESphkapphysical
27889896
KAP0_MOUSEPrkar1aphysical
27889896
EAA1_MOUSESlc1a3physical
27889896
KLH11_MOUSEKlhl11physical
27889896
PP2BA_MOUSEPpp3caphysical
27889896
KAP1_MOUSEPrkar1bphysical
27889896
KCC2D_MOUSECamk2dphysical
27889896
NDRG2_MOUSENdrg2physical
27889896
TRIM9_MOUSETrim9physical
27889896
CYFP1_MOUSECyfip1physical
27889896
1433G_MOUSEYwhagphysical
27889896
KAZRN_MOUSEKaznphysical
27889896
IQEC1_MOUSEIqsec1physical
27889896
WASF1_MOUSEWasf1physical
27889896
DGCR8_MOUSEDgcr8physical
27889896
HS71B_MOUSEHspa1bphysical
27889896
CL16A_MOUSEClec16aphysical
27889896
UN13B_MOUSEUnc13bphysical
27889896
SRGP1_MOUSESrgap1physical
27889896
HNRH1_MOUSEHnrnph1physical
27889896
CTND2_MOUSECtnnd2physical
27889896
MIO_MOUSEMiosphysical
27889896
EFTU_MOUSETufmphysical
27889896
PHLB1_MOUSEPhldb1physical
27889896
1433Z_MOUSEYwhazphysical
27889896
SNP47_MOUSESnap47physical
27889896
HS74L_MOUSEHspa4lphysical
27889896
1433B_MOUSEYwhabphysical
27889896
K1C15_MOUSEKrt15physical
27889896
TCPB_MOUSECct2physical
27889896
SRCN1_MOUSESrcin1physical
27889896
1433T_MOUSEYwhaqphysical
27889896
K1C13_MOUSEKrt13physical
27889896
TCPR1_MOUSETecpr1physical
27889896
PFKAL_MOUSEPfklphysical
27889896
HECAM_MOUSEHepacamphysical
27889896
CAMP1_MOUSECamsap1physical
27889896
VMA5A_MOUSEVwa5aphysical
27889896
ADDA_MOUSEAdd1physical
27889896
LIPB1_MOUSEPpfibp1physical
27889896
C170B_MOUSECep170bphysical
27889896
SYWC_MOUSEWarsphysical
27889896
AP1B1_MOUSEAp1b1physical
27889896
NDRG1_MOUSENdrg1physical
27889896
DTNA_MOUSEDtnaphysical
27889896
LDB1_MOUSELdb1physical
27889896
GSTM7_MOUSEGstm7physical
27889896
CTNA2_MOUSECtnna2physical
27889896
TBCE_MOUSETbcephysical
27889896
AT12A_MOUSEAtp12aphysical
27889896
CDK14_MOUSECdk14physical
27889896
ENTP2_MOUSEEntpd2physical
27889896
BCR_MOUSEBcrphysical
27889896
CTTB2_MOUSECttnbp2physical
27889896
NPTN_MOUSENptnphysical
27889896
SC6A1_MOUSESlc6a1physical
27889896
RPN1_MOUSERpn1physical
27889896
ATLA1_MOUSEAtl1physical
27889896
CTNB1_MOUSECtnnb1physical
27889896
SRGP2_MOUSESrgap2physical
27889896
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of LNX1_MOUSE

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Related Literatures of Post-Translational Modification

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