KLH11_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: KLH11_MOUSE
• UniProt AC: Q8CE33
• Protein Name: Kelch-like protein 11
• Gene Name: Klhl11
• Organism: Mus musculus (Mouse).
• Sequence Length: 709
• Protein Description: Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, leading most often to their proteasomal degradation..
• Protein Sequence: MAAAVAAAAAAAAAAASFQVLEMESMETAVAGSASLAAEVRGSGTVDFVTGAGISTLVDTGGSDPGPEAEDFECSTHCSELSWRQNEQRRQGLFCDITLCFGGAGGREFRAHRSVLAAATEYFTPLLSGQFSESRSGRVEMRKWSSEPGPEPDTVEAVIEYMYTGRIRVSTGSVHEVLELADRFLLIRLKEFCGEFLKKKLHLSNCVAIHSLAHMYTLSQLALKAADMIRRNFYKVIQDEEFYTLPFHLIRDWLSDLEITVDSEEVLFETVLKWVQRNAEERERYFEELFKLLRLSQMKPTYLTRHVKPERLVANNEVCVKLVAEAVERHALRAENIQSGTLQQPTSQVSLLPRYGQNMDVIMVIGGVSEGGDYLSECVGYFVDEDRWVNLPHIHNHLDGHAVAITESYVYVAGSMEPGFAKTVERYNPNLNTWEHVCSLMTRKHSFGLTEVKGKLYSIGGHGNFSPGFKDVTVYNPELDKWHNLESAPKILRDVKALAIEDRFVYIAARTPVDRDTEDGLKAVITCYDTETRQWQDVESLPLIDNYCFFQMSVVNSNFYQTASCCPKSYSLENEEAVRKIAGQVSDEILESLPPEVLSIEGAAICYYRDDVFIIGGWKNSDDIDKQYRKEAYRYCAERKRWMLLPPMPQPRCRATACHVRIPYRYLHGTQRYPMPQNLMWQKDRIRQMQEIHRHALNMRRVPSSQIEC

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
453	Ubiquitination	SFGLTEVKGKLYSIG CCCCEEEECEEEEEC	44.06	-
455	Ubiquitination	GLTEVKGKLYSIGGH CCEEEECEEEEECCC	38.24	-
466	Phosphorylation	IGGHGNFSPGFKDVT ECCCCCCCCCCCEEE	28.28	-
481	Ubiquitination	VYNPELDKWHNLESA EECCCHHHCCCCCHH	64.08	-
522	Ubiquitination	RDTEDGLKAVITCYD CCCCCCEEEEEEEEE	46.25	-
673	Phosphorylation	YLHGTQRYPMPQNLM HCCCCCCCCCCCCHH	8.28	-
704	Phosphorylation	LNMRRVPSSQIEC-- HHHCCCCHHHCCC--	31.83	24759943
705	Phosphorylation	NMRRVPSSQIEC--- HHCCCCHHHCCC---	29.16	24759943

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of KLH11_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of KLH11_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of KLH11_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of KLH11_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.