dbPTM

PHLB1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	PHLB1_MOUSE
UniProt AC	Q6PDH0
Protein Name	Pleckstrin homology-like domain family B member 1
Gene Name	Phldb1
Organism	Mus musculus (Mouse).
Sequence Length	1371
Subcellular Localization
Protein Description
Protein Sequence	MDPLNRSQLGPGCKTQAVVQKGPLDLIETGQGLKVQTDKPHLVSLGSGRLSTAITLLPLEEGRTVIGSAARDISLQGPGLAPEHCYIENLRGTLTLYPCGNACTIDGLPVRQPTRLTQGCMLCLGQSTFLRFNHPAEAKWMKSMIPAGVRAPGPTYNPGSAESESLVNGNHTAQPATRAPSACASHSSLVSSIEKDLQEIMDSLVLEEPGAAGKKPAATSPLSPMANGGRYLLSPPTSPGAMSVGSSYENTSPAFSPLSSPASSGSCASHSPSGQEPGPSVPPLVPARSSSYHLALQPPQSRPSGSRSSDSPRLGRKGGHERPPSPGLRGLLTDSPAATVLAEARRTTESPRLGGQLPVVAISLSEYPSSGARSQPASIPGSPKFQSPVPAPRNKIGTLQDRPPSPFREPPGTERVLTSSPSRQLVGRTFSDGLAATRTLQPPESPRLGRRGLDSMRELPPLSPSLSRRALSPLPARTAPDPKLSREVAESPRPRRWAAHGTSPEDFSLTLGARGRRTRSPSPTLGESLAPRKGSFSGRLSPAYSLGSLTGASPRQSPRAQRKLSSGDLRVPIPRERKNSITEISDNEDELLEYHRRQRQERLREQEMERLERQRLETILNLCAEYSRADGGPETGELPSIGEATAALALAGRRPSRGLAGAIVVSGRCGEESGGASQRLWESMERSDEENLKEECSSTESTQQEHEDAPGAKHQGEVLAVEEERAQVLGRVEQLKIRVKELEQQLQEAAREAEMERALLQGEREAERASLQKEQRAVDQLQEKLVALETGIQKDRDKEADALETETKLFEDLEFQQLERESRVEEERELAGQGLLRSKAELLRSVSKRKERLAVLDSQAGQIRAQAVQESERLAREKNAALQLLQKEKEKLNVLERRYHSLTGGRPFPKTTSTLKEMEKLLLPAVDLEQWYQELMSGLGTGLAAASPRSSPPPLPAKASRQLQVYRSKMDSDAASPLPRTRSGPLPSSSGSSSSSSQLSVATLGRSPSPKSALLAQNGTSSLPRNLAATLQDIETKRQLALQQKGHQVIEEQRRRLAELKQKAAAEAQCQWDALHGAGPFSAGPSGFPALMHHSILHHLPAGRERGEEGEHAYDTLSLESSDSMETSISTGGNSACSPDNMSSASGLDMGKIEEMEKMLKEAHAEKSRLMESREREMELRRQALEEERRRREQVERRLQSESARRQQLVEKEVKLREKQFSQARPLTRYLPNRKEDFDLKTHIESSGHGVDTCLHVVLSSKVCRGYLIKMGGKIKSWKKRWFVFDRLKRTLSYYVDKHETKLKGVIYFQAIEEVYYDHLRSAAKSPNPALTFCVKTHDRLYYMVAPSAEAMRIWMDVIVTGAEGYTQFMN

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
44	Phosphorylation	TDKPHLVSLGSGRLS CCCCCEEEECCCCCC	33.11	26060331
47	Phosphorylation	PHLVSLGSGRLSTAI CCEEEECCCCCCCEE	26.49	26060331
51	Phosphorylation	SLGSGRLSTAITLLP EECCCCCCCEEEEEE	17.90	26824392
52	Phosphorylation	LGSGRLSTAITLLPL ECCCCCCCEEEEEEC	27.03	25162660
55	Phosphorylation	GRLSTAITLLPLEEG CCCCCEEEEEECCCC	21.56	29233185
131	Asymmetric dimethylarginine	LGQSTFLRFNHPAEA ECCCHHHHCCCHHHH	26.57	-
131	Methylation	LGQSTFLRFNHPAEA ECCCHHHHCCCHHHH	26.57	24129315
185	Phosphorylation	RAPSACASHSSLVSS CCCCHHHCCHHHHHH	24.64	25338131
188	Phosphorylation	SACASHSSLVSSIEK CHHHCCHHHHHHHHH	27.63	25338131
191	Phosphorylation	ASHSSLVSSIEKDLQ HCCHHHHHHHHHHHH	30.78	26643407
192	Phosphorylation	SHSSLVSSIEKDLQE CCHHHHHHHHHHHHH	27.56	26824392
219	Phosphorylation	AGKKPAATSPLSPMA CCCCCCCCCCCCCCC	32.74	25521595
220	Phosphorylation	GKKPAATSPLSPMAN CCCCCCCCCCCCCCC	21.08	21659605
223	Phosphorylation	PAATSPLSPMANGGR CCCCCCCCCCCCCCC	18.93	27087446
292	Phosphorylation	VPARSSSYHLALQPP CCCCCCCEEEEECCC	11.64	29514104
311	Phosphorylation	SGSRSSDSPRLGRKG CCCCCCCCCCCCCCC	17.54	29550500
325	Phosphorylation	GGHERPPSPGLRGLL CCCCCCCCCCCCHHC	33.99	25521595
333	Phosphorylation	PGLRGLLTDSPAATV CCCCHHCCCCHHHHH	39.20	26643407
335	Phosphorylation	LRGLLTDSPAATVLA CCHHCCCCHHHHHHH	15.94	26824392
339	Phosphorylation	LTDSPAATVLAEARR CCCCHHHHHHHHHHH	20.40	23984901
374	Phosphorylation	YPSSGARSQPASIPG CCCCCCCCCCCCCCC	39.73	27087446
378	Phosphorylation	GARSQPASIPGSPKF CCCCCCCCCCCCCCC	35.68	27087446
382	Phosphorylation	QPASIPGSPKFQSPV CCCCCCCCCCCCCCC	21.40	25521595
387	Phosphorylation	PGSPKFQSPVPAPRN CCCCCCCCCCCCCCC	30.88	26824392
405	Phosphorylation	TLQDRPPSPFREPPG CCCCCCCCCCCCCCC	39.08	26824392
413	Phosphorylation	PFREPPGTERVLTSS CCCCCCCCCEECCCC	26.79	23737553
418	Phosphorylation	PGTERVLTSSPSRQL CCCCEECCCCCCCHH	25.05	22324799
419	Phosphorylation	GTERVLTSSPSRQLV CCCEECCCCCCCHHC	35.77	24453211
420	Phosphorylation	TERVLTSSPSRQLVG CCEECCCCCCCHHCC	22.97	26824392
422	Phosphorylation	RVLTSSPSRQLVGRT EECCCCCCCHHCCCC	34.31	22324799
429	Phosphorylation	SRQLVGRTFSDGLAA CCHHCCCCCCCCCHH	22.89	25521595
431	Phosphorylation	QLVGRTFSDGLAATR HHCCCCCCCCCHHCC	30.10	27087446
437	Phosphorylation	FSDGLAATRTLQPPE CCCCCHHCCCCCCCC	20.69	28066266
439	Phosphorylation	DGLAATRTLQPPESP CCCHHCCCCCCCCCC	25.95	27087446
445	Phosphorylation	RTLQPPESPRLGRRG CCCCCCCCCCCCCCC	22.54	25521595
455	Phosphorylation	LGRRGLDSMRELPPL CCCCCCHHHHHCCCC	25.45	29514104
463	Phosphorylation	MRELPPLSPSLSRRA HHHCCCCCHHHCCHH	20.44	25521595
465	Phosphorylation	ELPPLSPSLSRRALS HCCCCCHHHCCHHCC	35.28	27087446
467	Phosphorylation	PPLSPSLSRRALSPL CCCCHHHCCHHCCCC	24.86	25619855
472	Phosphorylation	SLSRRALSPLPARTA HHCCHHCCCCCCCCC	24.33	23527152
491	Phosphorylation	LSREVAESPRPRRWA CCHHHHHCCCCCCCC	19.24	26824392
502	Phosphorylation	RRWAAHGTSPEDFSL CCCCCCCCCHHHHCE	31.10	26745281
503	Phosphorylation	RWAAHGTSPEDFSLT CCCCCCCCHHHHCEE	30.77	21659605
508	Phosphorylation	GTSPEDFSLTLGARG CCCHHHHCEEECCCC	32.53	26824392
510	Phosphorylation	SPEDFSLTLGARGRR CHHHHCEEECCCCCC	23.19	25619855
514	Methylation	FSLTLGARGRRTRSP HCEEECCCCCCCCCC	37.03	24129315
518	Phosphorylation	LGARGRRTRSPSPTL ECCCCCCCCCCCCCC	33.85	25521595
520	Phosphorylation	ARGRRTRSPSPTLGE CCCCCCCCCCCCCCC	29.17	18388127
522	Phosphorylation	GRRTRSPSPTLGESL CCCCCCCCCCCCCCC	31.59	18388127
524	Phosphorylation	RTRSPSPTLGESLAP CCCCCCCCCCCCCCC	52.30	25521595
528	Phosphorylation	PSPTLGESLAPRKGS CCCCCCCCCCCCCCC	28.21	27742792
535	Phosphorylation	SLAPRKGSFSGRLSP CCCCCCCCCCCCCCC	21.19	27087446
537	Phosphorylation	APRKGSFSGRLSPAY CCCCCCCCCCCCCCC	25.38	21082442
541	Phosphorylation	GSFSGRLSPAYSLGS CCCCCCCCCCCCHHH	13.21	26824392
544	Phosphorylation	SGRLSPAYSLGSLTG CCCCCCCCCHHHCCC	14.07	20469934
545	Phosphorylation	GRLSPAYSLGSLTGA CCCCCCCCHHHCCCC	28.49	27087446
548	Phosphorylation	SPAYSLGSLTGASPR CCCCCHHHCCCCCCC	28.22	20469934
550	Phosphorylation	AYSLGSLTGASPRQS CCCHHHCCCCCCCCC	32.19	26824392
553	Phosphorylation	LGSLTGASPRQSPRA HHHCCCCCCCCCHHH	23.20	27087446
557	Phosphorylation	TGASPRQSPRAQRKL CCCCCCCCHHHHHHC	20.03	27087446
565	Phosphorylation	PRAQRKLSSGDLRVP HHHHHHCCCCCCCCC	35.00	26824392
566	Phosphorylation	RAQRKLSSGDLRVPI HHHHHCCCCCCCCCC	46.92	26824392
580	Phosphorylation	IPRERKNSITEISDN CCHHHCCCCEECCCC	33.64	25521595
582	Phosphorylation	RERKNSITEISDNED HHHCCCCEECCCCHH	27.38	27742792
585	Phosphorylation	KNSITEISDNEDELL CCCCEECCCCHHHHH	28.31	25521595
594	Phosphorylation	NEDELLEYHRRQRQE CHHHHHHHHHHHHHH	10.70	25168779
618	Phosphorylation	LERQRLETILNLCAE HHHHHHHHHHHHHHH	35.04	-
640	Phosphorylation	PETGELPSIGEATAA CCCCCCCCHHHHHHH	56.71	26824392
656	Phosphorylation	ALAGRRPSRGLAGAI HHCCCCCCCCCCCEE	36.85	27074791
683	Phosphorylation	ASQRLWESMERSDEE HHHHHHHHHHHCCHH	17.86	28418008
687	Phosphorylation	LWESMERSDEENLKE HHHHHHHCCHHHHHH	35.75	27087446
697	Phosphorylation	ENLKEECSSTESTQQ HHHHHHHCCCHHHHH	43.50	25521595
698	Phosphorylation	NLKEECSSTESTQQE HHHHHHCCCHHHHHH	48.10	25521595
699	Phosphorylation	LKEECSSTESTQQEH HHHHHCCCHHHHHHH	20.05	25521595
701	Phosphorylation	EECSSTESTQQEHED HHHCCCHHHHHHHCC	31.44	25521595
702	Phosphorylation	ECSSTESTQQEHEDA HHCCCHHHHHHHCCC	28.21	27087446
770	Phosphorylation	EREAERASLQKEQRA HHHHHHHHHHHHHHH	37.24	29514104
838	Phosphorylation	AGQGLLRSKAELLRS HHHHHHHHHHHHHHH	35.87	28059163
845	Phosphorylation	SKAELLRSVSKRKER HHHHHHHHHHHHHHH	30.61	23737553
847	Phosphorylation	AELLRSVSKRKERLA HHHHHHHHHHHHHHH	28.17	23737553
899	Phosphorylation	LNVLERRYHSLTGGR HHHHHHHHHHHHCCC	11.28	29514104
901	Phosphorylation	VLERRYHSLTGGRPF HHHHHHHHHHCCCCC	20.77	-
950	Phosphorylation	LAAASPRSSPPPLPA CHHCCCCCCCCCCCC	51.05	23527152
951	Phosphorylation	AAASPRSSPPPLPAK HHCCCCCCCCCCCCH	42.58	25521595
969	Ubiquitination	QLQVYRSKMDSDAAS HHHHHHHHCCCCCCC	37.41	-
972	Phosphorylation	VYRSKMDSDAASPLP HHHHHCCCCCCCCCC	26.17	23737553
976	Phosphorylation	KMDSDAASPLPRTRS HCCCCCCCCCCCCCC	28.79	24899341
981	Phosphorylation	AASPLPRTRSGPLPS CCCCCCCCCCCCCCC	27.52	26643407
983	Phosphorylation	SPLPRTRSGPLPSSS CCCCCCCCCCCCCCC	44.12	25619855
988	Phosphorylation	TRSGPLPSSSGSSSS CCCCCCCCCCCCCCC	44.83	25619855
989	Phosphorylation	RSGPLPSSSGSSSSS CCCCCCCCCCCCCCC	36.46	25619855
990	Phosphorylation	SGPLPSSSGSSSSSS CCCCCCCCCCCCCCC	47.21	25619855
994	Phosphorylation	PSSSGSSSSSSQLSV CCCCCCCCCCCCEEE	35.62	25619855
995	Phosphorylation	SSSGSSSSSSQLSVA CCCCCCCCCCCEEEE	35.64	25619855
996	Phosphorylation	SSGSSSSSSQLSVAT CCCCCCCCCCEEEEE	24.85	25619855
997	Phosphorylation	SGSSSSSSQLSVATL CCCCCCCCCEEEEEC	36.77	25619855
1003	Phosphorylation	SSQLSVATLGRSPSP CCCEEEEECCCCCCH	27.82	25619855
1007	Phosphorylation	SVATLGRSPSPKSAL EEEECCCCCCHHHHH	28.12	29899451
1009	Phosphorylation	ATLGRSPSPKSALLA EECCCCCCHHHHHHH	46.32	21659605
1012	Phosphorylation	GRSPSPKSALLAQNG CCCCCHHHHHHHCCC	27.77	23984901
1020	Phosphorylation	ALLAQNGTSSLPRNL HHHHCCCCCCCCHHH	23.77	26643407
1021	Phosphorylation	LLAQNGTSSLPRNLA HHHCCCCCCCCHHHH	31.13	27087446
1022	Phosphorylation	LAQNGTSSLPRNLAA HHCCCCCCCCHHHHH	42.08	27087446
1030	Phosphorylation	LPRNLAATLQDIETK CCHHHHHHHHHHHHH	21.24	23984901
1203	Phosphorylation	ERRLQSESARRQQLV HHHHHCHHHHHHHHH	32.11	29514104
1222	Phosphorylation	KLREKQFSQARPLTR HHCHHHHHCCCCCHH	22.04	29514104
1228	Phosphorylation	FSQARPLTRYLPNRK HHCCCCCHHCCCCCH	21.68	26824392
1230	Phosphorylation	QARPLTRYLPNRKED CCCCCHHCCCCCHHH	22.67	29514104
1242	Phosphorylation	KEDFDLKTHIESSGH HHHCCCCHHHHCCCC	35.07	29899451
1246	Phosphorylation	DLKTHIESSGHGVDT CCCHHHHCCCCCHHH	40.80	29899451
1247	Phosphorylation	LKTHIESSGHGVDTC CCHHHHCCCCCHHHH	23.24	21183079
1260	Phosphorylation	TCLHVVLSSKVCRGY HHHHHHHCCCCHHEE	19.26	21183079

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
445	S	Phosphorylation	Kinase	MAPK1	P63085	GPS
463	S	Phosphorylation	Kinase	MAPK1	P63085	GPS
1007	S	Phosphorylation	Kinase	MTOR	Q9JLN9	PSP
1009	S	Phosphorylation	Kinase	MTOR	Q9JLN9	PSP

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of PHLB1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of PHLB1_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of PHLB1_MOUSE !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of PHLB1_MOUSE

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Solid tumor proteome and phosphoproteome analysis by high resolutionmass spectrometry."; Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J.,Faessler R., Mann M.; J. Proteome Res. 7:5314-5326(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-565, AND MASSSPECTROMETRY.	19367708 [Abstract]
"Large-scale phosphorylation analysis of mouse liver."; Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-520, AND MASSSPECTROMETRY.	17242355 [Abstract]