ENTP2_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ENTP2_MOUSE
• UniProt AC: O55026
• Protein Name: Ectonucleoside triphosphate diphosphohydrolase 2
• Gene Name: Entpd2
• Organism: Mus musculus (Mouse).
• Sequence Length: 495
• Subcellular Localization: Isoform Long: Cell membrane; Multi-pass membrane protein.
• Protein Description: In the nervous system, could hydrolyze ATP and other nucleotides to regulate purinergic neurotransmission. Hydrolyzes ADP only to a marginal extent (By similarity)..
• Protein Sequence: MAGKLVSLVPPLLLAAVGLAGLLLLCVPTQDVREPPALKYGIVLDAGSSHTSMFVYKWPADKENDTGIVGQHSSCDVRGGGISSYANDPSRAGQSLVECLEQALRDVPKDRYASTPLYLGATAGMRLLNLTSPEATAKVLEAVTQTLTRYPFDFRGARILSGQDEGVFGWVTANYLLENFIKYGWVGRWIRPRKGTLGAMDLGGASTQITFETTSPSEDPDNEVHLRLYGQHYRVYTHSFLCYGRDQVLQRLLASALQIHRFHPCWPKGYSTQVLLREVYQSPCTMGQRPQTFNSSATVSLSGTSNAALCRDLVSGLFNISSCPFSQCSFNGVFQPPVAGNFIAFSAFYYTVDFLKTVMGLPVGTLKQLEDATETTCNQTWAELQARVPGQQTRLPDYCAVAMFIHQLLSRGYRFDERSFRGVVFEKKAADTAVGWALGYMLNLTNLIPADLPGLRKGTHFSSWVALLLLFTVLILAALVLLLRQVRSAKSPGAL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
64	N-linked_Glycosylation	KWPADKENDTGIVGQ EEECCCCCCCCCCCC	58.86	-
129	N-linked_Glycosylation	TAGMRLLNLTSPEAT CHHCHHHCCCCHHHH	45.95	19349973
294	N-linked_Glycosylation	GQRPQTFNSSATVSL CCCCCCCCCCCEEEE	38.14	-
319	N-linked_Glycosylation	DLVSGLFNISSCPFS HHHHHHCCCCCCCCC	37.97	-
378	N-linked_Glycosylation	DATETTCNQTWAELQ HHCHHHHHHHHHHHH	39.98	-
443	N-linked_Glycosylation	WALGYMLNLTNLIPA HHHHHHHHHHHCCCC	28.43	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ENTP2_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ENTP2_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ENTP2_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of ENTP2_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

N-linked Glycosylation

"Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins.";
Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M.,Schiess R., Aebersold R., Watts J.D.;
Nat. Biotechnol. 27:378-386(2009).
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-129, AND MASSSPECTROMETRY.
PubMed: 19349973