CARL1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CARL1_MOUSE
• UniProt AC: Q6EDY6
• Protein Name: F-actin-uncapping protein LRRC16A {ECO:0000250|UniProtKB:Q5VZK9}
• Gene Name: Carmil1 {ECO:0000250|UniProtKB:Q5VZK9}
• Organism: Mus musculus (Mouse).
• Sequence Length: 1374
• Subcellular Localization: Cytoplasm . Cytoplasm, cytoskeleton . Cell membrane . Cell projection, lamellipodium . Found on macropinosomes (By similarity). Colocalized with heterodimeric capping protein (CP) and F-actin in lamellipodia but not with F-actin in stress fibers (Pub
• Protein Description: Cell membrane-cytoskeleton-associated protein that plays a role in the regulation of actin polymerization at the barbed end of actin filaments. Prevents F-actin heterodimeric capping protein (CP) activity at the leading edges of migrating cells, and hence generates uncapped barbed ends and enhances actin polymerization, however, seems unable to nucleate filaments. [PubMed: 16054028 Plays a role in lamellipodial protrusion formations and cell migration]
• Protein Sequence: MTDESSDVPRELMESIKDVIGRKIKISVKKKVKLEVKGDRVENKVLVLTSCRAFLLSARIPSKLELTFSYLEIHGVICHKPAQMVVETEKCNMSMKMVSPEDVSEVLAHIGTCLRRIFPGLSPLRIMKKVSMEPSERLASLQALWDSQTLAEPGPCGGFSQMYACVCDWLGFSYKEEVQWDVDTIYLTQDTRELNLQDFSHLEHRDLIPIIAALEYNQWFTKLSSKDLKLSTDVCEQILRVVSRSNRLEELVLENAGLRIDFAQKLAGALAHNPNSGLHTINLAGNSLEDRGVSSLSIQFAKLPKGLKHLNLSKTSLSPKGVNSLCQSLSANPLTASTLTHLDLSGNALRGDDLSHMYNFLAQPNTIVHLDLSNTECSLEMVCSALLRGCLQCLAVLNLSRSVFSHRKGKEVPPSFKQFFSSSLALIQINLSGTKLSPEPLKALLLGLACNHSLKGVSLDLSNCELGHCLRSGGAQVLEGCIAEIHNITSLDISDNGLESDLSTLIVWLSKNRSIQHLALGKNFNNMKSKNLTPVLDNLVQMIQDEDSPLQSLSLADSKLKAEVTIIINALGSNTSLTKVDISGNGMGDMGAKMLAKALQINTKLRTVIWDKNNITAQGFQDIAVAMEKNYTLRFMPIPMYDAAQALKTNPEKTEEALQKIENYLLRNHETRKYLQEQAYRLQQGIVTSTTQQMIDRICVKVQDHLNSLRACGGDAIQEDLKAAERLMRDAKNSKTLLPNLYHVGGASWAGASGLSSSPIQETLESMAGEVTRVVDEQLKDLLESMVDAAETLCPNVMRKAHIRQDLIHASTEKISIPRTFVKNVLLEQSGIDILNKISEVKLTVASFLSDRIVDEILDSLSSSHRKLANHFSRLNKSLPQREDLEVELVEEKPVKRAILTVEDLTEVERLEDLDTCMMTPKSKRKSIHSRMLRPVSRAFEMEFDLDKALEEVPIHIEDPPFPSVRQEKRSSGLISELPSEEGRRLEHFTKLRPKRNKKQQPTQAAVCTISILPQDGEQNGLMGRVDEGVDEFFTKKVTKMDCKRSSSRSSDAHELGEGDEKKKRDSRRSGFLNLIKSRSRSERPPTVLMTEELSSPKGAMRSPPVDTTRKEIKAAEHNGAPDRTEEIKTPEPLEEGPAEEAGRAERSDSRGSPQGGRRYVQVMGSGLLAEMKAKQERRAACAQKKLGNDVISQDPSSPVSCNTERLEGGATVPKLQPGLPEARFGSGTPEKNAKAEPRVDGGCRSRSSSSMPTSPKPLLQSPKPSPSARPSIPQKPRTASRPEDTPDSPSGPSSPKVALLPPILKKVSSDKERDGQNSSQSSPRSFSQEASRRSWGPAQEYQEQKQRSSGKDGHQGSKCSDSGEEAEKEFIFV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MTDESSDV -------CCCCCCHH		-
2	Phosphorylation	------MTDESSDVP ------CCCCCCHHC		28576409
6	Phosphorylation	--MTDESSDVPRELM --CCCCCCHHCHHHH		29895711
57	Phosphorylation	SCRAFLLSARIPSKL HHHHHHHHCCCCCCC		21183079
62	Phosphorylation	LLSARIPSKLELTFS HHHCCCCCCCEEEEE		21183079
122	Phosphorylation	RRIFPGLSPLRIMKK HHHCCCCCHHHHHHH		26824392
308	Ubiquitination	AKLPKGLKHLNLSKT CCCCCCCCCCCCCCC		-
324	Phosphorylation	LSPKGVNSLCQSLSA CCHHHHHHHHHHHCC		25777480
328	Phosphorylation	GVNSLCQSLSANPLT HHHHHHHHHCCCCCC		25777480
330	Phosphorylation	NSLCQSLSANPLTAS HHHHHHHCCCCCCHH		25777480
335	Phosphorylation	SLSANPLTASTLTHL HHCCCCCCHHHCCEE		25777480
337	Phosphorylation	SANPLTASTLTHLDL CCCCCCHHHCCEEEC		25777480
338	Phosphorylation	ANPLTASTLTHLDLS CCCCCHHHCCEEECC		25777480
340	Phosphorylation	PLTASTLTHLDLSGN CCCHHHCCEEECCCC		25777480
345	Phosphorylation	TLTHLDLSGNALRGD HCCEEECCCCCCCCC		25777480
578	Phosphorylation	LGSNTSLTKVDISGN CCCCCCCEEEECCCC		22807455
604	Ubiquitination	KALQINTKLRTVIWD HHHHHCCCCCEEEEC		-
736	Phosphorylation	RDAKNSKTLLPNLYH HHHHHCCCCCCCCEE		26239621
757	Phosphorylation	AGASGLSSSPIQETL CCCCCCCCCCHHHHH		26239621
758	Phosphorylation	GASGLSSSPIQETLE CCCCCCCCCHHHHHH		26239621
766	Phosphorylation	PIQETLESMAGEVTR CHHHHHHHHCHHHHH		26239621
823	Ubiquitination	SIPRTFVKNVLLEQS CCCHHHHHHHHHHHH		-
830	Phosphorylation	KNVLLEQSGIDILNK HHHHHHHHCHHHHHH		25521595
862	Phosphorylation	DEILDSLSSSHRKLA HHHHHHCCHHHHHHH		21183079
873	Phosphorylation	RKLANHFSRLNKSLP HHHHHHHHHHHHCCC		21183079
878	Phosphorylation	HFSRLNKSLPQREDL HHHHHHHCCCCCCCC		28973931
901	Phosphorylation	PVKRAILTVEDLTEV CCCEEEEEHHHCCHH		28973931
906	Phosphorylation	ILTVEDLTEVERLED EEEHHHCCHHHCHHH		23140645
916	Phosphorylation	ERLEDLDTCMMTPKS HCHHHCCCCCCCCHH		25619855
920	Phosphorylation	DLDTCMMTPKSKRKS HCCCCCCCCHHHHHC		25521595
937	Phosphorylation	SRMLRPVSRAFEMEF HHCHHHHHHHHHEEE		26643407
964	Phosphorylation	IEDPPFPSVRQEKRS CCCCCCCCCCHHHHH		-
971	Phosphorylation	SVRQEKRSSGLISEL CCCHHHHHCCCCCCC		27087446
972	Phosphorylation	VRQEKRSSGLISELP CCHHHHHCCCCCCCC		25521595
976	Phosphorylation	KRSSGLISELPSEEG HHHCCCCCCCCCCCC		25619855
980	Phosphorylation	GLISELPSEEGRRLE CCCCCCCCCCCCCHH		25619855
1046	Phosphorylation	TKMDCKRSSSRSSDA CHHHCCCCCCCCCCH		20469934
1047	Phosphorylation	KMDCKRSSSRSSDAH HHHCCCCCCCCCCHH		27841257
1048	Phosphorylation	MDCKRSSSRSSDAHE HHCCCCCCCCCCHHH		29550500
1050	Phosphorylation	CKRSSSRSSDAHELG CCCCCCCCCCHHHCC		27087446
1051	Phosphorylation	KRSSSRSSDAHELGE CCCCCCCCCHHHCCC		29514104
1067	Phosphorylation	DEKKKRDSRRSGFLN CCHHHHHHHHHHHHH		-
1070	Phosphorylation	KKRDSRRSGFLNLIK HHHHHHHHHHHHHHH		26239621
1087	Phosphorylation	SRSERPPTVLMTEEL CCCCCCCEEEEECCC		29514104
1095	Phosphorylation	VLMTEELSSPKGAMR EEEECCCCCCCCCCC		26643407
1096	Phosphorylation	LMTEELSSPKGAMRS EEECCCCCCCCCCCC		26239621
1103	Phosphorylation	SPKGAMRSPPVDTTR CCCCCCCCCCCCCCH		29895711
1130	Phosphorylation	DRTEEIKTPEPLEEG CCCCCCCCCCCCCCC		21149613
1148	Phosphorylation	EAGRAERSDSRGSPQ HHCCCCCCCCCCCCC		27681418
1150	Phosphorylation	GRAERSDSRGSPQGG CCCCCCCCCCCCCCC		23140645
1153	Phosphorylation	ERSDSRGSPQGGRRY CCCCCCCCCCCCHHH		25521595
1160	Phosphorylation	SPQGGRRYVQVMGSG CCCCCHHHEEEECCH		29514104
1166	Phosphorylation	RYVQVMGSGLLAEMK HHEEEECCHHHHHHH		29514104
1193	Phosphorylation	KLGNDVISQDPSSPV HHCCCCCCCCCCCCC		26643407
1197	Phosphorylation	DVISQDPSSPVSCNT CCCCCCCCCCCCCCC		25619855
1198	Phosphorylation	VISQDPSSPVSCNTE CCCCCCCCCCCCCCC		25619855
1201	Phosphorylation	QDPSSPVSCNTERLE CCCCCCCCCCCCCCC		25619855
1204	Phosphorylation	SSPVSCNTERLEGGA CCCCCCCCCCCCCCC		25619855
1227	Phosphorylation	LPEARFGSGTPEKNA CCHHHCCCCCCCCCC		27149854
1229	Phosphorylation	EARFGSGTPEKNAKA HHHCCCCCCCCCCCC		26643407
1248	Phosphorylation	DGGCRSRSSSSMPTS CCCCCCCCCCCCCCC		23684622
1249	Phosphorylation	GGCRSRSSSSMPTSP CCCCCCCCCCCCCCC		23684622
1250	Phosphorylation	GCRSRSSSSMPTSPK CCCCCCCCCCCCCCC		23684622
1251	Phosphorylation	CRSRSSSSMPTSPKP CCCCCCCCCCCCCCC		26643407
1254	Phosphorylation	RSSSSMPTSPKPLLQ CCCCCCCCCCCCCCC		26643407
1255	Phosphorylation	SSSSMPTSPKPLLQS CCCCCCCCCCCCCCC		26643407
1262	Phosphorylation	SPKPLLQSPKPSPSA CCCCCCCCCCCCCCC		26824392
1266	Phosphorylation	LLQSPKPSPSARPSI CCCCCCCCCCCCCCC		26643407
1268	Phosphorylation	QSPKPSPSARPSIPQ CCCCCCCCCCCCCCC		26643407
1272	Phosphorylation	PSPSARPSIPQKPRT CCCCCCCCCCCCCCC		26643407
1279	Phosphorylation	SIPQKPRTASRPEDT CCCCCCCCCCCCCCC		25619855
1281	Phosphorylation	PQKPRTASRPEDTPD CCCCCCCCCCCCCCC		25619855
1286	Phosphorylation	TASRPEDTPDSPSGP CCCCCCCCCCCCCCC		25619855
1289	Phosphorylation	RPEDTPDSPSGPSSP CCCCCCCCCCCCCCC		25521595
1291	Phosphorylation	EDTPDSPSGPSSPKV CCCCCCCCCCCCCCC		27087446
1294	Phosphorylation	PDSPSGPSSPKVALL CCCCCCCCCCCCCCC		25521595
1295	Phosphorylation	DSPSGPSSPKVALLP CCCCCCCCCCCCCCC		25521595
1319	Phosphorylation	KERDGQNSSQSSPRS CCCCCCCCCCCCCCC		-
1320	Phosphorylation	ERDGQNSSQSSPRSF CCCCCCCCCCCCCCC		19367708
1322	Phosphorylation	DGQNSSQSSPRSFSQ CCCCCCCCCCCCCCH		29899451
1323	Phosphorylation	GQNSSQSSPRSFSQE CCCCCCCCCCCCCHH		26824392
1326	Phosphorylation	SSQSSPRSFSQEASR CCCCCCCCCCHHHHH		26643407
1328	Phosphorylation	QSSPRSFSQEASRRS CCCCCCCCHHHHHHC		26643407
1332	Phosphorylation	RSFSQEASRRSWGPA CCCCHHHHHHCCCHH		26643407
1335	Phosphorylation	SQEASRRSWGPAQEY CHHHHHHCCCHHHHH		25521595
1342	Phosphorylation	SWGPAQEYQEQKQRS CCCHHHHHHHHHHHH		25619855
1358	Phosphorylation	GKDGHQGSKCSDSGE CCCCCCCCCCCCCCC		21183079
1361	Phosphorylation	GHQGSKCSDSGEEAE CCCCCCCCCCCCHHH		26824392
1363	Phosphorylation	QGSKCSDSGEEAEKE CCCCCCCCCCHHHHH		16141072

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CARL1_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CARL1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CARL1_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of CARL1_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.