UN13B_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: UN13B_MOUSE
• UniProt AC: Q9Z1N9
• Protein Name: Protein unc-13 homolog B
• Gene Name: Unc13b
• Organism: Mus musculus (Mouse).
• Sequence Length: 1602
• Subcellular Localization: Cytoplasm. Membrane; Peripheral membrane protein. Golgi apparatus. Cell junction, synapse. Localized to synapses (By similarity). Translocates to the Golgi in response to phorbol ester binding..
• Protein Description: Plays a role in vesicle maturation during exocytosis as a target of the diacylglycerol second messenger pathway. Is involved in neurotransmitter release by acting in synaptic vesicle priming prior to vesicle fusion and participates in the activity-depending refilling of readily releasable vesicle pool (RRP) (By similarity). Essential for synaptic vesicle maturation in a subset of excitatory/glutamatergic but not inhibitory/GABA-mediated synapses..
• Protein Sequence: MSLLCVRVKRAKFQGSPDKFNTYVTLKVQNVKSTTVAVRGDQPSWEQDFMFEISRLDLGLSVEVWNKGLIWDTMVGTVWIALKTIRQSDEEGPGEWSTLEAETLMKDDEICGTKNPTPHKILLDTRFELPFDIPEEEARYWTYKLEQINALADDNEYSSQEESQRKPLPTAAAQCCHWTYLGWGEHQTFEDPDSAVDDRDSDYRSETSNSAPPPYHTTTQPNASVHQFPVPVRLPQQLFLQGSSHDSCNDSMQSYDLDYPERRALSPTSSSRYGSSCNVSQGSSLLSELDQYHEQDDDGRERDSIHSSHSYGSLSKDGQAGLGEQEKALEVTCESEKEKTGESKEMRDDATIHPPSDLVLHKDHVLGPQESLPEETASSPFTQARAHWFRAVTKVRLQLQEISDDGDPSLPQWLPEGPAGGLYGIDSMPDLRRKKPLPLVSDLSLVQSRKAGITSAMATRTSLKDEELKSHVYKKTLQALIYPISCTTPHNFEVWSATTPTYCYECEGLLWGLARQGMRCSECGVKCHEKCQDLLNADCLQRAAEKSSKHGAEDRTQNIIMAMKDRMKIRERNKPEIFEVIRDVFTVSKVAHVQQMKTVKQSVLDGTSKWSAKITITVVCAQGLQAKDKTGSSDPYVTVQVGKTKKRTKTIFGNLNPVWEEKFHFECHNSSDRIKVRVWDEDDDIKSRVKQRLKRESDDFLGQTIIEVRTLSGEMDVWYNLEKRTDKSAVSGAIRLQISVEIKGEEKVAPYHVQYTCLHENLFHYLTDIQGSGGVWIPEARGDDAWKVYFDETAQEIVDEFAMRYGIESIYQAMTHFACLSSKYMCPGVPAVMSTLLANINAYYAHTTASTNVSASDRFAASNFGKERFVKLLDQLHNSLRIDLSTYRNNFPAGSPERLQDLKSTVDLLTSITFFRMKVQELQSPPRASQVVKDCVKACLNSTYEYIFNNCHDLYSHQYQLQEQPLEEPGPSIRNLDFWPKLITLIVSIIEEDKNSYTPVLSQFPQELNVGKVSAEVMWHLFAQDMKYALEEHEKDRLCKSADYMNLHFKVKWLHNEYVRDLPALQGQVPEYPAWFEQFVLQWLDENEDVSLEFLRGALERDKKDGFQQTSEHALFSCSVVDVFTQLNQSFEIIRKLECPDPNILAHYMRRFAKTIGKVLMQYADILSKNFPAYCTKERLPCILMNNMQQLRVQLEKMFEAMGGKELDSEAADSLKELQVKLNTVLDELSMVFGNSFQVRIDECVRQMADILGQVRGTGNASPNARASVAQDADSVLRPLMDFLDGNLTLFATVCEKTVLKRVLKELWRVVMNTMERVIVLPPLTDQTGTQLILTAAKELSQLSKLKDHMVREETRNLTPKQCAVLDLALDTIKQYFHAGGNGLKKTFLEKSPDLQSLRYALSLYTQTTDTLIKTFVRSQTAQGAGVDDPVGEVSIQVDLFTHPGTGEHKVTVKVVAANDLKWQTAGMFRPFVEVTMVGPHQSDKKRKFTTKSKSNNWTPKYNETFHFLLGNEEGPEAYELQICVKDYCFAREDRVIGLAVMPLRDVAAKGSCACWCPLGRKIHMDETGMTILRILSQRSNDEVAREFVKLKSESRSTEEGS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
16	Phosphorylation	KRAKFQGSPDKFNTY EEHHCCCCCCCCCEE	21.10	-
259	Phosphorylation	MQSYDLDYPERRALS HHHCCCCCHHHHCCC	17.81	-
266	Phosphorylation	YPERRALSPTSSSRY CHHHHCCCCCCCCCC	25.75	27841257
307	Phosphorylation	RERDSIHSSHSYGSL CCCCCCCCCCCCCCC	28.24	20469934
308	Phosphorylation	ERDSIHSSHSYGSLS CCCCCCCCCCCCCCC	11.42	20469934
310	Phosphorylation	DSIHSSHSYGSLSKD CCCCCCCCCCCCCCC	32.89	27841257
371	Phosphorylation	HVLGPQESLPEETAS CCCCCHHCCCCCCCC	43.93	29899451
376	Phosphorylation	QESLPEETASSPFTQ HHCCCCCCCCCHHHH	30.12	29472430
378	Phosphorylation	SLPEETASSPFTQAR CCCCCCCCCHHHHHH	46.06	26643407
379	Phosphorylation	LPEETASSPFTQARA CCCCCCCCHHHHHHH	22.90	26643407
382	Phosphorylation	ETASSPFTQARAHWF CCCCCHHHHHHHHHH	25.38	29472430
441	Phosphorylation	KKPLPLVSDLSLVQS CCCCCCCCCHHHHHH	40.28	-
444	Phosphorylation	LPLVSDLSLVQSRKA CCCCCCHHHHHHHHC	31.33	-
448	Phosphorylation	SDLSLVQSRKAGITS CCHHHHHHHHCCCCH	28.41	-
454	Phosphorylation	QSRKAGITSAMATRT HHHHCCCCHHHCCCC	14.98	28576409
459	Phosphorylation	GITSAMATRTSLKDE CCCHHHCCCCCCCHH	22.76	28576409
1209	Phosphorylation	MGGKELDSEAADSLK CCCCCCCHHHHHHHH	41.58	25159016
1256	Methylation	ADILGQVRGTGNASP HHHHHHHCCCCCCCC	29.12	16188527
1262	Phosphorylation	VRGTGNASPNARASV HCCCCCCCCCCCHHH	23.76	27087446
1446	Phosphorylation	DLFTHPGTGEHKVTV EEEECCCCCCCEEEE	43.79	-
1494	Acetylation	RKFTTKSKSNNWTPK CCEECCCCCCCCCCC	59.77	7712135

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of UN13B_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of UN13B_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of UN13B_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of UN13B_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.