HECAM_MOUSE - dbPTM
HECAM_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID HECAM_MOUSE
UniProt AC Q640R3
Protein Name Hepatocyte cell adhesion molecule
Gene Name Hepacam {ECO:0000312|MGI:MGI:1920177}
Organism Mus musculus (Mouse).
Sequence Length 418
Subcellular Localization Cytoplasm. Membrane
Single-pass type I membrane protein
Cytoplasmic side . Colocalizes with CDH1.
Protein Description Involved in regulating cell motility and cell-matrix interactions. May inhibit cell growth through suppression of cell proliferation (By similarity)..
Protein Sequence MKRERGALSRASRALRLSPFVYLLLIQPVPLEGVNITSPVRLIHGTVGKSALLSVQYSSTSSDKPVVKWQLKRDKPVTVVQSIGTEVIGTLRPDYRDRIRLFENGSLLLSDLQLADEGTYEVEISITDDTFTGEKTINLTVDVPISRPQVLVASTTVLELSEAFTLNCSHENGTKPSYTWLKDGKPLLNDSRMLLSPDQKVLTITRVLMEDDDLYSCVVENPISQVRSLPVKITVYRRSSLYIILSTGGIFLLVTLVTVCACWKPSKKSRKKRKLEKQNSLEYMDQNDDRLKSEADTLPRSGEQERKNPMALYILKDKDSSEPDENPATEPRSTTEPGPPGYSVSPPVPGRSPGLPIRSARRYPRSPARSPATGRTHTSPPRAPSSPGRSRSSSRSLRTAGVQRIREQDESGQVEISA
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
35N-linked_GlycosylationPVPLEGVNITSPVRL
CCCCCCCCCCCCEEE		42.55-
138N-linked_GlycosylationFTGEKTINLTVDVPI
CCCEEEEEEEEECCC		34.59-
167N-linked_GlycosylationLSEAFTLNCSHENGT
HHHEEECCCCCCCCC		23.37-
189N-linked_GlycosylationKDGKPLLNDSRMLLS
ECCCCCCCCCCCCCC		53.55-
205PhosphorylationDQKVLTITRVLMEDD
CCEEEEEEEEEECCC		14.9728285833
216PhosphorylationMEDDDLYSCVVENPI
ECCCCHHHCEEECCH		14.0328285833
224PhosphorylationCVVENPISQVRSLPV
CEEECCHHHHHCCCE		24.7128285833
280PhosphorylationRKLEKQNSLEYMDQN
HHHHHHCHHHHHHCC		21.7825521595
283PhosphorylationEKQNSLEYMDQNDDR
HHHCHHHHHHCCCHH		15.9825521595
292UbiquitinationDQNDDRLKSEADTLP
HCCCHHHHHHHHHCC		47.33-
293PhosphorylationQNDDRLKSEADTLPR
CCCHHHHHHHHHCCC		42.4823527152
297PhosphorylationRLKSEADTLPRSGEQ
HHHHHHHHCCCCCHH		45.7925521595
301PhosphorylationEADTLPRSGEQERKN
HHHHCCCCCHHHHCC		44.7525521595
307UbiquitinationRSGEQERKNPMALYI
CCCHHHHCCCEEEEE		65.73-
313PhosphorylationRKNPMALYILKDKDS
HCCCEEEEEECCCCC		8.4829899451
316UbiquitinationPMALYILKDKDSSEP
CEEEEEECCCCCCCC		53.85-
318UbiquitinationALYILKDKDSSEPDE
EEEEECCCCCCCCCC		58.90-
320PhosphorylationYILKDKDSSEPDENP
EEECCCCCCCCCCCC		42.2025521595
321PhosphorylationILKDKDSSEPDENPA
EECCCCCCCCCCCCC		64.3825521595
329PhosphorylationEPDENPATEPRSTTE
CCCCCCCCCCCCCCC		48.0229899451
333PhosphorylationNPATEPRSTTEPGPP
CCCCCCCCCCCCCCC		50.8523527152
334PhosphorylationPATEPRSTTEPGPPG
CCCCCCCCCCCCCCC		36.1429899451
342PhosphorylationTEPGPPGYSVSPPVP
CCCCCCCCCCCCCCC		16.2129899451
343PhosphorylationEPGPPGYSVSPPVPG
CCCCCCCCCCCCCCC		23.2529899451
345PhosphorylationGPPGYSVSPPVPGRS
CCCCCCCCCCCCCCC		19.9724925903
352PhosphorylationSPPVPGRSPGLPIRS
CCCCCCCCCCCCCHH		29.2725521595
359PhosphorylationSPGLPIRSARRYPRS
CCCCCCHHCCCCCCC		27.1829899451
366PhosphorylationSARRYPRSPARSPAT
HCCCCCCCCCCCCCC		20.5729899451
370PhosphorylationYPRSPARSPATGRTH
CCCCCCCCCCCCCCC		22.4625521595
376PhosphorylationRSPATGRTHTSPPRA
CCCCCCCCCCCCCCC		30.7425521595
378PhosphorylationPATGRTHTSPPRAPS
CCCCCCCCCCCCCCC		42.1725521595
379PhosphorylationATGRTHTSPPRAPSS
CCCCCCCCCCCCCCC		25.8825521595
385PhosphorylationTSPPRAPSSPGRSRS
CCCCCCCCCCCCCCC		48.4525521595
386PhosphorylationSPPRAPSSPGRSRSS
CCCCCCCCCCCCCCC		30.2525521595
390PhosphorylationAPSSPGRSRSSSRSL
CCCCCCCCCCCCHHH		42.2929899451
417PhosphorylationESGQVEISA------
CCCCEEECC------		17.8922807455
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of HECAM_MOUSE !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of HECAM_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of HECAM_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of HECAM_MOUSE !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of HECAM_MOUSE

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Qualitative and quantitative analyses of protein phosphorylation innaive and stimulated mouse synaptosomal preparations.";
Munton R.P., Tweedie-Cullen R., Livingstone-Zatchej M., Weinandy F.,Waidelich M., Longo D., Gehrig P., Potthast F., Rutishauser D.,Gerrits B., Panse C., Schlapbach R., Mansuy I.M.;
Mol. Cell. Proteomics 6:283-293(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-280; SER-320 ANDSER-352, AND MASS SPECTROMETRY.

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