TBCE_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TBCE_MOUSE
• UniProt AC: Q8CIV8
• Protein Name: Tubulin-specific chaperone E
• Gene Name: Tbce
• Organism: Mus musculus (Mouse).
• Sequence Length: 524
• Subcellular Localization: Cytoplasm. Cytoplasm, cytoskeleton.
• Protein Description: Tubulin-folding protein; involved in the second step of the tubulin folding pathway and in the regulation of tubulin heterodimer dissociation. [PubMed: 12389029]
• Protein Sequence: MSDILPLDVIGRRVEVNGEYATVRFCGAVPPVAGLWLGVEWDNPERGKHDGSHEGTMYFKCRHPTGGSFVRPSKVNFGDDFLTALKKRYVLEDGPDDDENSCSLKVGSKQVQTIGFEHITKKQSQLRALQDISLWNCAVSHAGEQGRIAEACPNIRVVNLSKNLLSTWDEVVLIAEQLKDLEALDLSENKLQFPSDSPTLTRTFSTLKTLVLNKTGITWTEVLHCAPSWPVLEELYLKSNNISISERPVNVLQKMRLLDLSSNPSIDESQLSLIADLPRLEHLVLSDIGLSSIHFPDAEIGCKTSMFPALKYLIVNDNQISEWSFINELDKLQSLQALSCTRNPLSKADKAEEIIIAKIAQLRTLNRCQILPEERRGAELDYRKAFGNEWRKAGGHPDPDKNRPNAAFLSAHPRYQLLCCKYGAPEDEELKTQQPFMLKKQLLTLKIKCSNQPERQILEKQLPDSMTVQKVKGLLSRLLKVPVSELLLSYESSKMPGREIELENDLQPLQFYSVENGDCLLVRW

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MSDILPLDV ------CCCCCCCEE	33.10	-
2	Phosphorylation	------MSDILPLDV ------CCCCCCCEE	33.10	28066266
243	Phosphorylation	YLKSNNISISERPVN HHHHCCCCCCCCCCH	23.37	23737553
245	Phosphorylation	KSNNISISERPVNVL HHCCCCCCCCCCHHH	22.29	23737553
261	Phosphorylation	KMRLLDLSSNPSIDE HCHHHCCCCCCCCCH	27.95	26643407
265	Phosphorylation	LDLSSNPSIDESQLS HCCCCCCCCCHHHHH	47.09	26643407
460	Acetylation	PERQILEKQLPDSMT HHHHHHHHHCCCCHH	54.40	-
476	Phosphorylation	QKVKGLLSRLLKVPV HHHHHHHHHHHCCCH	26.40	28978645
492	Phosphorylation	ELLLSYESSKMPGRE HHHHHHHHCCCCCCE	27.33	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TBCE_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TBCE_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TBCE_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of TBCE_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.