NDRG3_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NDRG3_MOUSE
• UniProt AC: Q9QYF9
• Protein Name: Protein NDRG3
• Gene Name: Ndrg3
• Organism: Mus musculus (Mouse).
• Sequence Length: 375
• Protein Sequence: MDELQDVQLTEIKPLLNDKNGTRNFQDFDCQEHDIETPHGMVHVTIRGLPKGNRPVILTYHDIGLNHKSCFNTFFNFEDMQEITQHFAVCHVDAPGQQEAAPSFPTGYQYPTMDELAEMLPPVLTHLSMKSIIGIGVGAGAYILSRFALNHPELVEGLVLINIDPCAKGWIDWAASKLSGFTTNIVDIILAHHFGQEELQANLDLIQTYRLHIAQDINQENLQLFLGSYNGRRDLEIERPILGQNDNRLKTLKCSTLLVVGDNSPAVEAVVECNSRLDPINTTLLKMADCGGLPQVVQPGKLTEAFKYFLQGMGYIPSASMTRLARSRTHSTSSSIGSGESPFSRSVTSNQSDGTQESCESPDVLDRHQTMEVSC

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MDELQDVQ -------CCCCCCCE	9.01	-
19	Ubiquitination	IKPLLNDKNGTRNFQ CHHHHCCCCCCCCCC	57.09	-
51	Ubiquitination	VTIRGLPKGNRPVIL EEECCCCCCCCCEEE	74.08	-
318	Phosphorylation	QGMGYIPSASMTRLA HHCCCCCCHHHHHHH	24.34	29899451
320	Phosphorylation	MGYIPSASMTRLARS CCCCCCHHHHHHHHC	25.64	19060867
322	Phosphorylation	YIPSASMTRLARSRT CCCCHHHHHHHHCCC	21.75	19060867
327	Phosphorylation	SMTRLARSRTHSTSS HHHHHHHCCCCCCCC	35.60	27087446
329	Phosphorylation	TRLARSRTHSTSSSI HHHHHCCCCCCCCCC	22.79	24925903
331	Phosphorylation	LARSRTHSTSSSIGS HHHCCCCCCCCCCCC	29.39	24925903
332	Phosphorylation	ARSRTHSTSSSIGSG HHCCCCCCCCCCCCC	25.64	24925903
333	Phosphorylation	RSRTHSTSSSIGSGE HCCCCCCCCCCCCCC	25.71	25521595
334	Phosphorylation	SRTHSTSSSIGSGES CCCCCCCCCCCCCCC	26.51	25521595
335	Phosphorylation	RTHSTSSSIGSGESP CCCCCCCCCCCCCCC	30.64	25521595
338	Phosphorylation	STSSSIGSGESPFSR CCCCCCCCCCCCCCC	37.40	24925903
341	Phosphorylation	SSIGSGESPFSRSVT CCCCCCCCCCCCCCC	34.47	24925903
344	Phosphorylation	GSGESPFSRSVTSNQ CCCCCCCCCCCCCCC	27.34	24925903
346	Phosphorylation	GESPFSRSVTSNQSD CCCCCCCCCCCCCCC	28.66	25619855
348	Phosphorylation	SPFSRSVTSNQSDGT CCCCCCCCCCCCCCC	24.17	25619855
349	Phosphorylation	PFSRSVTSNQSDGTQ CCCCCCCCCCCCCCH	30.62	25619855
352	Phosphorylation	RSVTSNQSDGTQESC CCCCCCCCCCCHHCC	42.11	25521595
355	Phosphorylation	TSNQSDGTQESCESP CCCCCCCCHHCCCCC	33.87	25521595
358	Phosphorylation	QSDGTQESCESPDVL CCCCCHHCCCCCCCH	17.23	25619855
361	Phosphorylation	GTQESCESPDVLDRH CCHHCCCCCCCHHHH	30.63	25521595
370	Phosphorylation	DVLDRHQTMEVSC-- CCHHHHHHCEECC--	14.80	23527152
374	Phosphorylation	RHQTMEVSC------ HHHHCEECC------	10.78	25521595

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of NDRG3_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NDRG3_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NDRG3_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of NDRG3_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Solid tumor proteome and phosphoproteome analysis by high resolutionmass spectrometry.";
Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J.,Faessler R., Mann M.;
J. Proteome Res. 7:5314-5326(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-331, AND MASSSPECTROMETRY.
PubMed: 19367708

"Large-scale phosphorylation analysis of mouse liver.";
Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-331; SER-334 ANDSER-335, AND MASS SPECTROMETRY.
PubMed: 17242355