dbPTM

LIPB1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	LIPB1_MOUSE
UniProt AC	Q8C8U0
Protein Name	Liprin-beta-1
Gene Name	Ppfibp1
Organism	Mus musculus (Mouse).
Sequence Length	969
Subcellular Localization
Protein Description	May regulate the disassembly of focal adhesions. Did not bind receptor-like tyrosine phosphatases type 2A (By similarity)..
Protein Sequence	MMSDASDMLAAALEQMDGIIAGSKALEYSNGIFDCQSPTSPFMGSLRALHLVEDLRGLLEMMETDEKEGLRCQIPDSTAEVLIEWLQNQMTNGHLPGNGDVYQERLARLENDKESLVLQVSVLTDQVEAQGEKIRDLEFCLEEHREKLNATEEMLQQELLSRTSLETQKLELMAEISNLKLKLTAVEKDRLDYEDRFRDTEGLIQEINDLRLKVNEMDGERLQYEKKLKSTKDELASLKEQLEEKECEVKRLQERLVCKAKGEGIEVLDRDIEVQKMKKAVESLMAANEEKERKIEDLRQCLSRYRKMQDPAVLAQGQDSECEGLFHSSSISTLLDAQGFSDLERSTSSTPGMGSPSRDLLHTSAPEEFHTSVLQASIPSLLPPSVDVDTCEKPKLPTKPETSFEEGDGRAILGAAAEVSLSDGVSTSSLQKSSSLGNLKKEASDGTDKAPTDSRTFGTLPPKVPGHEASVDDNPFGTRKARSSFGRGFFKIKSGKRTASAPNLAETEKETAEHLNLAGTSRSKGSQGTSPFPMSPPSPDSRKKSRGIMRLFGKLRRSQSTTFNPDDMSEPEFKRGGTRATAGPRLGWSRDLGQSNSDLDMPFAKWTKEQVCSWLAEQGLGSYLSSGKHWIISGQTLLQASQQDLEKELGIKHSLHRKKLQLALQALGSEEETNYGKLDFNWVTRWLDDIGLPQYKTQFDEGRVDGRMLHYMTVDDLLSLKVVSVLHHLSIKRAIQVLRINNFEPNCLRRRPSDENSITPSEVQQWTNHRVMEWLRSVDLAEYAPNLRGSGVHGGLMVLEPRFNVETMAQLLNIPPNKTLLRRHLATHFNLLIGAEAQHQKRDAMELPDYVLLTATAKVKPKKLTFSNFGNLRKKKHEDGEEYVCPMELGQASGSSQKGFRPGLDMRLYEEDDLDRLEQMEDSEGTVRQIGAFSEGINNLTHMLKEDDMFKDFAARSPSASITDEDSNV

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3	Phosphorylation	-----MMSDASDMLA -----CCCHHHHHHH	28.82	20469934
6	Phosphorylation	--MMSDASDMLAAAL --CCCHHHHHHHHHH	28.66	25266776
23	Phosphorylation	MDGIIAGSKALEYSN CCCEEECCHHHHHCC	13.01	25266776
28	Phosphorylation	AGSKALEYSNGIFDC ECCHHHHHCCCCCCC	14.32	26160508
29	Phosphorylation	GSKALEYSNGIFDCQ CCHHHHHCCCCCCCC	21.14	26160508
37	Phosphorylation	NGIFDCQSPTSPFMG CCCCCCCCCCCCCHH	36.15	27087446
39	Phosphorylation	IFDCQSPTSPFMGSL CCCCCCCCCCCHHHH	55.04	27087446
40	Phosphorylation	FDCQSPTSPFMGSLR CCCCCCCCCCHHHHH	21.37	27087446
45	Phosphorylation	PTSPFMGSLRALHLV CCCCCHHHHHHHHHH	11.68	26643407
283	Phosphorylation	KMKKAVESLMAANEE HHHHHHHHHHHCCHH	19.49	30482847
291	Acetylation	LMAANEEKERKIEDL HHHCCHHHHHHHHHH	57.55	-
320	Phosphorylation	VLAQGQDSECEGLFH HHHCCCCCCCCCCCC	35.94	23984901
328	Phosphorylation	ECEGLFHSSSISTLL CCCCCCCHHHHHHHH	20.60	23984901
329	Phosphorylation	CEGLFHSSSISTLLD CCCCCCHHHHHHHHH	24.11	23984901
330	Phosphorylation	EGLFHSSSISTLLDA CCCCCHHHHHHHHHC	24.47	27087446
332	Phosphorylation	LFHSSSISTLLDAQG CCCHHHHHHHHHCCC	18.23	23649490
333	Phosphorylation	FHSSSISTLLDAQGF CCHHHHHHHHHCCCC	29.66	23984901
341	Phosphorylation	LLDAQGFSDLERSTS HHHCCCCCCHHHCCC	48.38	23984901
346	Phosphorylation	GFSDLERSTSSTPGM CCCCHHHCCCCCCCC	24.22	29472430
347	Phosphorylation	FSDLERSTSSTPGMG CCCHHHCCCCCCCCC	32.68	29472430
348	Phosphorylation	SDLERSTSSTPGMGS CCHHHCCCCCCCCCC	33.20	24899341
349	Phosphorylation	DLERSTSSTPGMGSP CHHHCCCCCCCCCCC	38.42	25263469
350	Phosphorylation	LERSTSSTPGMGSPS HHHCCCCCCCCCCCC	24.51	25521595
355	Phosphorylation	SSTPGMGSPSRDLLH CCCCCCCCCCHHHCC	15.71	25521595
357	Phosphorylation	TPGMGSPSRDLLHTS CCCCCCCCHHHCCCC	39.87	28066266
398	Phosphorylation	CEKPKLPTKPETSFE CCCCCCCCCCCCCCC	70.44	25619855
402	Phosphorylation	KLPTKPETSFEEGDG CCCCCCCCCCCCCCC	47.44	26824392
403	Phosphorylation	LPTKPETSFEEGDGR CCCCCCCCCCCCCCC	29.06	26824392
420	Phosphorylation	LGAAAEVSLSDGVST EEEEEEEECCCCCCH	17.41	21743459
422	Phosphorylation	AAAEVSLSDGVSTSS EEEEEECCCCCCHHH	25.47	21743459
426	Phosphorylation	VSLSDGVSTSSLQKS EECCCCCCHHHHHCC	28.27	21743459
427	Phosphorylation	SLSDGVSTSSLQKSS ECCCCCCHHHHHCCC	21.67	21743459
428	Phosphorylation	LSDGVSTSSLQKSSS CCCCCCHHHHHCCCC	22.88	21743459
429	Phosphorylation	SDGVSTSSLQKSSSL CCCCCHHHHHCCCCC	34.60	21743459
433	Phosphorylation	STSSLQKSSSLGNLK CHHHHHCCCCCCCCC	16.52	23429704
434	Phosphorylation	TSSLQKSSSLGNLKK HHHHHCCCCCCCCCH	36.30	20531401
435	Phosphorylation	SSLQKSSSLGNLKKE HHHHCCCCCCCCCHH	47.60	26824392
470	Phosphorylation	KVPGHEASVDDNPFG CCCCCCCCCCCCCCC	24.08	18846507
478	Phosphorylation	VDDNPFGTRKARSSF CCCCCCCCHHHHHHC	29.40	18846507
483	Phosphorylation	FGTRKARSSFGRGFF CCCHHHHHHCCCCEE	34.57	26824392
484	Phosphorylation	GTRKARSSFGRGFFK CCHHHHHHCCCCEEE	26.60	23737553
494	Phosphorylation	RGFFKIKSGKRTASA CCEEEECCCCCCCCC	53.68	29514104
498	Phosphorylation	KIKSGKRTASAPNLA EECCCCCCCCCCCHH	28.57	27087446
500	Phosphorylation	KSGKRTASAPNLAET CCCCCCCCCCCHHHH	43.58	25521595
507	Phosphorylation	SAPNLAETEKETAEH CCCCHHHHHHHHHHH	46.91	25619855
511	Phosphorylation	LAETEKETAEHLNLA HHHHHHHHHHHHHCC	48.70	24719451
520	Phosphorylation	EHLNLAGTSRSKGSQ HHHHCCCCCCCCCCC	18.50	26824392
521	Phosphorylation	HLNLAGTSRSKGSQG HHHCCCCCCCCCCCC	33.37	29514104
523	Phosphorylation	NLAGTSRSKGSQGTS HCCCCCCCCCCCCCC	40.93	25619855
526	Phosphorylation	GTSRSKGSQGTSPFP CCCCCCCCCCCCCCC	29.22	25619855
529	Phosphorylation	RSKGSQGTSPFPMSP CCCCCCCCCCCCCCC	26.11	25619855
530	Phosphorylation	SKGSQGTSPFPMSPP CCCCCCCCCCCCCCC	31.22	25619855
535	Phosphorylation	GTSPFPMSPPSPDSR CCCCCCCCCCCCCCH	33.62	27742792
538	Phosphorylation	PFPMSPPSPDSRKKS CCCCCCCCCCCHHHH	44.73	25521595
541	Phosphorylation	MSPPSPDSRKKSRGI CCCCCCCCHHHHHHH	49.75	27742792
549	Phosphorylation	RKKSRGIMRLFGKLR HHHHHHHHHHHHHHH	3.20	24719451
554	Acetylation	GIMRLFGKLRRSQST HHHHHHHHHHHCCCC	31.33	19865959
558	Phosphorylation	LFGKLRRSQSTTFNP HHHHHHHCCCCCCCC	23.27	25521595
560	Phosphorylation	GKLRRSQSTTFNPDD HHHHHCCCCCCCCCC	30.57	27087446
561	Phosphorylation	KLRRSQSTTFNPDDM HHHHCCCCCCCCCCC	27.98	27742792
562	Phosphorylation	LRRSQSTTFNPDDMS HHHCCCCCCCCCCCC	27.02	27087446
568	Oxidation	TTFNPDDMSEPEFKR CCCCCCCCCCCCHHC	6.79	17242355
569	Phosphorylation	TFNPDDMSEPEFKRG CCCCCCCCCCCHHCC	57.92	25619855
574 (in isoform 3)	Ubiquitination	-	48.77	22790023
574	Ubiquitination	DMSEPEFKRGGTRAT CCCCCCHHCCCCCCC	48.77	22790023
578	Phosphorylation	PEFKRGGTRATAGPR CCHHCCCCCCCCCCC	21.69	29514104
581	Phosphorylation	KRGGTRATAGPRLGW HCCCCCCCCCCCCCC	28.93	26824392
585 (in isoform 3)	Ubiquitination	-	44.94	-
589	Phosphorylation	AGPRLGWSRDLGQSN CCCCCCCCCCCCCCC	17.70	23984901
595	Phosphorylation	WSRDLGQSNSDLDMP CCCCCCCCCCCCCCC	36.18	25521595
597	Phosphorylation	RDLGQSNSDLDMPFA CCCCCCCCCCCCCHH	44.81	27087446
601	Oxidation	QSNSDLDMPFAKWTK CCCCCCCCCHHHCCH	3.70	17242355
654	Phosphorylation	KELGIKHSLHRKKLQ HHHCCCHHHHHHHHH	22.37	25338131
713	Phosphorylation	GRMLHYMTVDDLLSL CEEEEEEEHHHHHHH	17.39	-
753	Phosphorylation	NCLRRRPSDENSITP CCCCCCCCCCCCCCH	56.60	26824392
757	Phosphorylation	RRPSDENSITPSEVQ CCCCCCCCCCHHHHH	26.28	26824392
759	Phosphorylation	PSDENSITPSEVQQW CCCCCCCCHHHHHHH	22.15	26160508
764	Phosphorylation	SITPSEVQQWTNHRV CCCHHHHHHHHHHHH	29.10	24719451
865	Phosphorylation	KVKPKKLTFSNFGNL CCCCCCCCCCCCCCC	33.62	29514104
867	Phosphorylation	KPKKLTFSNFGNLRK CCCCCCCCCCCCCCC	26.47	-
878	Phosphorylation	NLRKKKHEDGEEYVC CCCCEECCCCCCEEC	76.28	24719451
896	Phosphorylation	LGQASGSSQKGFRPG CCCCCCCCCCCCCCC	39.16	25338131
909	Phosphorylation	PGLDMRLYEEDDLDR CCCCCEEEECCCHHH	13.60	25159016
923	Phosphorylation	RLEQMEDSEGTVRQI HHHHHCCCCCCHHHH	25.31	25159016
957	Phosphorylation	FKDFAARSPSASITD HHHHHHHCCCCCCCC	20.62	27087446
959	Phosphorylation	DFAARSPSASITDED HHHHHCCCCCCCCCC	35.58	25521595
961	Phosphorylation	AARSPSASITDEDSN HHHCCCCCCCCCCCC	30.29	27087446
963	Phosphorylation	RSPSASITDEDSNV- HCCCCCCCCCCCCC-	30.73	27087446
967	Phosphorylation	ASITDEDSNV----- CCCCCCCCCC-----	37.13	25521595

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of LIPB1_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of LIPB1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of LIPB1_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of LIPB1_MOUSE !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of LIPB1_MOUSE

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Large scale localization of protein phosphorylation by use ofelectron capture dissociation mass spectrometry."; Sweet S.M., Bailey C.M., Cunningham D.L., Heath J.K., Cooper H.J.; Mol. Cell. Proteomics 8:904-912(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-538 AND SER-560, ANDMASS SPECTROMETRY.	19131326 [Abstract]
"The phagosomal proteome in interferon-gamma-activated macrophages."; Trost M., English L., Lemieux S., Courcelles M., Desjardins M.,Thibault P.; Immunity 30:143-154(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-435, AND MASSSPECTROMETRY.	19144319 [Abstract]
"Large-scale phosphorylation analysis of mouse liver."; Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-560, AND MASSSPECTROMETRY.	17242355 [Abstract]