DTNA_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: DTNA_MOUSE
• UniProt AC: Q9D2N4
• Protein Name: Dystrobrevin alpha
• Gene Name: Dtna
• Organism: Mus musculus (Mouse).
• Sequence Length: 746
• Subcellular Localization: Cytoplasm . Cell junction, synapse . Cell membrane . In peripheral nerves, colocalizes with MAGEE1 in the Schwann cell membrane.
• Protein Description: Involved in synapse maturation and required for normal muscle function..
• Protein Sequence: MIEDSGKRGNTMAERRQLFAEMRAQDLDRIRLSTYRTACKLRFVQKKCNLHLVDIWNVIEALRENALNNLDPNIELNVARLEAVLSTIFYQLNKRMPTTHQIHVEQSISLLLNFLLAAFDPEGHGKISVFAVKMALATLCGGKIMDKLRYIFSMISDSSGVMVYGRYDQFLREVLKLPTAVFEGPSFGYTEQSARSCFSQQKKVTLNGFLDTLMSDPPPQCLVWLPLLHRLANVENVFHPVECSYCHSESMMGFRYRCQQCHNYQLCQDCFWRGHAGGSHSNQHQMKEYTSWKSPAKKLTNALSKSLSCASSREPLHPMFPDQPEKPLNLAHIVPPRPVTSMNDTLFSHSVPSSGSPFITRSSPPKDSEVEQNKMLARAAPAFLKGRGIQYSLNVADRLADEHVLIGLYVNMLRNDPPCMLESSNRLDEEHRLIARYAARLAAESSSSQPTQQRSAPDISFTIDANKQQRQLIAELENKNREILQEIQRLRVEHEQASQPTPEKAQQNPTLLAELRLLRQRKDELEQRMSALQESRRELMVQLEGLMKLLKEEELKQGTQGASSPRSSPSHTISRPIPMPIRSASACPTPTHTPQDSLTGVGGDVQEAFAQSSRRNLRSDLLVAADSITNTMSSLVKELNSEVASETESTVDSEFSRPQFEDLAPSPTSEKAFLAQIHSRKPGYIHGGAASTTHGDMVPEDGDPYTQPEDGNYENESVRQLENELQLEEYLKQKLQDEAYQVSLQG

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
7	Ubiquitination	-MIEDSGKRGNTMAE -CCCCCCCCCCCHHH	62.17	22790023
202	Ubiquitination	RSCFSQQKKVTLNGF HHHHHCCCCEEHHHH	41.39	22790023
267	S-palmitoylation	QCHNYQLCQDCFWRG HCCCCCCCCHHCCCC	1.57	28680068
290	Phosphorylation	QHQMKEYTSWKSPAK HHHHHHHCCCCCHHH	29.24	29514104
294	Phosphorylation	KEYTSWKSPAKKLTN HHHCCCCCHHHHHHH	24.67	29899451
304	Phosphorylation	KKLTNALSKSLSCAS HHHHHHHHHHHCCCC	20.14	22324799
305	Ubiquitination	KLTNALSKSLSCASS HHHHHHHHHHCCCCC	57.15	22790023
306	Phosphorylation	LTNALSKSLSCASSR HHHHHHHHHCCCCCC	23.34	25521595
308	Phosphorylation	NALSKSLSCASSREP HHHHHHHCCCCCCCC	18.09	24899341
348	Phosphorylation	SMNDTLFSHSVPSSG CCCCCCCCCCCCCCC	20.26	-
353	Phosphorylation	LFSHSVPSSGSPFIT CCCCCCCCCCCCCCC	45.21	23737553
354	Phosphorylation	FSHSVPSSGSPFITR CCCCCCCCCCCCCCC	36.90	23737553
356	Phosphorylation	HSVPSSGSPFITRSS CCCCCCCCCCCCCCC	20.70	23737553
360	Phosphorylation	SSGSPFITRSSPPKD CCCCCCCCCCCCCCC	25.52	23737553
362 (in isoform 2)	Phosphorylation	-	38.25	26824392
362	Phosphorylation	GSPFITRSSPPKDSE CCCCCCCCCCCCCCH	38.25	23737553
363	Phosphorylation	SPFITRSSPPKDSEV CCCCCCCCCCCCCHH	41.76	23737553
365 (in isoform 7)	Phosphorylation	-	55.84	26824392
368	Phosphorylation	RSSPPKDSEVEQNKM CCCCCCCCHHHHHHH	50.06	21183079
374	Ubiquitination	DSEVEQNKMLARAAP CCHHHHHHHHHHHHH	34.68	22790023
385	Ubiquitination	RAAPAFLKGRGIQYS HHHHHHHCCCCCCCC	39.86	22790023
392	Phosphorylation	KGRGIQYSLNVADRL CCCCCCCCCCHHHHH	9.33	28464351
423	Phosphorylation	DPPCMLESSNRLDEE CCCCCCCCCCCCCHH	29.02	30635358
424	Phosphorylation	PPCMLESSNRLDEEH CCCCCCCCCCCCHHH	19.32	30635358
455	Phosphorylation	SQPTQQRSAPDISFT CCCCCCCCCCCCEEE	39.55	25619855
467	Ubiquitination	SFTIDANKQQRQLIA EEEECCCHHHHHHHH	49.91	22790023
498	Phosphorylation	RVEHEQASQPTPEKA HHHHHHHCCCCHHHH	36.07	27742792
500	Phosphorylation	EHEQASQPTPEKAQQ HHHHHCCCCHHHHHH	47.64	24719451
501	Phosphorylation	HEQASQPTPEKAQQN HHHHCCCCHHHHHHC	36.12	26824392
503	Phosphorylation	QASQPTPEKAQQNPT HHCCCCHHHHHHCHH	64.60	24719451
506 (in isoform 2)	Phosphorylation	-	55.43	29514104
510	Phosphorylation	EKAQQNPTLLAELRL HHHHHCHHHHHHHHH	41.79	25338131
512 (in isoform 2)	Phosphorylation	-	3.71	29514104
530	Phosphorylation	DELEQRMSALQESRR HHHHHHHHHHHHHHH	28.19	28507225
559	Phosphorylation	EEELKQGTQGASSPR HHHHHHCCCCCCCCC	22.72	29899451
563	Phosphorylation	KQGTQGASSPRSSPS HHCCCCCCCCCCCCC	47.93	29899451
564	Phosphorylation	QGTQGASSPRSSPSH HCCCCCCCCCCCCCC	24.65	28542873
567	Phosphorylation	QGASSPRSSPSHTIS CCCCCCCCCCCCCCC	50.41	23737553
568	Phosphorylation	GASSPRSSPSHTISR CCCCCCCCCCCCCCC	31.53	23737553
570	Phosphorylation	SSPRSSPSHTISRPI CCCCCCCCCCCCCCC	34.90	29514104
572	Phosphorylation	PRSSPSHTISRPIPM CCCCCCCCCCCCCCC	25.61	29899451
585	Phosphorylation	PMPIRSASACPTPTH CCCCCCCCCCCCCCC	31.48	29899451
587	S-palmitoylation	PIRSASACPTPTHTP CCCCCCCCCCCCCCC	3.41	28680068
589	Phosphorylation	RSASACPTPTHTPQD CCCCCCCCCCCCCCH	40.48	19060867
591	Phosphorylation	ASACPTPTHTPQDSL CCCCCCCCCCCCHHC	40.64	29899451
593	Phosphorylation	ACPTPTHTPQDSLTG CCCCCCCCCCHHCCC	25.73	19060867
597	Phosphorylation	PTHTPQDSLTGVGGD CCCCCCHHCCCCCHH	23.68	29899451
599	Phosphorylation	HTPQDSLTGVGGDVQ CCCCHHCCCCCHHHH	33.50	29899451
627	Phosphorylation	DLLVAADSITNTMSS HHHHHHHHHHHHHHH	26.96	29899451
641	Phosphorylation	SLVKELNSEVASETE HHHHHHHHHHHHCCC	46.18	25619855
645	Phosphorylation	ELNSEVASETESTVD HHHHHHHHCCCHHCC	50.67	25619855
647	Phosphorylation	NSEVASETESTVDSE HHHHHHCCCHHCCCC	32.51	25619855
649	Phosphorylation	EVASETESTVDSEFS HHHHCCCHHCCCCCC	40.94	25619855
650	Phosphorylation	VASETESTVDSEFSR HHHCCCHHCCCCCCC	23.31	25619855
653	Phosphorylation	ETESTVDSEFSRPQF CCCHHCCCCCCCCCH	35.88	25619855
666	Phosphorylation	QFEDLAPSPTSEKAF CHHHCCCCCCCHHHH	34.89	21082442
668	Phosphorylation	EDLAPSPTSEKAFLA HHCCCCCCCHHHHHH	54.58	25619855
669	Phosphorylation	DLAPSPTSEKAFLAQ HCCCCCCCHHHHHHH	40.25	25619855
679	Phosphorylation	AFLAQIHSRKPGYIH HHHHHHHCCCCCEEC	43.56	22807455
743	Phosphorylation	QDEAYQVSLQG---- HHHHHHHHCCC----	10.23	25338131

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of DTNA_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of DTNA_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of DTNA_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of DTNA_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.