KAZRN_MOUSE - dbPTM
KAZRN_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID KAZRN_MOUSE
UniProt AC Q69ZS8
Protein Name Kazrin
Gene Name Kazn
Organism Mus musculus (Mouse).
Sequence Length 779
Subcellular Localization Cell junction . Nucleus . Cytoplasm, cytoskeleton . In an antibody regognizing isoform 2 and isoform 3 has been used.
Protein Description Component of the cornified envelope of keratinocytes. May be involved in the interplay between adherens junctions and desmosomes. The function in the nucleus is not known..
Protein Sequence MMEDNKQLALRIDGAVQSASQEVTNLRAELTATNRRLAELSGGGGGPGSGPGAATSASAAAVTVADSAVATMENHQHGAQVLLREEVVQLQEEVHLLRQMKEMLAKDLEESQGGKCSEVLSATELRVQLVQKEQELARAKEALQAMKADRKRLKGEKTDLVSQMQQLYATLESREEQLRDFIRNYEQHRKESEDAVKALAKEKDLLEREKWELRRQAKEATDHAAALRSQLDLKDNRMKELEAELAMAKQSLATLTKDVPKRHSLAMPGETVLNGNQEWVVQADLPLTAAIRQSQQTLYHSHPPHPADRQVRVSPCHSRQPSVISDASAAEGDRSSTPSDINSPRHRTHSLCNGDSPGPVQKSLHNPIVQSLEDLEDQKRKKKKEKMGFGSISRVFARGKQRKSLDPGLFDDSDSQCSPTRHSLSLSEGEEQMDRLQHVELVRTTPMSHWKAGTVQAWLEVVMAMPMYVKACAENVKSGKVLLSLSDEDLELGLGVCSSLHRRKLRLAIEDYRDAEAGRSLSKAADLDHHWVAKAWLNDIGLSQYSQAFQNHLVDGRMLNSLMKRDLEKHLNVSKKFHQVSILLGIELLYQVNFSREALQERRARCETQNTDPVVWTNQRVLKWVRDIDLKEYADNLTNSGVHGAVLVLEPTFNAEAMATALGIPSGKHILRRHLAEEMSTIFHPSNSTGIRESERFGTPPGRASSITRAGREDSGGNSKHRAGRLPLGKIGRGFSSKEPDFHDDYGSLENEDCGDEDLQGRPEQCRLEGYGSLEVTNV
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
6 (in isoform 2)Phosphorylation-60.0420415495
8 (in isoform 2)Phosphorylation-5.3121183079
58PhosphorylationPGAATSASAAAVTVA
CCHHCCHHHHHHHHC		20.4326239621
63PhosphorylationSASAAAVTVADSAVA
CHHHHHHHHCHHHHH		12.7826239621
67PhosphorylationAAVTVADSAVATMEN
HHHHHCHHHHHHHHC		18.2026239621
115UbiquitinationLEESQGGKCSEVLSA
HHHHCCCCHHHHHHH		41.2222790023
264PhosphorylationKDVPKRHSLAMPGET
CCCCCCCCCCCCCCE		23.12-
305 (in isoform 3)Phosphorylation-34.3326643407
314 (in isoform 3)Phosphorylation-15.9626643407
314PhosphorylationADRQVRVSPCHSRQP
CCCEEEEECCCCCCC		15.9625195567
318PhosphorylationVRVSPCHSRQPSVIS
EEEECCCCCCCCHHC		39.0529899451
322PhosphorylationPCHSRQPSVISDASA
CCCCCCCCHHCCCHH		24.6025521595
328PhosphorylationPSVISDASAAEGDRS
CCHHCCCHHCCCCCC		32.7629899451
335PhosphorylationSAAEGDRSSTPSDIN
HHCCCCCCCCCHHCC		43.2223527152
336PhosphorylationAAEGDRSSTPSDINS
HCCCCCCCCCHHCCC		45.2725521595
337PhosphorylationAEGDRSSTPSDINSP
CCCCCCCCCHHCCCC		28.2325521595
339PhosphorylationGDRSSTPSDINSPRH
CCCCCCCHHCCCCCC		51.7330635358
343PhosphorylationSTPSDINSPRHRTHS
CCCHHCCCCCCCCCC		24.5225521595
348PhosphorylationINSPRHRTHSLCNGD
CCCCCCCCCCCCCCC		15.0827087446
350PhosphorylationSPRHRTHSLCNGDSP
CCCCCCCCCCCCCCC		33.7219060867
356PhosphorylationHSLCNGDSPGPVQKS
CCCCCCCCCCCCCHH		32.9125521595
363PhosphorylationSPGPVQKSLHNPIVQ
CCCCCCHHHCCHHHH		20.1229899451
371PhosphorylationLHNPIVQSLEDLEDQ
HCCHHHHCHHHHHHH		23.8826239621
391PhosphorylationKEKMGFGSISRVFAR
HHHHCCCHHHHHHHC		18.3526643407
393PhosphorylationKMGFGSISRVFARGK
HHCCCHHHHHHHCCC		24.8826643407
393 (in isoform 2)Phosphorylation-24.8826643407
402 (in isoform 2)Phosphorylation-33.7326643407
404PhosphorylationARGKQRKSLDPGLFD
HCCCCCCCCCCCCCC		39.9529899451
445PhosphorylationHVELVRTTPMSHWKA
HHEEEECCCCCCCCC		13.3620139300
448PhosphorylationLVRTTPMSHWKAGTV
EEECCCCCCCCCCHH		27.6527841257
694PhosphorylationNSTGIRESERFGTPP
CCCCCCHHHHHCCCC		24.9929899451
699PhosphorylationRESERFGTPPGRASS
CHHHHHCCCCCCHHH		24.4919060867
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of KAZRN_MOUSE !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of KAZRN_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of KAZRN_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of KAZRN_MOUSE !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of KAZRN_MOUSE

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Solid tumor proteome and phosphoproteome analysis by high resolutionmass spectrometry.";
Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J.,Faessler R., Mann M.;
J. Proteome Res. 7:5314-5326(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-350 AND SER-371, ANDMASS SPECTROMETRY.

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