TCPR1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TCPR1_MOUSE
• UniProt AC: Q80VP0
• Protein Name: Tectonin beta-propeller repeat-containing protein 1
• Gene Name: Tecpr1
• Organism: Mus musculus (Mouse).
• Sequence Length: 1166
• Subcellular Localization: Cytoplasmic vesicle, autophagosome membrane. Lysosome membrane. Localizes to Lysosome membranes, and binds PtdIns(3)P at the surface of autophagosome. Localizes to autolysosomes, a vesicle formed by the fusion between autophagosomes and lysosomes (By
• Protein Description: Tethering factor involved in autophagy. Involved in autophagosome maturation by promoting the autophagosome fusion with lysosomes: acts by associating with both the ATG5-ATG12 conjugate and phosphatidylinositol-3-phosphate (PtdIns(3)P) present at the surface of autophagosomes. Also involved in selective autophagy against bacterial pathogens, by being required for phagophore/preautophagosomal structure biogenesis and maturation (By similarity)..
• Protein Sequence: MPTSVLWAVDLFGRVYTLSTAGQYWELCKDVQLEFKRVSAATQCCWGIAGDNQVYLYVCSSDVPIRHREEAYENQRWNPMGGFCEKLLPSDRWPWSDVSGLQHRPLDGVALPSPHWEWESDWYVDENFGGEPTEKGGWTYAMDFPATYTRDKKWNSCVRRRKWIRYRRYKSRDSWAKIPSKDDPKELPDPFNDLSVGGWEITEEPVGRLSVWAVSLQGKVWYREDVSHPNPEGSSWSLVETPGEVVQISCGPHDLIWATLWEGQALVREGVCRNNPKGSYWSMVEPPGSENGIMHVSAGVSVVWAITKDRKVWFRRGVNSHNPCGTSWIEMVGEMTMVNVGLNDQVWGISCEDRAVYFRQGVTPSELSGKTWKAIVVGRESDRSHSGSSSSLLSAGCFFGDEVRGSGTESAPSDTDASLEVERQGPEQPLPKEALDNSTNLKGSLSKGHETSGNTDHSTENACLTEGKEKAPETSRSDECRGPASTPAELPWTNIDLKEPKKVSNQPAAGFPETAGLSSLGLFPMGMEEPYGADDHPLWAWVSGGACAVEAGSTLKWFTIQSGLSPSVQTLSLSITPAQTAAWRKQIFQQLTERTKRELESFRHYEQAVEQSVWVKTGALQWWCDWKPHKWVDVRVALEQFTGHDGARDSILFIYYVVHEEKKYLHVFLNEVTVLVPVLNEAKHSFALYTPERTRQRWPVRLAAATEQDMNDWLALLSLSCCESRKVHGRPSPQAIWSVTCKGDIFVSEPSPDLEARERLLPCDQMFWRQMGGHLRIIEANSRGVVWGIGYDHTAWVYTGGYGGGCFQGLASSTSNIYTQSDVKSVYIYENQRWNPVTGYTSRGLPTDRFMWSDVTGLQECTKAGTKPPSLQWTWVSDWYVDFSVPGGTDQEGWQYASDFPASYHGYKTMKDFVRRRCWARKCKLVTSGPWLEVAPITLSDVSIIPESAHADGRGHNVALWAVSDKGDVLCRLGVSELNPAGSSWLHVGTDQPFASVSIGACYQVWAVARDGSAFYRGSVSPSQPAGDCWYHIPSPPKQKLTQVSVGQTSVYALDENGNLWYRAGITPSYPQGSSWEHVSNNVRKVSVGPLDQVWVIANKVQGSHGLSRGTVCRRMGVQPREPKGQGWDYGIGGGWDHISVRANATRVPRNMSRDREARGPGPVCC

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
36	Ubiquitination	KDVQLEFKRVSAATQ HHCEEHHHCHHCHHC	42.38	22790023
36	Acetylation	KDVQLEFKRVSAATQ HHCEEHHHCHHCHHC	42.38	6566997
147	Phosphorylation	YAMDFPATYTRDKKW EEEECCCEECCCCCH	26.18	21189417
381	Phosphorylation	AIVVGRESDRSHSGS EEEECCCCCCCCCCC	36.64	19060867
384	Phosphorylation	VGRESDRSHSGSSSS ECCCCCCCCCCCCHH	27.31	19060867
386	Phosphorylation	RESDRSHSGSSSSLL CCCCCCCCCCCHHHH	41.43	22817900
388	Phosphorylation	SDRSHSGSSSSLLSA CCCCCCCCCHHHHCC	30.02	22817900
389	Phosphorylation	DRSHSGSSSSLLSAG CCCCCCCCHHHHCCC	27.72	22817900
390	Phosphorylation	RSHSGSSSSLLSAGC CCCCCCCHHHHCCCC	27.05	21183079
391	Phosphorylation	SHSGSSSSLLSAGCF CCCCCCHHHHCCCCC	34.97	22817900
394	Phosphorylation	GSSSSLLSAGCFFGD CCCHHHHCCCCCCCC	28.10	23984901
406	Phosphorylation	FGDEVRGSGTESAPS CCCCCCCCCCCCCCC	31.79	28833060
408	Phosphorylation	DEVRGSGTESAPSDT CCCCCCCCCCCCCCC	28.59	28833060
410	Phosphorylation	VRGSGTESAPSDTDA CCCCCCCCCCCCCCC	45.37	28833060
413	Phosphorylation	SGTESAPSDTDASLE CCCCCCCCCCCCCCE	53.51	25521595
415	Phosphorylation	TESAPSDTDASLEVE CCCCCCCCCCCCEEH	37.49	28833060
418	Phosphorylation	APSDTDASLEVERQG CCCCCCCCCEEHHCC	28.07	25521595
438	Phosphorylation	PKEALDNSTNLKGSL CHHHHCCCCCCCCCC	20.52	22817900
439	Phosphorylation	KEALDNSTNLKGSLS HHHHCCCCCCCCCCC	51.31	30635358
444	Phosphorylation	NSTNLKGSLSKGHET CCCCCCCCCCCCCCC	28.07	22817900
446	Phosphorylation	TNLKGSLSKGHETSG CCCCCCCCCCCCCCC	37.98	29176673
451	O-linked_Glycosylation	SLSKGHETSGNTDHS CCCCCCCCCCCCCCC	35.94	30016717
451	Phosphorylation	SLSKGHETSGNTDHS CCCCCCCCCCCCCCC	35.94	30635358
452	O-linked_Glycosylation	LSKGHETSGNTDHST CCCCCCCCCCCCCCC	27.36	30016717
452	Phosphorylation	LSKGHETSGNTDHST CCCCCCCCCCCCCCC	27.36	30635358
455	Phosphorylation	GHETSGNTDHSTENA CCCCCCCCCCCCCCC	38.32	30635358
458	O-linked_Glycosylation	TSGNTDHSTENACLT CCCCCCCCCCCCCCC	39.98	30016717
458	Phosphorylation	TSGNTDHSTENACLT CCCCCCCCCCCCCCC	39.98	30387612
459	Phosphorylation	SGNTDHSTENACLTE CCCCCCCCCCCCCCC	29.82	30635358
459	O-linked_Glycosylation	SGNTDHSTENACLTE CCCCCCCCCCCCCCC	29.82	30016717
465	Phosphorylation	STENACLTEGKEKAP CCCCCCCCCCHHHCC	42.44	30635358
485	Phosphorylation	DECRGPASTPAELPW CCCCCCCCCCCCCCC	37.75	28066266
486	Phosphorylation	ECRGPASTPAELPWT CCCCCCCCCCCCCCC	28.73	28066266
585	Ubiquitination	AQTAAWRKQIFQQLT HHHHHHHHHHHHHHH	36.72	22790023
601	Phosphorylation	RTKRELESFRHYEQA HHHHHHHHHHHHHHH	39.96	29899451
718	Phosphorylation	NDWLALLSLSCCESR HHHHHHHHHHHHHHC	21.06	28285833
720	Phosphorylation	WLALLSLSCCESRKV HHHHHHHHHHHHCCC	17.22	28285833
724	Phosphorylation	LSLSCCESRKVHGRP HHHHHHHHCCCCCCC	24.40	28285833
748	Phosphorylation	CKGDIFVSEPSPDLE ECCCEEECCCCCCHH	32.80	20415495
751	Phosphorylation	DIFVSEPSPDLEARE CEEECCCCCCHHHHH	27.31	22817900
943	Phosphorylation	PITLSDVSIIPESAH CEEHHHEEECCHHHC	21.57	-
1087	Phosphorylation	SNNVRKVSVGPLDQV HCCCEEEEEECHHHE	25.13	-
1142	Methylation	GWDHISVRANATRVP CCCCEEEECCCCCCC	18.48	18964489
1142	Dimethylation	GWDHISVRANATRVP CCCCEEEECCCCCCC	18.48	-
1153	Phosphorylation	TRVPRNMSRDREARG CCCCCCCCCCCCCCC	34.28	22324799
1154	Methylation	RVPRNMSRDREARGP CCCCCCCCCCCCCCC	35.92	18964499
1154	Dimethylation	RVPRNMSRDREARGP CCCCCCCCCCCCCCC	35.92	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TCPR1_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TCPR1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TCPR1_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of TCPR1_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.