| UniProt ID | MIO_MOUSE | |
|---|---|---|
| UniProt AC | Q8VE19 | |
| Protein Name | GATOR complex protein MIOS {ECO:0000305} | |
| Gene Name | Mios {ECO:0000312|MGI:MGI:2182066} | |
| Organism | Mus musculus (Mouse). | |
| Sequence Length | 875 | |
| Subcellular Localization | Lysosome membrane . | |
| Protein Description | As a component of the GATOR subcomplex GATOR2, functions within the amino acid-sensing branch of the TORC1 signaling pathway. Indirectly activates mTORC1 and the TORC1 signaling pathway through the inhibition of the GATOR1 subcomplex. It is negatively regulated by the upstream amino acid sensors SESN2 and CASTOR1.. | |
| Protein Sequence | MSGTKPDILWAPHQVDRFVVCDSELSLYHVESAVNSELKAGSLRLSEDSAATLLSINSDTPYMKCVAWYLNYDPECLLAVGQANGRVVLTSLGQDHNSKFKDLIGKEFVPKHARQCNTLAWNPLDSNWLAAGLDKHRADFSVLIWDICSKYTPDIVPMEKVRLSAGEAETTLLVTKPLYELGQNDASLSLCWLPRDQKLLLAGMHRNLAIFDLRNTSQKMFVNTKAVQGVTVDPYFHDRVASFYEGQVAIWDLRKFEKPVLTLTEQPKPLTKVAWCPTRTGLLATLTRDSNIIRLYDMQHTPTPIGDETEPTIIERSVQPCDNYIASFAWHPTSQNRMIVVTPNRTMSDFTVFERISLAWSPITSLMWACGRHLYECAEEESDNSLEKDIATKMRLRALSRYGLDTEQVWRNHILAGNEDPQLKSLWYTLHFMKQYTEDNDQKSPGNKGSLVYAGIKSIVKSSLGMVESSRHNWSGLDKQTDIQNLNEERILALQLCGWIKKGTDVDVGPFLNSLVQEGEWERAAAVALFNLDIRRAIQILNEGASSEKGDLNLNVVAMALSGYTDEKNSLWREMCSTLRLQLNNPYLCVMFAFLTSEAGAYDGVLYENKVAVRDRVAFACKFLGDAQLNKYIEKLTNEMKEAGNLEGILLTGLTKDGVDLMESYVDRTGDVQTASYCMLQGSPLDVLKDERVQYWIENYRNLLDAWRFWHKRAEFDIHRSKLDPSSKPLAQVFVSCNFCGKSISYSCSSVPHQGRGFSQYGVSGSPTKSKVTSCPGCRKPLPRCALCLINMGTPVSSCPGGSKSDEKVDLSKDKKLAQFNNWFTWCHNCRHGGHAGHMLSWFRDHAECPVSACTCKCMQLDTTGNLVPAETVQP | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 160 | Ubiquitination | PDIVPMEKVRLSAGE CCCCCHHHEEECCCC | 26.80 | 22790023 | |
| 303 | Phosphorylation | YDMQHTPTPIGDETE EECCCCCCCCCCCCC | 28.79 | - | |
| 324 | Phosphorylation | SVQPCDNYIASFAWH CCCCCCCEEEEEEEC | 5.66 | 26026062 | |
| 334 | Phosphorylation | SFAWHPTSQNRMIVV EEEECCCCCCCEEEE | 29.88 | 26026062 | |
| 437 | Phosphorylation | LHFMKQYTEDNDQKS HHHHHHHCCCCCCCC | 34.08 | 28285833 | |
| 444 | Phosphorylation | TEDNDQKSPGNKGSL CCCCCCCCCCCCCCH | 32.19 | 23684622 | |
| 479 | Ubiquitination | HNWSGLDKQTDIQNL CCCCCCCCCCCCCCC | 61.20 | 22790023 | |
| 683 | Phosphorylation | SYCMLQGSPLDVLKD EEEEECCCCCCHHCH | 14.88 | 22324799 | |
| 750 | Phosphorylation | SISYSCSSVPHQGRG EEEEECCCCCCCCCC | 43.95 | 23684622 | |
| 759 | Phosphorylation | PHQGRGFSQYGVSGS CCCCCCCCCCCCCCC | 25.89 | 25619855 | |
| 761 | Phosphorylation | QGRGFSQYGVSGSPT CCCCCCCCCCCCCCC | 20.49 | 25619855 | |
| 764 | Phosphorylation | GFSQYGVSGSPTKSK CCCCCCCCCCCCCCC | 29.23 | 23684622 | |
| 766 | Phosphorylation | SQYGVSGSPTKSKVT CCCCCCCCCCCCCCC | 23.14 | 25521595 | |
| 768 | Phosphorylation | YGVSGSPTKSKVTSC CCCCCCCCCCCCCCC | 50.04 | 25521595 | |
| 769 | Ubiquitination | GVSGSPTKSKVTSCP CCCCCCCCCCCCCCC | 52.22 | 22790023 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of MIO_MOUSE !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of MIO_MOUSE !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of MIO_MOUSE !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of MIO_MOUSE !! | ||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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