ATLA1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ATLA1_MOUSE
• UniProt AC: Q8BH66
• Protein Name: Atlastin-1
• Gene Name: Atl1
• Organism: Mus musculus (Mouse).
• Sequence Length: 558
• Subcellular Localization: Endoplasmic reticulum membrane ; Multi-pass membrane protein . Golgi apparatus membrane ; Multi-pass membrane protein . Cell projection, axon . Localizes to endoplasmic reticulum tubular network.
• Protein Description: GTPase tethering membranes through formation of trans-homooligomers and mediating homotypic fusion of endoplasmic reticulum membranes. Functions in endoplasmic reticulum tubular network biogenesis. May also regulate Golgi biogenesis. May regulate axonal development..
• Protein Sequence: MAKSRRDRNSWGGFSEKSSDWSSEEEEPVRKAGPVQVLIVKDDHSFELDEAALNRILLSQAVRDKEVVAVSVAGAFRKGKSFLMDFMLRYMYNQESVDWVGDYNEPLTGFSWRGGSERETTGIQIWSEVFLINKLDGKKVAVLLMDTQGTFDSQSTLRDSATVFALSTMISSIQVYNLSQNVQEDDLQHLQLFTEYGRLAMEETFLKPFQSLIFLVRDWSFPYEFSYGADGGAKFLEKRLKVSGNQHEELQNVRKHIHSCFTNISCFLLPHPGLKVATNPNFDGKLKEIDDEFIKNLKILIPWLLSPERLDIKEINGNKITCRGLLEYFKAYIKIYQGEELPHPKSMLQATAEANNLAAVATAKDTYNKKMEEVCGGDKPFLAPNDLQSKHLQLKEESVKLFRGVKKMGGEEFSRRYLQQLESEIDELYIQYIKHNDSKNIFHAARTPATLFVVIFITYVIAGVTGFIGLDIIASLCNMIMGLTLITLCTWAYIRYSGEYRELGAVIDQVAAALWDQGSTNEALYKLYSAAATHRHLCHQAFPAPKSEPTQQPEKKKI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
10	Phosphorylation	KSRRDRNSWGGFSEK CCCCCCCCCCCCCCC	28.17	25521595
15	Phosphorylation	RNSWGGFSEKSSDWS CCCCCCCCCCCCCCC	47.60	25521595
18	Phosphorylation	WGGFSEKSSDWSSEE CCCCCCCCCCCCCCC	29.49	25521595
19	Phosphorylation	GGFSEKSSDWSSEEE CCCCCCCCCCCCCCC	54.92	25521595
22	Phosphorylation	SEKSSDWSSEEEEPV CCCCCCCCCCCCCCC	32.63	25521595
23	Phosphorylation	EKSSDWSSEEEEPVR CCCCCCCCCCCCCCH	44.78	25521595
31	Ubiquitination	EEEEPVRKAGPVQVL CCCCCCHHCCCEEEE	58.91	27667366
364	Ubiquitination	LAAVATAKDTYNKKM HHHHHHHHHHCHHHH	46.37	22790023
395	Acetylation	QSKHLQLKEESVKLF HHCCHHHHHHHHHHH	46.61	-
395	Ubiquitination	QSKHLQLKEESVKLF HHCCHHHHHHHHHHH	46.61	22790023

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ATLA1_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ATLA1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ATLA1_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of ATLA1_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Solid tumor proteome and phosphoproteome analysis by high resolutionmass spectrometry.";
Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J.,Faessler R., Mann M.;
J. Proteome Res. 7:5314-5326(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-10, AND MASSSPECTROMETRY.
PubMed: 19367708

"Large-scale phosphorylation analysis of mouse liver.";
Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-22 AND SER-23, AND MASSSPECTROMETRY.
PubMed: 17242355

"Proteomic analysis of in vivo phosphorylated synaptic proteins.";
Collins M.O., Yu L., Coba M.P., Husi H., Campuzano I.,Blackstock W.P., Choudhary J.S., Grant S.G.;
J. Biol. Chem. 280:5972-5982(2005).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-18; SER-22 AND SER-23,AND MASS SPECTROMETRY.
PubMed: 15572359