dbPTM

DKKL1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	DKKL1_HUMAN
UniProt AC	Q9UK85
Protein Name	Dickkopf-like protein 1 {ECO:0000305}
Gene Name	DKKL1 {ECO:0000312\|HGNC:HGNC:16528}
Organism	Homo sapiens (Human).
Sequence Length	242
Subcellular Localization	Secreted . Cytoplasmic vesicle, secretory vesicle, acrosome . Localized specifically to the crescent shaped acrosome at the apex of the sperm head.
Protein Description	Involved in fertilization by facilitating sperm penetration of the zona pellucida. May promotes spermatocyte apoptosis, thereby limiting sperm production. In adults, may reduces testosterone synthesis in Leydig cells. Is not essential either for development or fertility..
Protein Sequence	MGEASPPAPARRHLLVLLLLLSTLVIPSAAAPIHDADAQESSLGLTGLQSLLQGFSRLFLKGNLLRGIDSLFSAPMDFRGLPGNYHKEENQEHQLGNNTLSSHLQIDKMTDNKTGEVLISENVVASIQPAEGSFEGDLKVPRMEEKEALVPIQKATDSFHTELHPRVAFWIIKLPRRRSHQDALEGGHWLSEKRHRLQAIRDGLRKGTHKDVLEEGTESSSHSRLSPRKTHLLYILRPSRQL

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
5	Phosphorylation	---MGEASPPAPARR ---CCCCCCCHHHHH	27.41	28122231
97	N-linked_Glycosylation	NQEHQLGNNTLSSHL CCCCCCCCCHHHHHE	47.08	UniProtKB CARBOHYD
110	Phosphorylation	HLQIDKMTDNKTGEV HEEEEECCCCCCCCE	42.01	22210691
112	N-linked_Glycosylation	QIDKMTDNKTGEVLI EEEECCCCCCCCEEE	34.32	UniProtKB CARBOHYD
114	Phosphorylation	DKMTDNKTGEVLISE EECCCCCCCCEEEEC	44.84	22210691
120	Phosphorylation	KTGEVLISENVVASI CCCCEEEECCEEEEE	20.96	22210691
126	Phosphorylation	ISENVVASIQPAEGS EECCEEEEEECCCCC	15.33	22210691
158	Phosphorylation	PIQKATDSFHTELHP EHHHHCCCCCCCCCH	17.99	24719451
223	Phosphorylation	GTESSSHSRLSPRKT CCCCCCCCCCCCCCE	36.54	20068231
226	Phosphorylation	SSSHSRLSPRKTHLL CCCCCCCCCCCEEEE	22.88	21955146
230	Phosphorylation	SRLSPRKTHLLYILR CCCCCCCEEEEEEEC	21.02	27762562
234	Phosphorylation	PRKTHLLYILRPSRQ CCCEEEEEEECCCCC	12.31	25348772
239	Phosphorylation	LLYILRPSRQL---- EEEEECCCCCC----	26.65	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of DKKL1_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of DKKL1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of DKKL1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
FJX1_HUMAN	FJX1	physical	21988832
PCDGB_HUMAN	PCDHGA11	physical	28514442
PEX6_HUMAN	PEX6	physical	28514442
NUCB1_HUMAN	NUCB1	physical	28514442
PCSK1_HUMAN	PCSK1N	physical	28514442
ITIH2_HUMAN	ITIH2	physical	28514442
MGT4B_HUMAN	MGAT4B	physical	28514442
FAT4_HUMAN	FAT4	physical	28514442
RA51B_HUMAN	RAD51B	physical	28514442
XRCC2_HUMAN	XRCC2	physical	28514442
CELR2_HUMAN	CELSR2	physical	28514442
LCHN_HUMAN	KIAA1147	physical	28514442
CANT1_HUMAN	CANT1	physical	28514442
ATS2_HUMAN	ADAMTS2	physical	28514442
ITA8_HUMAN	ITGA8	physical	28514442
RA51D_HUMAN	RAD51D	physical	28514442
CELR3_HUMAN	CELSR3	physical	28514442
DCAM_HUMAN	AMD1	physical	28514442
FREM2_HUMAN	FREM2	physical	28514442
NJMU_HUMAN	C17orf75	physical	28514442
TGBR3_HUMAN	TGFBR3	physical	28514442
LRP5_HUMAN	LRP5	physical	28514442
NLGN2_HUMAN	NLGN2	physical	28514442
HSP13_HUMAN	HSPA13	physical	28514442
CBWD1_HUMAN	CBWD1	physical	28514442
CELR1_HUMAN	CELSR1	physical	28514442
FRAS1_HUMAN	FRAS1	physical	28514442
INT2_HUMAN	INTS2	physical	28514442
AMD_HUMAN	PAM	physical	28514442
ANM9_HUMAN	PRMT9	physical	28514442
BMP7_HUMAN	BMP7	physical	28514442
SYHM_HUMAN	HARS2	physical	28514442
XPR1_HUMAN	XPR1	physical	28514442
MDN1_HUMAN	MDN1	physical	28514442
HS12A_HUMAN	HSPA12A	physical	28514442
FAT3_HUMAN	FAT3	physical	28514442
VWA8_HUMAN	VWA8	physical	28514442
PEX1_HUMAN	PEX1	physical	28514442
PCDH7_HUMAN	PCDH7	physical	28514442
LARG2_HUMAN	GYLTL1B	physical	28514442
DPOD2_HUMAN	POLD2	physical	28514442
ITA7_HUMAN	ITGA7	physical	28514442
CO6A2_HUMAN	COL6A2	physical	28514442
OAF_HUMAN	OAF	physical	28514442
PCD20_HUMAN	PCDH20	physical	28514442
HTRA1_HUMAN	HTRA1	physical	28514442
GT253_HUMAN	CERCAM	physical	28514442
SPAT5_HUMAN	SPATA5	physical	28514442
EFTU_HUMAN	TUFM	physical	28514442
PDPR_HUMAN	PDPR	physical	28514442
KDIS_HUMAN	KIDINS220	physical	28514442
CPSM_HUMAN	CPS1	physical	28514442
CD109_HUMAN	CD109	physical	28514442
TMPPE_HUMAN	TMPPE	physical	28514442
FAT1_HUMAN	FAT1	physical	28514442
RPTOR_HUMAN	RPTOR	physical	28514442
SPA5L_HUMAN	SPATA5L1	physical	28514442
TBC9B_HUMAN	TBC1D9B	physical	28514442
INT12_HUMAN	INTS12	physical	28514442
DPOE1_HUMAN	POLE	physical	28514442
APLP2_HUMAN	APLP2	physical	28514442
XYLK_HUMAN	FAM20B	physical	28514442
GPR98_HUMAN	GPR98	physical	28514442
RA51C_HUMAN	RAD51C	physical	28514442
LTN1_HUMAN	LTN1	physical	28514442
DUSTY_HUMAN	DSTYK	physical	28514442
TBL3_HUMAN	TBL3	physical	28514442
GALT7_HUMAN	GALNT7	physical	28514442
LRP6_HUMAN	LRP6	physical	28514442
NOCT_HUMAN	CCRN4L	physical	28514442
GPD1L_HUMAN	GPD1L	physical	28514442
TBB3_HUMAN	TUBB3	physical	28514442
UGDH_HUMAN	UGDH	physical	28514442

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of DKKL1_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks."; Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.; Cell 127:635-648(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-223 AND SER-226, ANDMASS SPECTROMETRY.	17081983 [Abstract]