| UniProt ID | NRG1_HUMAN | |
|---|---|---|
| UniProt AC | Q02297 | |
| Protein Name | Pro-neuregulin-1, membrane-bound isoform | |
| Gene Name | NRG1 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 640 | |
| Subcellular Localization |
Pro-neuregulin-1, membrane-bound isoform: Cell membrane Single-pass type I membrane protein. Does not seem to be active. Neuregulin-1: Secreted. Isoform 8: Nucleus. May be nuclear. Isoform 9: Secreted. Has a signal peptide. Isoform 10: |
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| Protein Description | Direct ligand for ERBB3 and ERBB4 tyrosine kinase receptors. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. The multiple isoforms perform diverse functions such as inducing growth and differentiation of epithelial, glial, neuronal, and skeletal muscle cells; inducing expression of acetylcholine receptor in synaptic vesicles during the formation of the neuromuscular junction; stimulating lobuloalveolar budding and milk production in the mammary gland and inducing differentiation of mammary tumor cells; stimulating Schwann cell proliferation; implication in the development of the myocardium such as trabeculation of the developing heart. Isoform 10 may play a role in motor and sensory neuron development. Binds to ERBB4. [PubMed: 10867024] | |
| Protein Sequence | MSERKEGRGKGKGKKKERGSGKKPESAAGSQSPALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGMPASTEGAYVSSESPIRISVSTEGANTSSSTSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCQPGFTGARCTENVPMKVQNQEKAEELYQKRVLTITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREAETSFSTSHYTSTAHHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHSSPTGGPRGRLNGTGGPRECNSFLRHARETPDSYRDSPHSERYVSAMTTPARMSPVDFHTPSSPKSPPSEMSPPVSSMTVSMPSMAVSPFMEEERPLLLVTPPRLREKKFDHHPQQFSSFHHNPAHDSNSLPASPLRIVEDEEYETTQEYEPAQEPVKKLANSRRAKRTKPNGHIANRLEVDSNTSSQSSNSESETEDERVGEDTPFLGIQNPLAASLEATPAFRLADSRTNPAGRFSTQEEIQARLSSVIANQDPIAV | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 10 | Acetylation | ERKEGRGKGKGKKKE CCCCCCCCCCCCCCC | 56.97 | 70789 | |
| 11 (in isoform 11) | Phosphorylation | - | 46.93 | 27174698 | |
| 12 | Acetylation | KEGRGKGKGKKKERG CCCCCCCCCCCCCCC | 71.67 | 133343 | |
| 12 (in isoform 11) | Phosphorylation | - | 71.67 | 27174698 | |
| 15 | Acetylation | RGKGKGKKKERGSGK CCCCCCCCCCCCCCC | 69.41 | 70797 | |
| 16 | Acetylation | GKGKGKKKERGSGKK CCCCCCCCCCCCCCC | 57.01 | 70793 | |
| 26 | Phosphorylation | GSGKKPESAAGSQSP CCCCCCCCCCCCCCC | 31.76 | 28176443 | |
| 30 | Phosphorylation | KPESAAGSQSPALPP CCCCCCCCCCCCCCH | 23.82 | 28176443 | |
| 32 | Phosphorylation | ESAAGSQSPALPPRL CCCCCCCCCCCCHHH | 17.53 | 28176443 | |
| 43 | Acetylation | PPRLKEMKSQESAAG CHHHHHHHCCCCCCC | 50.51 | 20167786 | |
| 120 | N-linked_Glycosylation | KVISKLGNDSASANI HHHHHHCCCCCCCCE | 50.96 | UniProtKB CARBOHYD | |
| 126 | N-linked_Glycosylation | GNDSASANITIVESN CCCCCCCCEEEEECC | 29.46 | UniProtKB CARBOHYD | |
| 149 | Phosphorylation | STEGAYVSSESPIRI CCCCEEECCCCCEEE | 18.73 | 28348404 | |
| 150 | Phosphorylation | TEGAYVSSESPIRIS CCCEEECCCCCEEEE | 31.86 | 28348404 | |
| 152 | Phosphorylation | GAYVSSESPIRISVS CEEECCCCCEEEEEE | 27.81 | 28348404 | |
| 157 | O-linked_Glycosylation | SESPIRISVSTEGAN CCCCEEEEEECCCCC | 10.52 | 30620550 | |
| 164 | N-linked_Glycosylation | SVSTEGANTSSSTST EEECCCCCCCCCCCC | 51.88 | UniProtKB CARBOHYD | |
| 169 | Phosphorylation | GANTSSSTSTSTTGT CCCCCCCCCCCCCCC | 37.66 | - | |
| 170 | Phosphorylation | ANTSSSTSTSTTGTS CCCCCCCCCCCCCCC | 23.47 | - | |
| 177 | Phosphorylation | STSTTGTSHLVKCAE CCCCCCCCHHEEECC | 19.03 | - | |
| 203 (in isoform 9) | Phosphorylation | - | 57.75 | - | |
| 232 (in isoform 9) | Phosphorylation | - | 36.15 | 22210691 | |
| 281 | Phosphorylation | LHDRLRQSLRSERNN HHHHHHHHHHHHHHC | 21.22 | 29496963 | |
| 284 | Phosphorylation | RLRQSLRSERNNMMN HHHHHHHHHHHCCCC | 46.32 | 29449344 | |
| 319 | Phosphorylation | YVSKNVISSEHIVER HHHCCCCCCCHHHHH | 25.95 | 28348404 | |
| 320 | Phosphorylation | VSKNVISSEHIVERE HHCCCCCCCHHHHHH | 23.28 | 28348404 | |
| 382 | Phosphorylation | SVENSRHSSPTGGPR CCCCCCCCCCCCCCC | 36.58 | 24706070 | |
| 383 | Phosphorylation | VENSRHSSPTGGPRG CCCCCCCCCCCCCCC | 21.98 | 28102081 | |
| 385 | Phosphorylation | NSRHSSPTGGPRGRL CCCCCCCCCCCCCCC | 57.63 | 28102081 | |
| 395 | Phosphorylation | PRGRLNGTGGPRECN CCCCCCCCCCCHHHH | 37.58 | - | |
| 403 | Phosphorylation | GGPRECNSFLRHARE CCCHHHHHHHHHHHC | 37.00 | 22617229 | |
| 414 | Phosphorylation | HARETPDSYRDSPHS HHHCCCCHHCCCCCC | 24.22 | - | |
| 415 | Phosphorylation | ARETPDSYRDSPHSE HHCCCCHHCCCCCCH | 26.31 | - | |
| 418 | Phosphorylation | TPDSYRDSPHSERYV CCCHHCCCCCCHHHH | 18.60 | 28348404 | |
| 424 | Phosphorylation | DSPHSERYVSAMTTP CCCCCHHHHHHCCCC | 8.49 | 23090842 | |
| 426 | Phosphorylation | PHSERYVSAMTTPAR CCCHHHHHHCCCCCC | 11.91 | 27422710 | |
| 429 | Phosphorylation | ERYVSAMTTPARMSP HHHHHHCCCCCCCCC | 29.37 | 27422710 | |
| 430 | Phosphorylation | RYVSAMTTPARMSPV HHHHHCCCCCCCCCC | 11.23 | 23090842 | |
| 435 | Phosphorylation | MTTPARMSPVDFHTP CCCCCCCCCCCCCCC | 19.07 | 30266825 | |
| 441 | Phosphorylation | MSPVDFHTPSSPKSP CCCCCCCCCCCCCCC | 25.51 | 30266825 | |
| 443 | Phosphorylation | PVDFHTPSSPKSPPS CCCCCCCCCCCCCCH | 61.50 | 23090842 | |
| 444 | Phosphorylation | VDFHTPSSPKSPPSE CCCCCCCCCCCCCHH | 37.23 | 27422710 | |
| 452 (in isoform 3) | Phosphorylation | - | 9.52 | 28348404 | |
| 453 (in isoform 3) | Phosphorylation | - | 23.23 | 28348404 | |
| 454 (in isoform 3) | Phosphorylation | - | 31.81 | 28348404 | |
| 482 | Phosphorylation | ERPLLLVTPPRLREK CCCEEEECCCCCCCC | 27.78 | 28348404 | |
| 511 | Phosphorylation | NPAHDSNSLPASPLR CCCCCCCCCCCCCCE | 39.42 | 27422710 | |
| 525 | Phosphorylation | RIVEDEEYETTQEYE EEECCCCCCCCCCCC | 19.27 | - | |
| 528 | Phosphorylation | EDEEYETTQEYEPAQ CCCCCCCCCCCCCCH | 13.89 | 18077418 | |
| 531 | Phosphorylation | EYETTQEYEPAQEPV CCCCCCCCCCCHHHH | 19.86 | - | |
| 551 | Acetylation | SRRAKRTKPNGHIAN CCCHHCCCCCCCCCC | 40.28 | 7711269 | |
| 619 | Phosphorylation | TNPAGRFSTQEEIQA CCCCCCCCCHHHHHH | 28.02 | 27422710 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of NRG1_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of NRG1_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of NRG1_HUMAN !! | ||||||
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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