TM181_HUMAN - dbPTM
TM181_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID TM181_HUMAN
UniProt AC Q9P2C4
Protein Name Transmembrane protein 181
Gene Name TMEM181
Organism Homo sapiens (Human).
Sequence Length 612
Subcellular Localization Membrane
Multi-pass membrane protein .
Protein Description Mediates action of cytolethal distending toxins (CDT), which are secreted by many pathogenic bacteria. Expression level of TMEM181 is rate-limiting for intoxication..
Protein Sequence MGAAPSPTQASSRGGGPGPPAPTRAVSSSSRARGGALSALGPSPARPLTTSPAPAPPPRSRPARQQPDPQCWEKRGGAGGDTKGGAAGPGPGRLRGMDAEYPAFEPPLCSELKHLCRRLREAYRELKEDLTPFKDDRYYRLAPMRLYTLSKRHFVLVFVVFFICFGLTIFVGIRGPKVIQTSAANFSLNNSKKLKPIQILSNPLSTYNQQLWLTCVVELDQSKETSIKTSFPMTVKVDGVAQDGTTMYIHNKVHNRTRTLTCAGKCAEIIVAHLGYLNYTQYTVIVGFEHLKLPIKGMNFTWKTYNPAFSRLEIWFRFFFVVLTFIVTCLFAHSLRKFSMRDWGIEQKWMSVLLPLLLLYNDPFFPLSFLVNSWLPGMLDDLFQSMFLCALLLFWLCVYHGIRVQGERKCLTFYLPKFFIVGLLWLASVTLGIWQTVNELHDPMYQYRVDTGNFQGMKVFFMVVAAVYILYLLFLIVRACSELRHMPYVDLRLKFLTALTFVVLVISIAILYLRFGAQVLQDNFVAELSTHYQNSAEFLSFYGLLNFYLYTLAFVYSPSKNALYESQLKDNPAFSMLNDSDDDVIYGSDYEEMPLQNGQAIRAKYKEESDSD
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
29PhosphorylationPTRAVSSSSRARGGA
CCCCCCCCCCCCCCC		19.1424719451
43PhosphorylationALSALGPSPARPLTT
CCCCCCCCCCCCCCC		29.4128787133
51PhosphorylationPARPLTTSPAPAPPP
CCCCCCCCCCCCCCC		17.5220068231
60PhosphorylationAPAPPPRSRPARQQP
CCCCCCCCCCCHHCC		48.6820068231
131PhosphorylationRELKEDLTPFKDDRY
HHHHHCCCCCCCCCC		38.7124117733
181PhosphorylationRGPKVIQTSAANFSL
CCCHHHCCCCCCCCC		14.8120068231
182PhosphorylationGPKVIQTSAANFSLN
CCHHHCCCCCCCCCC		14.7020068231
187PhosphorylationQTSAANFSLNNSKKL
CCCCCCCCCCCCCCC		29.9620068231
191PhosphorylationANFSLNNSKKLKPIQ
CCCCCCCCCCCCCEE		30.0520068231
228UbiquitinationQSKETSIKTSFPMTV
CCCCCCCEEECCEEE		37.5729967540
229PhosphorylationSKETSIKTSFPMTVK
CCCCCCEEECCEEEE		33.65-
230PhosphorylationKETSIKTSFPMTVKV
CCCCCEEECCEEEEE		23.50-
445PhosphorylationNELHDPMYQYRVDTG
HHHCCCCEEEEECCC		14.0526074081
447PhosphorylationLHDPMYQYRVDTGNF
HCCCCEEEEECCCCC		8.6326074081
451PhosphorylationMYQYRVDTGNFQGMK
CEEEEECCCCCCHHH		31.0326074081
468PhosphorylationFMVVAAVYILYLLFL
HHHHHHHHHHHHHHH		4.7726074081
471PhosphorylationVAAVYILYLLFLIVR
HHHHHHHHHHHHHHH		7.5626074081
481PhosphorylationFLIVRACSELRHMPY
HHHHHHHHHHCCCCC		38.39-
564PhosphorylationSPSKNALYESQLKDN
CCCCCCCHHHHCCCC		15.8921945579
566PhosphorylationSKNALYESQLKDNPA
CCCCCHHHHCCCCCC		27.5320363803
569UbiquitinationALYESQLKDNPAFSM
CCHHHHCCCCCCHHH		48.07-
575PhosphorylationLKDNPAFSMLNDSDD
CCCCCCHHHCCCCCC		25.1922199227
580PhosphorylationAFSMLNDSDDDVIYG
CHHHCCCCCCCEEEC		41.6925159151
586PhosphorylationDSDDDVIYGSDYEEM
CCCCCEEECCCCCCC		15.4922199227
588PhosphorylationDDDVIYGSDYEEMPL
CCCEEECCCCCCCCC		21.7620363803
590PhosphorylationDVIYGSDYEEMPLQN
CEEECCCCCCCCCCC		18.5822199227
605PhosphorylationGQAIRAKYKEESDSD
CHHHHHHHHHHCCCC		23.7326552605
609PhosphorylationRAKYKEESDSD----
HHHHHHHCCCC----		43.4320363803
611PhosphorylationKYKEESDSD------
HHHHHCCCC------		55.2720363803
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of TM181_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of TM181_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of TM181_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of TM181_HUMAN !!
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of TM181_HUMAN

loading...

Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks.";
Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.;
Cell 127:635-648(2006).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-580, AND MASSSPECTROMETRY.

TOP
© 2024 Institute of Bioinformatics and Systems Biology, NYCU | Designed by : BiOmics Laboratory