INSR_CAEEL - dbPTM
INSR_CAEEL - PTM Information in dbPTM
Basic Information of Protein
UniProt ID INSR_CAEEL
UniProt AC Q968Y9
Protein Name Insulin-like receptor {ECO:0000250|UniProtKB:P06213}
Gene Name daf-2 {ECO:0000312|WormBase:Y55D5A.5a}
Organism Caenorhabditis elegans.
Sequence Length 1846
Subcellular Localization Membrane
Single-pass type I membrane protein .
Protein Description Insulin receptor-like tyrosine kinase which regulates metabolism, controls longevity and prevents developmental arrest at the dauer stage. [PubMed: 9252323]
Protein Sequence MTRMNIVRCRRRHKILENLEEENLGPSCSSTTSTTAATEALGTTTEDMRLKQQRSSSRATEHDIVDGNHHDDEHITMRRLRLVKNSRTRRRTTPDSSMDCYEENPPSQKTSINYSWISKKSSMTSLMLLLLFAFVQPCASIVEKRCGPIDIRNRPWDIKPQWSKLGDPNEKDLAGQRMVNCTVVEGSLTISFVLKHKTKAQEEMHRSLQPRYSQDEFITFPHLREITGTLLVFETEGLVDLRKIFPNLRVIGGRSLIQHYALIIYRNPDLEIGLDKLSVIRNGGVRIIDNRKLCYTKTIDWKHLITSSINDVVVDNAAEYAVTETGLMCPRGACEEDKGESKCHYLEEKNQEQGVERVQSCWSNTTCQKSCAYDRLLPTKEIGPGCDANGDRCHDQCVGGCERVNDATACHACKNVYHKGKCIEKCDAHLYLLLQRRCVTREQCLQLNPVLSNKTVPIKATAGLCSDKCPDGYQINPDDHRECRKCVGKCEIVCEINHVIDTFPKAQAIRLCNIIDGNLTIEIRGKQDSGMASELKDIFANIHTITGYLLVRQSSPFISLNMFRNLRRIEAKSLFRNLYAITVFENPNLKKLFDSTTDLTLDRGTVSIANNKMLCFKYIKQLMSKLNIPLDPIDQSEGTNGEKAICEDMAINVSITAVNADSVFFSWPSFNITDIDQRKFLGYELFFKEVPRIDENMTIEEDRSACVDSWQSVFKQYYETSNGEPTPDIFMDIGPRERIRPNTLYAYYVATQMVLHAGAKNGVSKIGFVRTSYYTPDPPTLALAQVDSDAIHITWEAPLQPNGDLTHYTIMWRENEVSPYEEAEKFCTDASTPANRQHTKDPKETIVADKPVDIPSSRTVAPTLLTMMGHEDQQKTCAATPGCCSCSAIEESSEQNKKKRPDPMSAIESSAFENKLLDEVLMPRDTMRVRRSIEDANRVSEELEKAENLGKAPKTLGGKKPLIHISKKKPSSSSTTSTPAPTIASMYALTRKPTTVPGTRIRLYEIYEPLPGSWAINVSALALDNSYVIRNLKHYTLYAISLSACQNMTVPGASCSISHRAGALKRTKHITDIDKVLNETIEWRFMNNSQQVNVTWDPPTEVNGGIFGYVVKLKSKVDGSIVMTRCVGAKRGYSTRNQGVLFQNLADGRYFVSVTATSVHGAGPEAESSDPIVVMTPGFFTVEIILGMLLVFLILMSIAGCIIYYYIQVRYGKKVKALSDFMQLNPEYCVDNKYNADDWELRQDDVVLGQQCGEGSFGKVYLGTGNNVVSLMGDRFGPCAIKINVDDPASTENLNYLMEANIMKNFKTNFIVKLYGVISTVQPAMVVMEMMDLGNLRDYLRSKREDEVFNETDCNFFDIIPRDKFHEWAAQICDGMAYLESLKFCHRDLAARNCMINRDETVKIGDFGMARDLFYHDYYKPSGKRMMPVRWMSPESLKDGKFDSKSDVWSFGVVLYEMVTLGAQPYIGLSNDEVLNYIGMARKVIKKPECCENYWYKVMKMCWRYSPRDRPTFLQLVHLLAAEASPEFRDLSFVLTDNQMILDDSEALDLDDIDDTDMNDQVVEVAPDVENVEVQSDSERRNTDSIPLKQFKTIPPINATTSHSTISIDETPMKAKQREGSLDEEYALMNHSGGPSDAEVRTYAGDGDYVERDVRENDVPTRRNTGASTSSYTGGGPYCLTNRGGSNERGAGFGEAVRLTDGVGSGHLNDDDYVEKEISSMDTRRSTGASSSSYGVPQTNWSGNRGATYYTSKAQQAATAAAAAAAALQQQQNGGRGDRLTQLPGTGHLQSTRGGQDGDYIETEPKNYRNNGSPSRNGNSRDIFNGRSAFGENEHLIEDNEHHPLV
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
113N-linked_GlycosylationPSQKTSINYSWISKK
CCCCCEECHHHHCCC		25.26-
180N-linked_GlycosylationLAGQRMVNCTVVEGS
CCCCCCEEEEEEECE		13.34-
364N-linked_GlycosylationRVQSCWSNTTCQKSC
HHHHHHCCCHHHHHC		18.2017761667
453N-linked_GlycosylationQLNPVLSNKTVPIKA
HHCCCCCCCCCCEEE		39.6017761667
518N-linked_GlycosylationLCNIIDGNLTIEIRG
HHCEECCCEEEEEEC		30.20-
652N-linked_GlycosylationICEDMAINVSITAVN
EECCCEEEEEEEEEC		16.37-
671N-linked_GlycosylationFFSWPSFNITDIDQR
EECCCCCCCCCCHHH		40.36-
696N-linked_GlycosylationEVPRIDENMTIEEDR
ECCCCCCCCCCCCHH		29.2017761667
966PhosphorylationKKPLIHISKKKPSSS
CCCEEEEECCCCCCC		25.0228854356
1017N-linked_GlycosylationLPGSWAINVSALALD
CCCCEEEEEEEEEEC		17.5917761667
1047N-linked_GlycosylationISLSACQNMTVPGAS
EEHHHHCCCCCCCCC		28.16-
1078N-linked_GlycosylationTDIDKVLNETIEWRF
CHHHHHHHHHEEEEC		47.5617761667
1087N-linked_GlycosylationTIEWRFMNNSQQVNV
HEEEECCCCCCCEEE		42.14-
1093N-linked_GlycosylationMNNSQQVNVTWDPPT
CCCCCCEEEEECCCC		22.59-
1418PhosphorylationRDLFYHDYYKPSGKR
CHHHCCCCCCCCCCC		10.4827067626
1419PhosphorylationDLFYHDYYKPSGKRM
HHHCCCCCCCCCCCC		23.6027067626
1583PhosphorylationSDSERRNTDSIPLKQ
CCCCCCCCCCCCHHH		29.3419530675
1585PhosphorylationSERRNTDSIPLKQFK
CCCCCCCCCCHHHCC		24.8619530675
1621PhosphorylationKAKQREGSLDEEYAL
CCCCCCCCCCHHHHH		28.0919530675
1626PhosphorylationEGSLDEEYALMNHSG
CCCCCHHHHHHCCCC		11.7319530675
1649PhosphorylationTYAGDGDYVERDVRE
HCCCCCCEEECCCCC		15.1127067626
1713PhosphorylationGHLNDDDYVEKEISS
CCCCCHHHHHHHHHC		19.9427067626
1800PhosphorylationRGGQDGDYIETEPKN
CCCCCCCCEECCCCC		13.2427067626
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of INSR_CAEEL !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of INSR_CAEEL !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of INSR_CAEEL !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
BAR1_CAEELbar-1genetic
15905404
POT1_CAEELpot-1genetic
17897480
UTP18_CAEELB0280.9genetic
17897480
CDK12_CAEELcdtl-7genetic
17897480
PISD_CAEELpsd-1genetic
17897480
YMP9_CAEELB0361.9genetic
17897480
RSSA_CAEELrps-0genetic
17897480
CPB3_CAEELcpb-3genetic
17897480
RIR2_CAEELrnr-2genetic
17897480
DHX16_CAEELmog-4genetic
17897480
TCPE_CAEELcct-5genetic
17897480
CGH1_CAEELcgh-1genetic
17897480
ROCK_CAEELlet-502genetic
17897480
PDI1_CAEELpdi-1genetic
17897480
SEM5_CAEELsem-5genetic
17897480
UTP11_CAEELC16C10.2genetic
17897480
NSRP1_CAEELccdc-55genetic
17897480
RPB2_CAEELrpb-2genetic
17897480
PCID2_CAEELC27F2.10genetic
17897480
LAG3_CAEELsel-8genetic
17897480
PPH6_CAEELpph-6genetic
17897480
ATPB_CAEELatp-2genetic
17897480
SUMV1_CAEELsumv-1genetic
17897480
TBB2_CAEELtbb-2genetic
17897480
CCNE_CAEELcye-1genetic
17897480
PAL1_CAEELpal-1genetic
17897480
YQI9_CAEELC45G9.9genetic
17897480
SOP2_CAEELsop-2genetic
17897480
LAM2_CAEELlam-2genetic
17897480
BAR1_CAEELbar-1genetic
17897480
BTF3_CAEELicd-1genetic
17897480
MOG5_CAEELmog-5genetic
17897480
MLE_CAEELmlc-3genetic
17897480
RL3_CAEELrpl-3genetic
17897480
TBX2_CAEELtbx-2genetic
17897480
ZYG9_CAEELzyg-9genetic
17897480
RPAB3_CAEELrpb-8genetic
17897480
LRP_CAEELlrp-1genetic
17897480
SPD2_CAEELspd-2genetic
17897480
ITPR_CAEELitr-1genetic
17897480
WDR48_CAEELF35G12.4genetic
17897480
MAB21_CAEELmab-21genetic
17897480
RS21_CAEELrps-21genetic
17897480
RS14_CAEELrps-14genetic
17897480
PHA4_CAEELpha-4genetic
17897480
MOM2_CAEELmom-2genetic
17897480
DPY7_CAEELdpy-7genetic
17897480
MED12_CAEELdpy-22genetic
17897480
HMG12_CAEELhmg-1.2genetic
17897480
SORF2_CAEELF52C9.1genetic
17897480
EMB30_CAEELemb-30genetic
17897480
UCR1_CAEELucr-1genetic
17897480
MEI2_CAEELmei-2genetic
17897480
EGL15_CAEELegl-15genetic
17897480
DCN1_CAEELdcn-1genetic
17897480
HMP2_CAEELhmp-2genetic
17897480
MPIP1_CAEELcdc-25.1genetic
17897480
MUP4_CAEELmup-4genetic
17897480
EPI1_CAEELepi-1genetic
17897480
MUA3_CAEELmua-3genetic
17897480
YRJ5_CAEELK10D2.5genetic
17897480
SUMO_CAEELsmo-1genetic
17897480
LIAS_CAEELM01F1.3genetic
17897480
14331_CAEELpar-5genetic
17897480
UN119_CAEELunc-119genetic
17897480
PAN1_CAEELpan-1genetic
17897480
VMA21_CAEELpdcd-2genetic
17897480
MCM5_CAEELmcm-5genetic
17897480
PCF11_CAEELpcf-11genetic
17897480
MED11_CAEELmdt-11genetic
17897480
RL6_CAEELrpl-6genetic
17897480
SPT6H_CAEELemb-5genetic
17897480
CKI1_CAEELcki-1genetic
17897480
GARS_CAEELgars-1genetic
17897480
SENP_CAEELulp-1genetic
17897480
DAF9_CAEELdaf-9genetic
17897480
TTC27_CAEELtrd-1genetic
17897480
TBP_CAEELtbp-1genetic
17897480
YO95_CAEELT20B12.5genetic
17897480
WBS14_CAEELmml-1genetic
17897480
DRE2_CAEELT20B12.7genetic
17897480
SSP1A_CAEELhmg-4genetic
17897480
LGC50_CAEELlgc-50genetic
17897480
NDUS8_CAEELT20H4.5genetic
17897480
GLD1_CAEELgld-1genetic
17897480
PAR6_CAEELpar-6genetic
17897480
POP1_CAEELpop-1genetic
17897480
GSK3_CAEELgsk-3genetic
17897480
CHK1_CAEELchk-1genetic
17897480
VPS28_CAEELvps-28genetic
17897480
UNC52_CAEELunc-52genetic
17897480
SMA2_CAEELsma-2genetic
17897480
NHR9_CAEELnhr-9genetic
17897480
YWIE_CAEELZK546.14genetic
17897480
PAT3_CAEELpat-3genetic
17897480
LIN2_CAEELlin-2physical
22672310
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of INSR_CAEEL

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Related Literatures of Post-Translational Modification
N-linked Glycosylation
ReferencePubMed
"Proteomics reveals N-linked glycoprotein diversity in Caenorhabditiselegans and suggests an atypical translocation mechanism for integralmembrane proteins.";
Kaji H., Kamiie J., Kawakami H., Kido K., Yamauchi Y., Shinkawa T.,Taoka M., Takahashi N., Isobe T.;
Mol. Cell. Proteomics 6:2100-2109(2007).
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-364; ASN-453; ASN-696;ASN-1017 AND ASN-1078, AND MASS SPECTROMETRY.

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