ZYG9_CAEEL - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ZYG9_CAEEL
• UniProt AC: G5EEM5
• Protein Name: Zygote defective protein 9 {ECO:0000303|PubMed:9606208}
• Gene Name: zyg-9 {ECO:0000312|EMBL:AAC17865.1, ECO:0000312|WormBase:F22B5.7}
• Organism: Caenorhabditis elegans.
• Sequence Length: 1415
• Subcellular Localization: Cytoplasm, cytoskeleton, spindle pole . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Cytoplasm . Cycles between cytoplasm and centrosome during mitosis in a cell cycle- dependent manner. Centrosomal recruitment requires tbg-1.
• Protein Description: Plays a major role in organizing microtubules and spindle poles during mitosis and meiosis in one-cell stage embryos. Required for default nucleus positioning in oocytes..
• Protein Sequence: MSNWDYLDEVDILPKLPPNFDELRESKKWQERKEALEALLKVLTDNERLSTKASYAELIGHLQMVLAKDANINCQALAAKCIGKFATGLRAKFSSFAGPLLPVIFEKMKEKKPMLREPLVDCSNEVGRTMQSLETGQEDILAALAKPNPQIKQQTALFVARQLDLVVPAKQPKGFIKAVVPVFGKLTGDADQDVREASLQGLGAVQRIIGDKNVKNLLGDASSDEGKMKKIGEYAEKSTASFAEEQAKNAPPVAPTSSTPSASAASGDPSGGTATAVVSSGAPVAEADPWDFLDAFDVLSKMPDGFDTNIESKKWQERKEALEGLLQLITANPKLDPKANYGALVERLQKVLEKDANINVAALAANCITGIANGLRTKFQPFAVSVTPIIFEKFKEKKPTLRDPLVACIDAVVATTNLEAVGEIVLAALGKPNPSIKTQTDLFLQRCFMKLNSQTMPKKTLKTLIPSLIKHSGDSDSEVREASYAAMGAMMRAIGEKPSLQLLADIASDNLKMSKIKEFHQKALDEAGPAEIAEMVKSIHKADAPPAAAPPKKTAPPKKQPEDEEVVEEEDEPLKPPPGDKKKKVPVKENEENEPPVVAPKAELLLSDNEDKKQRIKEEKQLKLVKWNFQAPTDEHISQLQTLLGNQAKVSLMSQLFHKDFKQHLAALDSLVRLADTSPRSLLSNSDLLLKWCTLRFFETNPAALIKVLELCKVIVELIRDTETPMSQEEVSAFVPYLLLKTGEAKDNMRTSVRDIVNVLSDVVGPLKMTPMLLDALKSKNARQRSECLLVIEYYITNAGISPLKSLSVEKTVAPFVGDKDVNVRNAAINVLVACFKFEGDQMWKAAGRMADKDKSLVEERIKRTGVKPGSGVVTSPPTGGPKILVPQQQGSVVRRPASRSRTREPEPEEVQSDTFTIRQDTMPPKTSSRYALRDDVFSSAMGRLDGTQVITPPQPVNGWSNNTFQMKRTNSSSSISSIDTSDQIQRSINNISSSLADVAQDAMFQVTYVLNQPEQRHLVDRRADLVFRASAAQLDLVIEEFNAGRDVSGTMDACTQMLFILMGGVETEHGLEPLNASPDTVKAIISSVLRCIIQIGNTESGYGMARSLNRLAMRLIYRVELSNLLCGLILAMTESLQMNTGITELVSKLSSKWCDELEKRRAQLRASDIVDSFNAFYVCALTELKMDISDSHILIVDNYLERVILQQGDVVLDAARRLSRPHMHLTSMINKILQMMRERKIDPIMPGTLEARMPQEDEAVVVRSGVQVSIDNILRDTSMAVKHIEQLNILIASSDRSWNEYMEYLKNNPMGELIKELVGECSRKKRIDFNLSHVVKSSMAVFKAMAATGPVQEEGRITPTDINRMDTMIVGTPLSRGDATITRARGNMIRPKRTTLSRDQMANIRHTLDRVKNH

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
876	Phosphorylation	PGSGVVTSPPTGGPK CCCCCCCCCCCCCCC	19.78	21082442
892	Phosphorylation	LVPQQQGSVVRRPAS ECCCCCCCEECCCCC	17.07	30078680
899	Phosphorylation	SVVRRPASRSRTREP CEECCCCCCCCCCCC	33.21	19530675
901	Phosphorylation	VRRPASRSRTREPEP ECCCCCCCCCCCCCC	35.19	19530675
970	Phosphorylation	NTFQMKRTNSSSSIS CCEEEEECCCCCCCC	33.65	28854356
972	Phosphorylation	FQMKRTNSSSSISSI EEEEECCCCCCCCCC	30.86	28854356
973	Phosphorylation	QMKRTNSSSSISSID EEEECCCCCCCCCCC	30.12	19060867
974	Phosphorylation	MKRTNSSSSISSIDT EEECCCCCCCCCCCC	31.35	28854356
975	Phosphorylation	KRTNSSSSISSIDTS EECCCCCCCCCCCCH	28.56	30078680
977	Phosphorylation	TNSSSSISSIDTSDQ CCCCCCCCCCCCHHH	24.16	30078680
978	Phosphorylation	NSSSSISSIDTSDQI CCCCCCCCCCCHHHH	23.86	30078680
981	Phosphorylation	SSISSIDTSDQIQRS CCCCCCCCHHHHHHH	32.31	30078680
982	Phosphorylation	SISSIDTSDQIQRSI CCCCCCCHHHHHHHH	24.62	30078680
1349	Phosphorylation	VFKAMAATGPVQEEG HHHHHHCCCCCCCCC	32.26	19530675
1359	Phosphorylation	VQEEGRITPTDINRM CCCCCCCCCCCHHCC	20.83	28854356
1361	Phosphorylation	EEGRITPTDINRMDT CCCCCCCCCHHCCCE	40.64	19060867

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ZYG9_CAEEL !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ZYG9_CAEEL !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ZYG9_CAEEL !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
NHR6_CAEEL	nhr-6	physical	14704431

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.