SPT6H_CAEEL - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SPT6H_CAEEL
• UniProt AC: P34703
• Protein Name: Suppressor of Ty 6 homolog
• Gene Name: emb-5
• Organism: Caenorhabditis elegans.
• Sequence Length: 1521
• Subcellular Localization: Nucleus .
• Protein Description: May regulate transcriptional elongation by RNA polymerase II. Required for several aspects of morphogenesis of C.elegans, including regulation of division in the germline and gut and specification of ventral-uterine precursor cell fate..
• Protein Sequence: MDFIDNQAEESDASSGHSDDEEPQSKKMKMAKEKSKRKKKMVASSDEDEDDDDDEEENRKEMQGFIADDDDEEEDAKSEKSEKSRHSGEDELDDEDLDLINENYDIRETKKQNRVQLGDSSDEDEPIRRPNHEDDDLLSERGSDDGDRRKDRGRGDRGGYGSESERSEDDFIEDDGDAPRRHRKRHRGDENLPEGAEDDARDVFGVEDFNLDEFYDDDDGEDGLEDEEEEIIEDDGEGGEIKIRRKKDTTKKSTLLESIEPSEIDRGFLLPGDKKIAKEDLPERFQLRRTPVTEADDDELESEALWIIKYAFEEGTVTNQADLDQDDKLDCIMNLDPSVYEDRKKAVIKSIKKVLQFIRVRSNSFEPTFIGFYRKEDIDNLLTMNNLWRVYDFDEKWCHLSEKKNKIYDLMRRMREYQELSDDLTAKRRPISDADLMDTKYAETLEQLTDIHANFQLLYGALLDDMIRWEKGRLTGEEEEQEYRVKFKSSIRNDKYQMCVENGIGELAGRFGLTAKQFSENLNWKKHDIEQDPMLPLEAAEEYVCPAFSDSDMVLNGAKFMLAKEISRQPQVRHSVRQEFRQSAHFWIKPTKKGRDTIDQTHPLYDKRYIKSKPVRSLTAEEFLFYHKAKEDGLVDVLIMYESEEDQDSNNYLVNKYLSDSIFQKDEYTENVEQWNSVRDECVNMAITEMLVPYMRDELYNTILEEAKTAVAKKCRKEFASRISRSGYLPDFDNNDDDDDGMDQHGARRIMAVCYPTERDEASFGVMVDENGAIVDYLRMVHFTKRTFGGGNNGLRKAESMDLFKKFVQRRKPHAIGLNIEDMECTRLKRDLEEAVADLFSQNLIYKPIPVFLMDNEAAKVYMRSNVSLAENPDHPPTLRQALSLARLLLDPIPEYAHLWNIDEDIFCLSLHPLQRDIDQEQLALVLSHELVNKVNEEGVDINKCAEFPHYTNMLQFTCGLGPRKATDLLKSIKANDNLIESRSKLVVGCKLGPKVFMNCAGFIKIDTIKVSEKTDAYVEVLDGSRVHPETYEWARKMAVDALEVDDSADPTAALQEIMESPDRLRDLDLDAFADELSRQGFGEKKSTLYDISSELSARYKDLRQPFQEPTGELLYDLLARSGKEIREGAKVLGTVQSVQYRKVDKDAADSMLPDVGEDGLFTCPCCKSFTSSAPGGIQEHMLGDSRQGGCPGTPVGIRVRFDNGMTGFCPNKNISSSHVDNPLTRVKINQPYYFKVLKLDKERFSLFLSCKSSDLKEDDLSQRDQYWDEHQYQADLELMKSESKKKTEANTRVKRVIAHPNFHNVSYEAATKMLDEMDWSECIIRPSANKDSGLSVTWKICDRVYHNFFVKESAKDQVFSIGRQLSVGGEDFEDLDELIARFVQPMIQISHEITTHKYFFPNGTCEETEAVEQFVREKKRELGRSPYVFSASYRQPCQFCISYMFDNTERIRHEYFKIVPHGVRFRHQNFDTLDRMMAWFKRHFHEPPIELRRSAIPAPQYRVGAPPAAPYYPPQFVGYH

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
44	Phosphorylation	RKKKMVASSDEDEDD HHHHHCCCCCCCCCC	27.23	30078680
45	Phosphorylation	KKKMVASSDEDEDDD HHHHCCCCCCCCCCC	34.97	30078680
78	Phosphorylation	DEEEDAKSEKSEKSR CHHHHHHHHHHHHHC	52.56	26392051
81	Phosphorylation	EDAKSEKSEKSRHSG HHHHHHHHHHHCCCC	46.32	26392051
84	Phosphorylation	KSEKSEKSRHSGEDE HHHHHHHHCCCCCCC	31.04	26392051
87	Phosphorylation	KSEKSRHSGEDELDD HHHHHCCCCCCCCCH	42.65	26392051
120	Phosphorylation	NRVQLGDSSDEDEPI CCCCCCCCCCCCCCC	37.58	19060867
121	Phosphorylation	RVQLGDSSDEDEPIR CCCCCCCCCCCCCCC	50.16	19060867
139	Phosphorylation	HEDDDLLSERGSDDG CCCCHHHHHCCCCCC	32.32	30078680
143	Phosphorylation	DLLSERGSDDGDRRK HHHHHCCCCCCCCCC	38.46	30078680
160	Phosphorylation	GRGDRGGYGSESERS CCCCCCCCCCCCCCC	21.94	30078680
162	Phosphorylation	GDRGGYGSESERSED CCCCCCCCCCCCCCC	29.48	19060867
164	Phosphorylation	RGGYGSESERSEDDF CCCCCCCCCCCCCCC	39.75	19060867
167	Phosphorylation	YGSESERSEDDFIED CCCCCCCCCCCCCCC	41.13	19060867
475	Phosphorylation	RWEKGRLTGEEEEQE HHHCCCCCCCHHHHH	40.98	26392051

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SPT6H_CAEEL !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SPT6H_CAEEL !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SPT6H_CAEEL !!

Protein-Protein Interaction

Oops, there are no PPI records of SPT6H_CAEEL !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.