dbPTM

DRE2_CAEEL - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	DRE2_CAEEL
UniProt AC	P41847
Protein Name	Anamorsin homolog {ECO:0000255\|HAMAP-Rule:MF_03115}
Gene Name	T20B12.7
Organism	Caenorhabditis elegans.
Sequence Length	238
Subcellular Localization	Cytoplasm . Mitochondrion intermembrane space .
Protein Description	Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery. Required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the cytosolic Fe-S scaffold complex. Electrons are transferred from NADPH via a FAD- and FMN-containing diflavin oxidoreductase. Together with the diflavin oxidoreductase, also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RNR), probably by providing electrons for reduction during radical cofactor maturation in the catalytic small subunit..
Protein Sequence	MSILSDFLKHPNLLQVTDGGPLVDGTNGVKGTRVVGSVSNARELRGADSLVGDVERAIIQVQETELLAEVCNTVFDVMKQNGEVIVFSQDLTTAQRKLRIAGFRVTEVAAEFPVRGIKLVNFGEKVALDLGVVADEDLIDEDGLLQEEDFEKPTGDQLKAGGCGPDDPNKKKRACKNCSCGLAEQEELEKMGQIAAEPKSSCGNCSLGDAFRCSTCPYLGQPPFKPGETVKISTVDDF

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference	Orthologous Protein Cluster
179	Phosphorylation	KRACKNCSCGLAEQE HHHHHCCCCCCHHHH	22.18	19060867

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of DRE2_CAEEL !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of DRE2_CAEEL !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of DRE2_CAEEL !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of DRE2_CAEEL !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of DRE2_CAEEL

Related Literatures of Post-Translational Modification