CHK1_CAEEL - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CHK1_CAEEL
• UniProt AC: Q9N3Z3
• Protein Name: Serine/threonine-protein kinase chk-1
• Gene Name: chk-1
• Organism: Caenorhabditis elegans.
• Sequence Length: 503
• Subcellular Localization: Cytoplasm . Nucleus . Cytoplasm, perinuclear region . The Ser-344 phosphorylated form colocalizes with P granules in a perinuclear manner in embryonic germline precursor cells and in Z2/Z3 primordial germ cells in L1 stage larvae.
• Protein Description: Serine/threonine-protein kinase which is required for checkpoint-mediated cell cycle arrest and activation of DNA repair in response to the presence of DNA damage or unreplicated DNA. [PubMed: 15326393 May also negatively regulate cell cycle progression during unperturbed cell cycles]
• Protein Sequence: MSAASTTSTPAAAAVAPQQPESLYRVVQTLGEGAFGEVLLIVNTKNPEVAAAMKKINIANKSKDFIDNIRKEYLLQKRVSAVGHDNVIRMIGMRNDPQFYYLFLEYADGGELFDKIEPDCGMSPVFAQFYFKQLICGLKFIHDNDVVHRDIKPENLLLTGTHVLKISDFGMATLYRNKGEERLLDLSCGTIPYAAPELCAGKKYRGPPVDVWSSGIVLIAMLTGELPWDRASDASQSYMGWISNTSLDERPWKKIDVRALCMLRKIVTDKTDKRATIEQIQADPWYQHNFGQVETPNGRPLKRARNNDENITCTQQAECSAKRRHLETPNEKSTLAERQNASFSQPTKTEDLLLTQHIDMSQTNSNLLQRMVCRMTRFCVVTDIRSTYQKVARASEHAGFGVRETDDYRLLVTWREVSMMVSLYTMGDIPDKPRVMVDFRRSRGDGIQFKKMFMDVRNRMHEWICTDGNNWLANLGYVPRNPQIVNGGGVNVEHSASSINVDV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
344	Phosphorylation	ERQNASFSQPTKTED HHHCCCCCCCCHHHH	32.52	26073019
495	Phosphorylation	GGVNVEHSASSINVD CCCCCCCCCCCCCCC	19.15	19530675
497	Phosphorylation	VNVEHSASSINVDV- CCCCCCCCCCCCCC-	34.46	19530675
498	Phosphorylation	NVEHSASSINVDV-- CCCCCCCCCCCCC--	20.21	19530675

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CHK1_CAEEL !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CHK1_CAEEL !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CHK1_CAEEL !!

Protein-Protein Interaction

Oops, there are no PPI records of CHK1_CAEEL !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.