| UniProt ID | MED12_CAEEL | |
|---|---|---|
| UniProt AC | Q20497 | |
| Protein Name | Mediator of RNA polymerase II transcription subunit 12 | |
| Gene Name | dpy-22 | |
| Organism | Caenorhabditis elegans. | |
| Sequence Length | 3498 | |
| Subcellular Localization | Nucleus . | |
| Protein Description | Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). Functions downstream of let-60 during vulval induction. Required for asymmetric division of T-cells and for hypodermal development.. | |
| Protein Sequence | MLRKTNLRMGTADVYKQNKNQEEDMLTTERLKKGYQMPLTQYELQSLVFNASENKLIRLEKAQKRSQSMIASVIHKKGEFHMNYDRERKIPKEQLPCFAPHNWKRILSDRVKFFSALARGTPLQQLSQRIPGFRRKELLFLEFSDYNISYDRAIWCVKLLCILGFNSSSKTQKKTLLDVATLELSQACNKTTIWLVTQLYKSFRNPIKRREATKTWNYLTGFMKYMFDDGVLDKQEFLNDLTEVFNQLFLQKNFKNPSVLSTFMKYYVYFVEDLSSSLVLARRSSTLLCQALGFLFEMAQDKRKIDAYYDSANKTFIKKEFENEDGEIYEFEDYDDFIDMLDEIPDVPYFDETDKTPEAQAEELIKQHEKRKAGSLKKSERRRRRGLSKNRPKKMPQNPSNEASLDHDKVQIKQEPMDYDEYGGQQSDNSMDYDSFSHQYDPSYEPLPFKPLHTDIPKKLTDDEEFKYMKIGKRSVTPERISGRYGSMTYPFWIQQGGVGIDPPKDEVLDFSNPTPTETVNTQPQIDFESSPSASPALSVDKENECEKKEDESKTKEKNKDKEKDKEKEKSVDEHTNDLDVPINPDDAEMADANDKTDASEKQKLVEEEPTGKENEDDTSSKTAKTSTSAEKSEAPSIVDSNDKIDKEPNASSTSNDETSKDDTVPMESDPPAATEKPKESTEITTEEPLEVDKAPEVDKSEKEHEDDIMIIESNKKADEDDCVVIAVVDPDQEQTPESEKKKDGEEERDKNKDTDVADNEPEKIYTDEELAEIKIRKEKEMKIATLASHIKEKMVSDKKWKEKTSHAGWRTLDQCSQFSEALHLLSSMVQYMACVTPESFVWNDLSVQQEERRHRILPQLCGSPLDYLPCELHKLPVMEGVEEVVDCLRLRHCEIVRRSQAAEDRWLPNAAFLQSFGRIIDTCVDVIGIMDNIDVEKPNAITNAGLRLFAFREKFEKQEALLKTMLMFKWCITEEREGSFRATYIAKLLRFGMDQNPENTIGGWQVMDLFFKFMSTEGPKHGSKMYQAHFDSTVAIMIEMMREKIFSITDILRELEKDSDLDYNAPLMERQRKQKIPKISKRHRKPETPDDTKLVHFTTEYTPKRLFMGKKMDLLERMIIILPQLDVDEDTDEYRLRRLLLFGLKPAANVYFRRARAIYKSITKEFTTRLYIEFDRSSKVTTAHKKINQNRLDDLLRQFRAQTYHDQHLILERIVYNFIDGIGGFLKKNCDDVPAPEVANIICEMYEFSMDITSIFDFFEMVNPYLKAVDDKIAHFRMDVLPDMYYTETAFIFVSFFMKHWQRFLLHPRACAIVNQCFVLIQDMIRADDHMITCWGRTVAIFVFHARKAIANAGLQNEEFLAEDSHFWRVFPNAQHVDLDVGYFNEDFAGVKLQLRGGTLRYDSYNDFKWLVSNMKPNLKKKPHLKRPNTRYSFVVRAFMEARQHGRNFDRINELANYCANITANDPPLSEYWIGAIKGLCFLSLDAPYPFKEMSQQIDISDCSTHYSLTTFITCLAGKSAFYIPRLLAELTKHVFPLMLRHDGRLTSQKTHDVKRKVASKTTESRTLSEAEPGVCLCLLIICGLCCVGDEPFGLSVHYRGIEKKKKRFNNTADERIMHLFHWFEMDHAMFRTLGHISQLLEALQSRCRDANLVLPKNFPIKNPPKHQQELHREKAPYRPQYLFNIAKTVQFVICEQDWVTLRMFRFFQTRKMEAFNQDKLKQNCLGQQILRMALRRRTERENVHKLFEAHKISKKATVDKVLSFMNLWNFRATLFDLMLMIKEISPDGNSRHAQQGAIAADALMSEIGKCCRDMFLSAYKTKIKMPIAKTLTDFRLSDINKFWLIAPLVRMCPKPINIPPQYANTTVGTVAAKFLREAALLMDTPPTTPKERLLQCSWAMSKVPFINMILTCLQCEKMQQSKDVFLQSLYTQLQRETLRDHHRRSNWTNRREHRDCTIFRITLIGYIYKEILKATHVETWGLLIFQLMFHGIINPVREKLIYETCFDMLHHMVLWTLVDGDSMNQHDRYGSIRVRWPQYAGLMKKIRKEMQERFTDQTRNSLHRFLPIGKMQMSTISYKKYQKRPKVNQKMSKKFLAGEGLKNGKYSFLPEEKAKTNAFEHTDHLGDLIVKGGWKFRMFQTTRLDKVAKNVQNVLRSNMHHTHVLEFNRPQLLMSDNMFDDIFLAPPDIEITKIIEQPVPVIDEEEAKKRAEEEKEAAEKKEESKNAEDEKNKNNAENKKDTKEGEKGKSKDKEKDGEKEKCKDASKKDDVTSEKNELEKRASDAAAATNAPETNKDMDTSTPKPAPVTRSPATRGRGGGRKRNSGARGGGPRAKRANSRADTAQAAAATTQWNAPIANTSNPAAGGNFHAAMRGNQPPMSNGSSDETKVHIRNLLNRKKEEKRNSLADASAAAAAANSNAMGNTSSMPPSGPPMPMGSSMQSAGATQQLQGMQKHQMGGSMSGMNQNMGGMNQSMSHQAPPPYSSTNEMNRPLMNQYGGPHFAAPNPGPLNRSSGPVSSETRQQIMEQQMREKLAAHHQLVEQQKQRDAREREAREREAREHQERMQREAYMKEQQLLERKRAIEENNRIMEEQQREREMEAARKEAARRAAEEAYAAEQQRLELLRRQEEERLRKEAEERMRIQRENEERVRQEQMRLEAEERERIRRAEEERIQKELEDKVRREKEEAARQEKERQEQEARMREAREAELSRQRMEQQRRSQQNPYMNQQGQYSQQPPPSYQQSSYPNNYQPGQQGNQPPNYQQPSHQSMQQGHQAGYQQTSNQMQMNMQQQQNRQQGGPQQSFSGPGGINQPSQPGYSGYNQQGGQGQQGQMQQQRNPFGNQQDMQQPGAAKLMHAKPNEAHAQQYQHTQNQLSLAQKEKEKQYFQAKNLQASQANAQQQQQRFGDVVAGNVAGYGRPYGQQQLGASDQMGTSQLPGASTSRMNQGSSNPQGGMQSYQQQQPVLGQPGPIQTGQSTQQQIPAQSQQQYNSGRPQMHTTPTKNDMSARAPSGAMGQIANRMGHGTNPQGYGSTGQNVPGGYQQGQQQSGQGSYPQAQQQQPNQYSGSNQQVGQQAQQQQQQPLNQNVSQSQSAAQFGRPSQDSAYQQSGYNQTGNQSYQRPDQQQQGAQQNQWSGSNQAQNQLRSQQQAQQPLQQPQQSQQFQQPAQQAKNPMAQSAQYGGFGGQQQGYDQQQQGQIAPQQAQNPQASQSYGQQQTQQNRYGMGSSGYTANSGGSSNILNQSMEESGLNQGFSGASSNASSQQGGSSQMQQSGYGMPGNQMQMQQNQKQQVQRGMPTGMGQTNMGQSGMGQSGMGQTGMSRSGLGGGIGQQGQQSQQPQQPQVSQQQNQRGMNPGAQLPPYSTGQQQHQPQQSQISQQQQQQDQYRRMQAAQMQQQPTAQGQQNRMGMPSQQQSGAAYSNQMQFQGVRQGQQGMGGMGGSGQQQPQTQPHGSNQYYQQQQDQRMQQQPQQPGQQQQHGYGMGQYPNQQPPNQY | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 2285 | Phosphorylation | NELEKRASDAAAATN HHHHHHHHHHHHHHC | 31.64 | 28854356 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of MED12_CAEEL !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of MED12_CAEEL !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of MED12_CAEEL !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of MED12_CAEEL !! | ||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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