SSP1A_CAEEL - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SSP1A_CAEEL
• UniProt AC: P41848
• Protein Name: FACT complex subunit SSRP1-A
• Gene Name: hmg-4
• Organism: Caenorhabditis elegans.
• Sequence Length: 697
• Subcellular Localization: Nucleus . Chromosome.
• Protein Description: Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II. Binds specifically to double-stranded DNA (By similarity)..
• Protein Sequence: MAELQFPGVYVEDVGHLAFGTLKLTEKSLNFKGDKGGKSVNVTGSDIDKLKWQKLGNKPGLRVGLNDGGAHRFGGFKDTDLEKIQSFTSSNWSQSIDQSNLFIKGWNYGQAEVKGKTVEFSWEDKPIFEIPCTNVSNVIANKNEAVLEFHQNDDSKVQLMEMRFHMPIDLENEEDADKVEEFKKAVLAYAGLEAETEQPICLLTDILCTTPRGRYDIKVYPTSIALHGKTYDYKIPIKSINRLFLVPHKDGRHVYFVLSLNPPIRQGQTRYSYLIFEFGKDEEQDLELALTDEQLESSNGNLRRDMTGPIYETISILFKSICNLKITVPGRFLGSSGTPAIQCTHRQNPGLLYPMEKGFLFIHKPAMYIRFEEISSCHFARSDSGTVTRTFDFEIDLKYGGPLTFNAMEKEENNKLFDYLNKKNIKIRNSQRVENTVADSSDDEIDPYKAAVTAEGRQRDDSDDDSTDEDYDLDKDIKKKKEDKESSEGTGSEPDDEYDSGSEQDSSGTGESEPDSEQDVPSKRRKGEPKEKREKKEKREKKEGKKGKKDKDPNAPKRATSAYMQWFLASRNELKEDGDSVADVAKKGGAKWKTMSSDDKKKWEEKAEEDKSRYEKEMKEYRKNGPPSSSSKPSSSKTSKKSSGPSSSKAISKEYISDSDDSDDEEPKKKEKKAAPKEESEESNNGSDGSDESDDSD

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
440	Phosphorylation	VENTVADSSDDEIDP HEEEECCCCCCCCCH	26.40	28854356
441	Phosphorylation	ENTVADSSDDEIDPY EEEECCCCCCCCCHH	50.02	28854356
462	Phosphorylation	EGRQRDDSDDDSTDE CCCCCCCCCCCCCCC	47.42	30078680
466	Phosphorylation	RDDSDDDSTDEDYDL CCCCCCCCCCCCCCH	44.76	19060867
467	Phosphorylation	DDSDDDSTDEDYDLD CCCCCCCCCCCCCHH	50.86	19060867
471	Phosphorylation	DDSTDEDYDLDKDIK CCCCCCCCCHHHHHH	19.16	30078680
655	Phosphorylation	SKAISKEYISDSDDS CCCHHHHHCCCCCCC	14.95	30078680
657	Phosphorylation	AISKEYISDSDDSDD CHHHHHCCCCCCCCC	30.11	19060867
659	Phosphorylation	SKEYISDSDDSDDEE HHHHCCCCCCCCCCC	36.20	30078680
662	Phosphorylation	YISDSDDSDDEEPKK HCCCCCCCCCCCCHH	52.53	19060867

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SSP1A_CAEEL !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SSP1A_CAEEL !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SSP1A_CAEEL !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PAL1_CAEEL	pal-1	physical	14704431

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.