PAR6_CAEEL - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PAR6_CAEEL
• UniProt AC: Q9NAN2
• Protein Name: Partitioning defective protein 6
• Gene Name: par-6 {ECO:0000312|EMBL:CAB61018.2}
• Organism: Caenorhabditis elegans.
• Sequence Length: 309
• Subcellular Localization: Cytoplasm . Cell membrane ; Peripheral membrane protein . Cell junction, tight junction. Membrane-associated at the periphery of blastomeres up to about the 50 cell stage. Peripheral expression is asymmetric in the cells of the germline lineage P0, P
• Protein Description: Necessary for apicobasal and anterior-posterior asymmetries associated with cell adhesion and gastrulation during the first few cell cycles of embryogenesis. [PubMed: 8898226 Required for localizing/ maintaining par-3 at the cell periphery]
• Protein Sequence: MSYNGSYHQNHHSTLQVKSKFDSEWRRFSIPMHSASGVSYDGFRSLVEKLHHLESVQFTLCYNSTGGDLLPITNDDNLRKSFESARPLLRLLIQRRGESWEEKYGYGTDSDKRWKGISSLMAQKPPKRSYSISNPEDFRQVSAIIDVDIVPEAHRRVRLCKHGQERPLGFYIRDGTSVRVTERGVVKVSGIFISRLVDGGLAESTGLLGVNDEVLEVNGIEVLGKTLDQVTDMMVANAHNLIITVKPANQRNTLSRGPSQQGTPNASEMSAATAAATGGIQRPMKMNGSSDGSYHPKQHDANDSDSGED

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
131	Phosphorylation	KPPKRSYSISNPEDF CCCCCCCCCCCHHHH	22.31	19060867
289	Phosphorylation	RPMKMNGSSDGSYHP CCCCCCCCCCCCCCC	21.91	28854356
304	Phosphorylation	KQHDANDSDSGED-- CCCCCCCCCCCCC--	33.22	30078680
306	Phosphorylation	HDANDSDSGED---- CCCCCCCCCCC----	48.29	30078680

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PAR6_CAEEL !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PAR6_CAEEL !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PAR6_CAEEL !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
KPC3_CAEEL	pkc-3	physical	21857670
FEM2_CAEEL	fem-2	physical	18502413
FEM3_CAEEL	fem-3	physical	18502413
FEM1_CAEEL	fem-1	physical	18502413
DCTN2_CAEEL	dnc-2	physical	18692475

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.