KPC3_CAEEL - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: KPC3_CAEEL
• UniProt AC: Q19266
• Protein Name: Protein kinase C-like 3
• Gene Name: pkc-3 {ECO:0000312|WormBase:F09E5.1}
• Organism: Caenorhabditis elegans.
• Sequence Length: 597
• Subcellular Localization: Cytoplasm . Cytoplasm, cytoskeleton . Targeted and anchored at the apical surface (villi) of intestinal and pharyngeal cells, and in proximity with the cortical actin cytoskeleton that lies under the plasma membrane. Tightly bound to organelles/cytos
• Protein Description: Required for the normal progression of embryogenesis and viability of the organism. [PubMed: 9422779 Plays an indispensable role in establishing embryonic polarity and in recruiting and maintaining par-6 to the periphery, through interaction with par-3]
• Protein Sequence: MSSPTSLEEDGDIKLKTRFQGQVVVLYARPPLILDDFFALLKDACKQHKKQDITVKWIDEDGDPISIDSQMELDEAVRCLNSSQEAELNIHVFVGKPELPGLPCQGEDKTVYRRGARRWKKIYLYNGHRFQAKRLNRRIQCFICHDYIWGIGRQGFRCVDCRLCVHKKCHRHVRTHCGQALQGPNIIPMAPASGSLKGARSNTSSSTTRSGGGIDNGAFHEHEIESPGSTSHDASRAMNGNGSSKWAVSLNDFRLLTVIGRGSYAKVVQAEHVSTRQIYAIKIIKKEMFNEDEDIDWVQTEKSVFEAASNYPFLVGLHSCFQTESRLFFVIEFVPGGDLMFHMQQQRKLPEEHARFYSGEIILALHFLHSRGIIYRDLKLDNVLIDAEGHIKLTDYGMCKENIKDGDLTSTFCGTPNYIAPEILRGDEYGFSVDWWALGVLMFEMMAGRSPFDIVGMQNSEENTEDYLFQIILERQIRIPRSLSVRASGILKGFLNKDPTERLGCKLDINEGLRDMKEHQFFRGFIDWEALEQKAVAPPYHPAVESDRDLTHFDHQFTDELPQLSPDNPDVIARIDQSEFDGFEYVNPLQMSREDSV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSSPTSLEE ------CCCCCCCCC	45.05	18806794
3	Phosphorylation	-----MSSPTSLEED -----CCCCCCCCCC	30.79	18806794
5	Phosphorylation	---MSSPTSLEEDGD ---CCCCCCCCCCCC	48.14	19530675
6	Phosphorylation	--MSSPTSLEEDGDI --CCCCCCCCCCCCE	36.85	19530675
193	Phosphorylation	IIPMAPASGSLKGAR EEEECCCCCCCCCHH	28.05	30078680
195	Phosphorylation	PMAPASGSLKGARSN EECCCCCCCCCHHCC	25.14	19060867
203	Phosphorylation	LKGARSNTSSSTTRS CCCHHCCCCCCCCCC	31.09	30078680
204	Phosphorylation	KGARSNTSSSTTRSG CCHHCCCCCCCCCCC	26.92	30078680
210	Phosphorylation	TSSSTTRSGGGIDNG CCCCCCCCCCCCCCC	39.43	28854356
249	Phosphorylation	GSSKWAVSLNDFRLL CCCCEEEECCCEEEE	17.44	19530675
409	Phosphorylation	NIKDGDLTSTFCGTP CCCCCCCCCCCCCCC	30.38	19060867
410	Phosphorylation	IKDGDLTSTFCGTPN CCCCCCCCCCCCCCC	27.12	18806794
411	Phosphorylation	KDGDLTSTFCGTPNY CCCCCCCCCCCCCCC	20.08	28854356
415	Phosphorylation	LTSTFCGTPNYIAPE CCCCCCCCCCCCCHH	15.00	19530675
565	Phosphorylation	TDELPQLSPDNPDVI HHCCCCCCCCCCCCE	25.59	28854356
585	Phosphorylation	SEFDGFEYVNPLQMS HHCCCCEECCCCCCC	11.85	30078680
592	Phosphorylation	YVNPLQMSREDSV-- ECCCCCCCCCCCC--	21.40	30078680
596	Phosphorylation	LQMSREDSV------ CCCCCCCCC------	25.60	30078680

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of KPC3_CAEEL !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of KPC3_CAEEL !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of KPC3_CAEEL !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PAR6_CAEEL	par-6	physical	14704431
LIN5_CAEEL	lin-5	physical	21857670
PSMD1_CAEEL	rpn-2	physical	18502617
PAR6_CAEEL	par-6	physical	18502617

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.