PSMD1_CAEEL - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PSMD1_CAEEL
• UniProt AC: Q18115
• Protein Name: 26S proteasome non-ATPase regulatory subunit 1
• Gene Name: rpn-2
• Organism: Caenorhabditis elegans.
• Sequence Length: 965
• Protein Description: Acts as a regulatory subunit of the 26 proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins..
• Protein Sequence: MLTLLNRWRSQPGGASNAAAFIRVLESPKSAVTDKVLVLKAFNDWDVLVNTWFEVADALPAVEQLLDNNTFPEHSSAALLVSKVYFCLEQYERALEFALRGDFNVVPATRTGLGNDAEYVNKIIETAIDTYKTLSKQGSGIPQKLRDLIDRIVARNLDKREIWFVISLGFETTNLAMIDRAISAMPADLTIKNQTTLVETLNRVVNGAFDRSFRFQVIDTVIKTYLKCPSPDMSKICECYVLTDNAEAAADTITSLIAKSLSTRAYQIAFDLYETASQGFLDRVLKRFQQQDARDEKSMEKIHSILKGHETVKAYLDFFVRHNHTDSVLMEEIKENIRTASAHNALLISNGLMQYGTTCDDFLRNNLNWVSKATNWNKFNAVASLGLIHHGQESSAMKVLEPYLPKESVEGFGFKEGGAMLAYGLIHAKHGDATAMSTLAQWLKTAENEPVRHGACLGFGVAGLGSSSVSNYEKVREVLQRDEAVSGESAGIAMGLIMAGHLNQEVFNELKQYTVDTQHDKTQRGIRTGLACAAFGLQGDAEPYIKEAIGAKSNPMLRSTGICMLSMAYAGTGSPDVVRRLLEKVATDPNLDVKRYATIGIGFVLSKDPSTCLSYVAMLTEHFNGHVRYGAAMALGIACAGTGNMEAIALIEPMISDKEGFVRKGALLSLALIMCQQTDYTCPKVNGFRKQLLKKIGEKNEDSLVKFGAIIAQGLLDIGGQNAAVTMQNSDKQPDMGSMVGMMCFLHGWFWHSMHFFIALAAKPSCLVMMNENLKIPVLDYICHANSQKFAYPPRAESKKDKDVKKIETVVLSITGKKNASKKLIAEEKKRREAAASASSAAAAPSSSSTSGTAPAAEDEKMEVDQPGKSKKEKAPEKDTKPLHRLQNPARVIPAQRQLISISDARAYSPMKPLYKGGIIVADRVDKEREEKLVSEVVTQVNTPASSGNTENKPHSTFEININDF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
837	Phosphorylation	KRREAAASASSAAAA HHHHHHHHHHHHHHC	24.77	30078680
839	Phosphorylation	REAAASASSAAAAPS HHHHHHHHHHHHCCC	20.29	30078680
840	Phosphorylation	EAAASASSAAAAPSS HHHHHHHHHHHCCCC	22.95	30078680
935	Phosphorylation	EREEKLVSEVVTQVN HHHHHHHHHHHHHCC	34.80	30078680
939	Phosphorylation	KLVSEVVTQVNTPAS HHHHHHHHHCCCCCC	31.79	30078680
943	Phosphorylation	EVVTQVNTPASSGNT HHHHHCCCCCCCCCC	22.75	30078680
946	Phosphorylation	TQVNTPASSGNTENK HHCCCCCCCCCCCCC	39.73	30078680
947	Phosphorylation	QVNTPASSGNTENKP HCCCCCCCCCCCCCC	37.86	30078680
950	Phosphorylation	TPASSGNTENKPHST CCCCCCCCCCCCCCE	44.45	30078680

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PSMD1_CAEEL !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PSMD1_CAEEL !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PSMD1_CAEEL !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
HSP7C_CAEEL	hsp-3	physical	14704431
EF1A_CAEEL	eef-1A.1	physical	14704431
ADRM1_CAEEL	C56G2.7	physical	18692475

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.