LIN5_CAEEL - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: LIN5_CAEEL
• UniProt AC: P45970
• Protein Name: Spindle apparatus protein lin-5
• Gene Name: lin-5
• Organism: Caenorhabditis elegans.
• Sequence Length: 821
• Subcellular Localization: Cytoplasm, cell cortex . Cytoplasm, cytoskeleton, spindle . Chromosome, centromere, kinetochore . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Located to the spindle apparatus in a cell cycle- and microtubule-dependent manner.
• Protein Description: Essential component of the spindle apparatus required for spindle positioning and chromosome movement. Acts to recruit or anchor gpr-1/gpr-2 complex to the spindle and cortex. Also involved, directly or indirectly, in cytokinesis and in the coupling of DNA replication, centrosome duplication and mitotic division..
• Protein Sequence: MSVSTSVVKSMLQLTNYFGSNFTPKTETISSLAELWERHGSMIASMMSCDTREFGTADKFYEVIFRKIATTSLSFMTDSLEPKLAASGDSLEICKFYALFLEYMRKDHSGMLTRALEQASSENRVDTAVLLDMFLFFDNVYSESTADDWWACLRRDDEDQEASSGFRTPKRNNYSLTSLQTPTATARRLRTASSTARRSPIAEAVDSPTMKFMRSERELKQSKARIFGLEQMLGDLEDDKTKLSAENRTLKLSNSDLKSDIAKLKGIAEEAQFRAEELSCDLEAKKDEVHNILQQLNESRMTLRSEQRSLEEADIKKENLTAKLKTVTEDNGKLMKQARELRDLNDYEFARFRQQEQELTETLRATQDQMADLQEQLTGVEKIRASLKSENESLSASVEELSVASLRNKQDADNSKTMLSEELARFEETVDKLRQEKLEALSMANSRIDALRLEHSEREKMMKSTNARLQADLDEERNEKKRLMNLWNELNEKSLNVDKAVHKSNEEFQSMGSCLQNAKRQIEQLEVACKSKDDIIKFQEEQNKRAANLIKNEKAIRDQASAQFAEKLAILKNSLAEKENETVTLKENFASVVMKHKAELEEKELFLQSRVDLIQRLEHEVADLREKESAEIKKSTWMGERIKIFQQAPMRGSRIRCGSPDSLPDFLADNGPTITEEELRAQLATFPRKSIAPSVDDNEFDKGTPIGFKSNMYDGRESICSLDFFDRSSLQRSSMRSESIQLASPSSAGEFKQPFTPSGVTKERVGVLTARNEKVKPHLKCSYASEVGSTNSPSADEENIKKSKKKNRRDSIFSAFSSKKQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
163	Phosphorylation	DDEDQEASSGFRTPK CCCCHHHHCCCCCCC	30.18	30078680
164	Phosphorylation	DEDQEASSGFRTPKR CCCHHHHCCCCCCCC	49.34	30078680
168	Phosphorylation	EASSGFRTPKRNNYS HHHCCCCCCCCCCCC	30.79	30078680
199	Phosphorylation	ASSTARRSPIAEAVD HCCCCCCCCCHHHCC	18.33	30078680
207	Phosphorylation	PIAEAVDSPTMKFMR CCHHHCCCHHHHHHH	18.70	30078680
659	Phosphorylation	GSRIRCGSPDSLPDF CCEECCCCCCCHHHH	29.21	30078680
662	Phosphorylation	IRCGSPDSLPDFLAD ECCCCCCCHHHHHHC	45.23	30078680
690	Phosphorylation	LATFPRKSIAPSVDD HCCCCCCCCCCCCCC	25.84	19530675
694	Phosphorylation	PRKSIAPSVDDNEFD CCCCCCCCCCCCCCC	29.20	30078680
744	Phosphorylation	SESIQLASPSSAGEF CCCCEECCCCCCCCC	33.63	30078680
746	Phosphorylation	SIQLASPSSAGEFKQ CCEECCCCCCCCCCC	30.26	30078680
747	Phosphorylation	IQLASPSSAGEFKQP CEECCCCCCCCCCCC	43.61	30078680

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of LIN5_CAEEL !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of LIN5_CAEEL !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of LIN5_CAEEL !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RL4_CAEEL	rpl-4	physical	14704431
RM11_CAEEL	mrpl-11	physical	14704431
HSP7D_CAEEL	hsp-4	physical	14704431
RETR1_CAEEL	retr-1	physical	14704431
SPE26_CAEEL	spe-26	physical	14704431
LIN5_CAEEL	lin-5	physical	18692475

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.