dbPTM

FEM2_CAEEL - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	FEM2_CAEEL
UniProt AC	P49594
Protein Name	Protein phosphatase fem-2 {ECO:0000305}
Gene Name	fem-2 {ECO:0000312\|WormBase:T19C3.8}
Organism	Caenorhabditis elegans.
Sequence Length	449
Subcellular Localization
Protein Description	Dephosphorylates auto-phosphorylated Ca(2+)/calmodulin-dependent protein kinase unc-43/CAMKII in vitro. [PubMed: 11559703]
Protein Sequence	MEKVNEERDAVFEDHIGDRRRSVRSLLEEAFADEMEKTSYDVEVADTPQPHIPIRFRHPPIAGPVHDVFGDAIHDIFQKMMKRGQAVDFCHWVSHLIATEIDEKFSEVAFRDVQYNPDIYVTDSTTEAKKLFNDKIWPAIDKILQQNAETCPILSEKWSGIHVSGDQLKGQRHKQEDRFLAYPNGQYMDRGEDPISVLAVFDGHGGHECSQYAAGHLWETWLEVRKSRDPSDSLEDQLRKSLELLDERMTVRSVKECWKGGSTAVCCAIDMDQKLMALAWLGDSPGYVMSNIEFRQLTRGHSPSDEREARRVEEAGGQLFVIGGELRVNGVLNLTRALGDVPGRPMISNEPETCQVPIESSDYLVLLACDGISDVFNERDLYQLVEAFANDYPVEDYAELSRFICTKAIEAGSADNVSVVIGFLRPPQDVWKLMKHESDDEDSDVTDEE

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference	Orthologous Protein Cluster
Oops, there are no PTM records of FEM2_CAEEL !!

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of FEM2_CAEEL !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of FEM2_CAEEL !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of FEM2_CAEEL !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
FEM1B_HUMAN	FEM1B	physical	11559703
FEM1_CAEEL	fem-1	physical	17609115
FEM3_CAEEL	fem-3	physical	17609115
KCC2A_HUMAN	CAMK2A	physical	11559703

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of FEM2_CAEEL

Related Literatures of Post-Translational Modification