CDK12_CAEEL - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CDK12_CAEEL
• UniProt AC: P46551
• Protein Name: Cyclin-dependent kinase 12
• Gene Name: cdk-12
• Organism: Caenorhabditis elegans.
• Sequence Length: 730
• Subcellular Localization: Nucleus .
• Protein Description: Cyclin-dependent kinase which displays CTD kinase activity: hyperphosphorylates 'Ser-2' in the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit, thereby acting as a key regulator of transcription elongation. Required for normal reproduction..
• Protein Sequence: MEISPGSSTHERDRKGSYGHRERTRSHSGSPSRFYSKDKRGSSRQGVRPRDRDSKDSISPQYKQRNWSRGGGGGGRDRGRNDFSYRKKGKDYNKRRDKRSRSRSRHRSPKRSGSSKKSKRRNSSGSSSSDLMDTSLMSELKKHGDYGSSSKSKKKSRKRRKHSSSSSSSSGEAMDLPVSSNGMNVTAIPPPPSFNINPFQPMFSQPPPPPLPPNSQFMTPPPRPPPAPFSIPPPSVDIHFAATASFSLSSIPPPPPQTDGGASSSKRQDPLPMPPDSKRIATRPVITTRRGHATNRPSDSDSWYKTNLTHYTMLDQIGEGTYGQVYKAVNNLTGEQVALKRVRLENEKEGFPITAIREIKILRQLHHKNIVRLMDIVIDDISMDELKRTRANFYLVFEYVDHDLIGLLESKELVDFNKDQICSLFKQLLEGLAYIHNTGFLHRDIKCSNILVNNKGELKIADLGLARLWEKESRLYTNRVITLWYRPPELLLGDERYGPAIDVWSTGCMLGELFTRKPLFNGNNEFGQLELISKVCGSPNVDNWPELTELVGWNTFRMKRTYQRRIREEFEHIMPREAVDLLDKMLTLNPEKRISAKEALNHPWIRSLEHTTVQPLKLPQHQDCHEMWSKKQKKSARLGRQAEGSSGSGHSIRATSHPRAPTQPSTTTTKSNGSSNHHHHHHHSHHHASSLPPSGGHAPPPPPPPTQASSTSHNNHQPVPQSQYQSVFFK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
4	Phosphorylation	----MEISPGSSTHE ----CCCCCCCCCCC	15.20	28854356
7	Phosphorylation	-MEISPGSSTHERDR -CCCCCCCCCCCCCC	35.13	19530675
8	Phosphorylation	MEISPGSSTHERDRK CCCCCCCCCCCCCCC	39.43	18806794
9	Phosphorylation	EISPGSSTHERDRKG CCCCCCCCCCCCCCC	29.47	19530675
17	Phosphorylation	HERDRKGSYGHRERT CCCCCCCCCCCCHHC	30.86	19530675
24	Phosphorylation	SYGHRERTRSHSGSP CCCCCHHCCCCCCCC	31.60	30078680
26	Phosphorylation	GHRERTRSHSGSPSR CCCHHCCCCCCCCCC	22.76	30078680
28	Phosphorylation	RERTRSHSGSPSRFY CHHCCCCCCCCCCCC	42.06	30078680
30	Phosphorylation	RTRSHSGSPSRFYSK HCCCCCCCCCCCCCC	23.79	30078680
32	Phosphorylation	RSHSGSPSRFYSKDK CCCCCCCCCCCCCCC	36.40	30078680
59	Phosphorylation	RDSKDSISPQYKQRN CCCCCCCCHHHHHCC	15.20	30078680
127	Phosphorylation	RRNSSGSSSSDLMDT CCCCCCCCHHHHHCH	37.07	30078680
128	Phosphorylation	RNSSGSSSSDLMDTS CCCCCCCHHHHHCHH	29.57	30078680
129	Phosphorylation	NSSGSSSSDLMDTSL CCCCCCHHHHHCHHH	36.39	30078680

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CDK12_CAEEL !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CDK12_CAEEL !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CDK12_CAEEL !!

Protein-Protein Interaction

Oops, there are no PPI records of CDK12_CAEEL !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.