CCNE_CAEEL - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CCNE_CAEEL
• UniProt AC: O01501
• Protein Name: G1/S-specific cyclin-E
• Gene Name: cye-1 {ECO:0000312|WormBase:C37A2.4a}
• Organism: Caenorhabditis elegans.
• Sequence Length: 524
• Subcellular Localization: Nucleus . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole . Co-localizes with cdk-2 in the sperm centrioles before the first embryonic mitosis and then to the male and female nuclei upon entry into mitosis.
• Protein Description: Essential for the control of the cell cycle at the G1/S (start) transition. [PubMed: 12606285 In association with cdk-2, regulates proliferation, quiescent state and cell fate during the development of several cell lineages]
• Protein Sequence: MAGRKSSRTAERVPTTQKPERKSAILSPHDELRERLLETAIDMKENIPQRNTRNSSVGSQKSDCSETRKRRSTKEGPAAKRHSGEKHRNGSREDSLEYISEYSDDREVGSSSSQSSRTRGQPLPAMPEEEEVFDKSSSSDNLAESEESHEMVRLEERQDIEEEIEDDFDDEEEDVVNDKEEYEEIESEDEDDYPVQNEGFAVTKRLMNDEHMVTAPTFLSTAKCDGIGSPTKVWSLMVKRDEIPRATRFLLGNHPDMDDEKRRILIDWMMEVCESEKLHRETFHLAVDYVDRYLESSNVECSTDNFQLVGTAALFIAAKYEEIYPPKCIDFAHLTDSAFTCDNIRTMEVLIVKYIGWSLGPITSIQWLSTYLQLLGTGKKNKSDHYEEQNMYVPELLRSEYLEMCKILDFLLFEIDSFTFSYRTIAAAVLFVNYEPTCAVEKATGFMQAQLEKVIEYVEPVCRAFAKQRQLLDDVIPKHESIKSDDSHNIQVYVKRSSMEPIVKSERERIQHLKARRLHPQRLF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
27	Phosphorylation	ERKSAILSPHDELRE CHHCCCCCCCHHHHH	17.67	30078680
136	Phosphorylation	EEEVFDKSSSSDNLA HHHHHCCCCCCCCHH	36.98	30078680
137	Phosphorylation	EEVFDKSSSSDNLAE HHHHCCCCCCCCHHC	39.33	30078680
138	Phosphorylation	EVFDKSSSSDNLAES HHHCCCCCCCCHHCC	49.12	30078680
139	Phosphorylation	VFDKSSSSDNLAESE HHCCCCCCCCHHCCH	32.25	30078680
229	Phosphorylation	AKCDGIGSPTKVWSL CCCCCCCCCHHHHEE	27.72	30078680

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CCNE_CAEEL !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CCNE_CAEEL !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CCNE_CAEEL !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
BAT42_CAEEL	bath-42	physical	18692475
SYAC_CAEEL	aars-2	physical	18692475
TPM1_CAEEL	lev-11	physical	18692475
TPM3_CAEEL	lev-11	physical	18692475

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.