dbPTM

SYAC_CAEEL - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	SYAC_CAEEL
UniProt AC	O01541
Protein Name	Alanine--tRNA ligase, cytoplasmic {ECO:0000255\|HAMAP-Rule:MF_03133}
Gene Name	aars-2 {ECO:0000255\|HAMAP-Rule:MF_03133}
Organism	Caenorhabditis elegans.
Sequence Length	968
Subcellular Localization	Cytoplasm .
Protein Description	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain..
Protein Sequence	MKHLTASEVRSTFINFFREKKEHTYVHSSSVIPHDDPTLLFANAGMNQFKPLFLGIADPNSDLAKLKRAVNTQKCIRAGGKHNDLDDVGKDVYHHTYFEMLGNWSFGDYFKKEIITWAWELLTTVYGIPAERLYVSVFGGDEANGVPADSEARDIWRSVGVPDERILNFGMKDNFWEMGDVGPCGPCSEIHYDRIGNRDASHLVNADDPMVVEIWNLVFIQFNREEGGVLKPLPAKHIDCGLGLERLIAVMQDKTSNYDTDIFQPIFEAIHKGSGVRAYTGFIGDEDKDGVDMAYRVVADHVRTLTIALSDGGRPDNSGRGYVLRRILRRGVRYASEKLNAQPGFFASLVPVVISILGETFPELSRDPVTVMDIINDEEKQFLKTLSRGRVLFQRAVQSLPEGTMTFPGDVSWRLYDTYGFPADLTQLMAEEKGLSVDNTAFEEARRKAIETSSAGTGKFRDTLDLDVHALAELQQKGVPTTDDSPKYAYTFTGEGSDAVYKFEPCVGKILAIRRDGKFVDQLAAGEEGAILLDRTNFYAEQGGQIYDVGVLTKVNDESNEFNVSNCQVRGGYIVLVGSAEGSFSVGDQVNERFDEDRKQLIMKNHTGTHVLNYALRKVLADSDQKGSLVAPDRMRFDFTNKAGMTVQQVKKAEEYAQQLIDTKGQVYAKNSPLGEAKKVKGLRAMFDETYPDPVRVVAVGTPVEQLLQNPDAEEGQNTTVEFCGGTHLQNVSHIGRIVIASEEAIAKGIRRIVALTGPEAERAIARADRLTARLEEESKHADKKDELLANKDKFKALQKKIQEIVDEANGAQLPYWRKDSIREKAKAIQKTLDGYTKAQQAAVAEKVLGEAKELAAVAEQPTVLVHVFAANANSKAIDNALKLLKDTKAVMAFSVNEDSGKVLCLAKVDKSLVSNGLKANEWVNEVCTVLGGKGGGKDANAQLTGENVDKLDAAVELAQKFALAAIN

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
485	Phosphorylation	GVPTTDDSPKYAYTF CCCCCCCCCCEEEEE	26.54	30078680
607	Phosphorylation	QLIMKNHTGTHVLNY HHHHHCCCHHHHHHH	53.84	19530675
609	Phosphorylation	IMKNHTGTHVLNYAL HHHCCCHHHHHHHHH	15.23	19530675
614	Phosphorylation	TGTHVLNYALRKVLA CHHHHHHHHHHHHHC	11.67	19530675
672	Phosphorylation	GQVYAKNSPLGEAKK CCEEECCCCCCHHHH	22.31	30078680

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of SYAC_CAEEL !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of SYAC_CAEEL !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of SYAC_CAEEL !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of SYAC_CAEEL !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of SYAC_CAEEL

Related Literatures of Post-Translational Modification