MUA3_CAEEL - dbPTM
MUA3_CAEEL - PTM Information in dbPTM
Basic Information of Protein
UniProt ID MUA3_CAEEL
UniProt AC P34576
Protein Name Transmembrane cell adhesion receptor mua-3
Gene Name mua-3 {ECO:0000312|WormBase:K08E5.3a}
Organism Caenorhabditis elegans.
Sequence Length 3767
Subcellular Localization Cell membrane
Single-pass membrane protein . Cell junction, hemidesmosome . Co-localizes with cytoplasmic intermediate filaments at hemidesmosomes.
Protein Description Involved in cell adhesion and required for organ positioning and attachment. [PubMed: 25917920]
Protein Sequence MQAGISIFFLFLHIPIFFVNCSNSTSCVAREEFQCKMDDSCISMKKWQDGVDDCYDGSDEVCLPWQFDCQFGSPRCISKNKLHDKKIDCYSGFDEGCPAHYFVCRDRSACIEPSKYLNGVADCKDKSDEPCAQNQFQCSDGTKCIPKAQFQDGKEDCDDGSDEECTTSQFACQCGTIKCVSDTFIMDGNWDCEDGSDEFINKTLTANCTRNNKVNIATNSLSLGKLKFCSGKNPCKPELGQVCVIIGGTWRCVCKLGTFRPLGSDKCIPIELLTRYRNAPSSKCSNSHEEQFGLLQGFQKSLSSRKELERWSNIRRAPPRTLSGTTPSGSDGFLKSGAEQVPFMFQEDKNYVSVIPDEIIDSYGTIMTPPEFHFNRDDIRCGNKTCGLHESCQKNSESKYECICREGFTIFEGTCRELIDECAQGKHDCHPEARCVDALIGYECLCREGYLDTSIDPKARPGRKCRKLINECTNALMNDCSQNARCLDKPIGYTCRCQDDYVDVSREGARKPGRNCTQAINECASNLHNCDTHAICQDQPVGYSCRCPFGFIDSSPTALEPGRKCVQANNEAATTSTTTSQCIKEKNGETVCKCLLGYKNVGTKTHLNCQMEKRANPCQDYSLHDCDPVAECFSEQPGYFQCQCPKGFTDSSADKRFPGRKCVRAVDECALGRHTCDPHADCIDTHQGYTCKCRSGWSDTSLDPLRSPGRSCKKADMCSNIDCAAEAECRETPIGPMCQCVSGYVDVSRQHGRPAGRVCRAVVNECAEGRHDCSSHATCIDTADGFTCRCKDSYRDESSDTLKHPGKNCVRTVQPDPPECDVSDPMSCDPAKREVCIFVENTYKCRCANGYSRLPDGRCVVINECAEPRLNTCGKNAECIDLAEGYTCQCRSGYADISPVSQPGRICRARVNECSNKEKYNVDCSENAICADTEHSYSCRCRPGFADVSAAFNKLPGRRCIEAVNECASPSLNDCSKNAFCEDAKEGYICTCRPGYVDNSPNAARHPGRICTKPVEKIKTDLKDTSFSTDDGCDPKNPKCGANEACVQRHGQHNCECVETAFRYTDGSCRVYSACSKRNTCDKNAICLNRFDSYTCQCRPGYIDLSADLTNAPGRICKELINECASSDNECSPYARCIDATNGYACQCLDGFIDVSSRYNKPPGRQCTNSNNECSEKSLNTCDENADCVDTPDGYTCQCYGGFVDVSSNANLPPGRVCTVQTTCPKQKTDLVFLIDGSGSIGSYVFKNEVLRFVREFVELFEIGRSKTRVGLIQYSDQIRHEFDLDQYGDRDSLLKGISETQYLTGLTRTGAAIQHMVQEGFSERRGARPQQSDIARVAIILTDGRSQDNVTGPADSARKLSINTFAIGVTDHVLASELESIAGSPNRWFYVDKFKDLDTRLRSMIQKAACPSPTKQETPSEDVCNPRTQTGCDRSLNEHCAVENGRPRCVCPEGFTRHPFTRVCGGDLCNPQLITSCIFPEECQITPYKNFRCSCPEGYNRDYRSGFCVSVKEVQISPQHDANCHNGGVRCSENERCTNDGSDWFCECLPGFERIRNGQCAYPGSCNPNDPMSCDVRKRQQCLPRGNIYTCQCGRNEKRHPITDICLKNECLTGEHDCDRSARCIDTDESYICACQSGFIDHSPNPSERPGRVCVALQNECLDGSNRCSPNALCTDTEEGYVCRCKSGFVDYSPNPQTFPGMVCKELVNECTNPRLNQCDRNAHCIDTIEGYSCICKPGFVDMDEFGNPGRRCEQIKTNDKCSPGKNDCDRNARCIQIGDDDYSCACPPGFKDKSPSSSRPGRLCIPVIPECDNPTLNDCDSPDRAVCTDTDDGYMCRCRQGFLDISPSISVKPGRLCKPLQNECALGIDDCARDGGICEDNPDSFTCRCAMNYLDVSFDRVTRPGRKCKRLINECQTGQNDCSEEATCTDTEDSYICACPQSHIDLSPDTVNRPGRRCLMRINECTSNRHDCSPNADCIDTPESYKCRCRDDFVDESPDSSRRPGRICRPALVDECRTGKHDCHVNAICQDLPQGYTCQCSADFVDVSPHRASHPGRLCQPRPTPPPPECRLDGGNQCKVHLNEVCRLMGGEPKCSCPVNYQRDSSGSCSIINECLFTQLNDCHTAADCIDQVQGYTCQCRDGFKDIGDRRRPGRMCKPMVNECQYPHLNDCHQNAACIDLEEGYECKCNQGFMDHSHGRPGRICKQLTNECLRPSLNSCDRNARCIDKEEGYECECRDGFIDVSPSPTLKGRACRELVNECANSRLNDCDKNARCKDTMDSYECDCPVNSKDISPSPSFPGRVCLMFINECESGVHDCDPSATCRDNEQSFTCECPSGFVDRSPNKHARPGRVCVKLVDECREGRHTCSSHADCRDLEEGYTCECRDGYVDRSPNLASQPGRVCSAPEVCPPNHDCSSAAVCEPLGGMKYQCVCIQGYVDQSPGSQKGRVCVRNNACHDPRLNTCSRNAICYDEPRGYRCECKRGFMDRSPDSSQRGRVCEPPPPPSPPPRHPCQDPERNDCHPAGTCRATGAQSYTCECLSGYADRSPDPRNKPGRLCVLTEPVCLDPEQNDCHAAAICSEVNGPEKYTCKCRDGYTDESPDPLRRPGRICKGLINECLDRSLNDCHSLAVCKDLPNGYTCQCPINAKDQSPDPRKPGRICSLSVNECANPSLNSCSAFADCFDEENGYRCRCRNGYHDDDPAHPGHRCSFMINECDSSNLNDCDRNANCIDTAGGYDCACKAPYRDEGPPQSPGRICRLNECLNPNRNTCDRNADCRDLDYGYTCTCRHGFYDQSPNPQEPGRICIEFQQEEHIERVKVTTVQSEPRREFPCGRDDCIKARGEVCISGEYCGCKPGEGRSASTGKCQEVQETPFELRVVTRDQRPLMYSTEFGSQKSPSYVEIVELFEKNMARTFGGTSLAPRYVNTKVDYITHPKTKNSSWDQGLLFKYEVQTTKSQSQPIDECELWKQMQASLDRTNGAIGGGSLRVASDTDLLNPCKQQEEWGNCGGMSCKEHLKEVCIAGHICGCPDGMKRRDANSECRVVESWNVPLWVVRDKEKPIVFSESFDNPQTPVYKDYSKRLEKGIEGCYPHTELKNAFVTAEVNDIVNPVLMNASYDTGLLFNTTVHFRKGMVHVPSDAYYQLIKYVTKENNNEVGDSELYLNPTQPDPFNPCFKNDCDPHGKCIEISKYAYKCECGVGYRDINPQSPGKKCLPVHGFNECERKEDNECSENARCIDLEHLYKCECLPSYYDTSPVGSVPGSLCVLDYCSDVNFCPTNTTCKNMEQQAECKCDAGFMDIRKSEKRTALMLGDDTLCMHVRDVDECALGLNNCSGVAHCIDRAVGYTCKCPDGYIDGNPDEPGRVCGALLCDLCNAHGDCVHNTATNNITCVCTDGWTGPQCQVAPSNASLVLLILLALLFLLLTLCCLLYFCTKCHCFKGRRFAGAGANGFGYRRGGAWPWSTLEGSASSESGAEFSAMSAAGNDYYPDIGIPRAKLKSGMMASGNTAEVRNMEVARLDQYLDENAVRIPRAHLVDAHGDTSFDSLSEASSEYTIKEEIERKVITDVTTKEIKTTTTTDEQGNTIVTTTEAVHPRDTTIVHGGGYTQNESSSSSFSGGERAYQSQSQQQQSMSQGMSQSMSQHATSAGYSSSGMESSAHNSGYASIRHTGERERGGSEEEFSIGRARGMAAASSGYQHSSSENREVEEYCSEEEDVEHSVGDKRTIVTKNHSYEPFVNGESERFKTEVVTSQTSTHVTKK
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
201N-linked_GlycosylationDGSDEFINKTLTANC
CCCHHHHHCHHEECC		36.26-
207N-linked_GlycosylationINKTLTANCTRNNKV
HHCHHEECCCCCCCE		23.58-
383N-linked_GlycosylationRDDIRCGNKTCGLHE
HHHCCCCCCCCCCCH		39.84-
515N-linked_GlycosylationGARKPGRNCTQAINE
CCCCCCCCHHHHHHH		38.82-
1350N-linked_GlycosylationTDGRSQDNVTGPADS
ECCCCCCCCCCCHHH		26.1317761667
2944N-linked_GlycosylationITHPKTKNSSWDQGL
ECCCCCCCCCCCCCE		46.6517761667
3120N-linked_GlycosylationIVNPVLMNASYDTGL
HHCHHHCCCCCCCCC		22.9017761667
3130N-linked_GlycosylationYDTGLLFNTTVHFRK
CCCCCCCEEEEEECC		34.5117761667
3285N-linked_GlycosylationDVNFCPTNTTCKNME
CCCCCCCCCCCCCHH		20.66-
3337N-linked_GlycosylationDECALGLNNCSGVAH
HHHHHCCCCCCCHHH		45.7417761667
3338N-linked_GlycosylationECALGLNNCSGVAHC
HHHHCCCCCCCHHHH		26.7817761667
3394N-linked_GlycosylationVHNTATNNITCVCTD
CCCCCCCCEEEEECC		26.96-
3414N-linked_GlycosylationQCQVAPSNASLVLLI
CCCCCCCHHHHHHHH		32.27-
3684PhosphorylationGERERGGSEEEFSIG
CCCCCCCCHHHHCHH		44.6630078680
3689PhosphorylationGGSEEEFSIGRARGM
CCCHHHHCHHHHHHH		27.6730078680
3716PhosphorylationENREVEEYCSEEEDV
CCHHHHHHCCCHHHH		6.4330078680
3718PhosphorylationREVEEYCSEEEDVEH
HHHHHHCCCHHHHCC		47.3330078680
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of MUA3_CAEEL !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of MUA3_CAEEL !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of MUA3_CAEEL !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of MUA3_CAEEL !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of MUA3_CAEEL

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Related Literatures of Post-Translational Modification
N-linked Glycosylation
ReferencePubMed
"Proteomics reveals N-linked glycoprotein diversity in Caenorhabditiselegans and suggests an atypical translocation mechanism for integralmembrane proteins.";
Kaji H., Kamiie J., Kawakami H., Kido K., Yamauchi Y., Shinkawa T.,Taoka M., Takahashi N., Isobe T.;
Mol. Cell. Proteomics 6:2100-2109(2007).
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-1350; ASN-2944; ASN-3120;ASN-3130; ASN-3337 AND ASN-3338, AND MASS SPECTROMETRY.
"Lectin affinity capture, isotope-coded tagging and mass spectrometryto identify N-linked glycoproteins.";
Kaji H., Saito H., Yamauchi Y., Shinkawa T., Taoka M., Hirabayashi J.,Kasai K., Takahashi N., Isobe T.;
Nat. Biotechnol. 21:667-672(2003).
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-1350, AND MASSSPECTROMETRY.

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