MUP4_CAEEL - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MUP4_CAEEL
• UniProt AC: Q21281
• Protein Name: Transmembrane matrix receptor MUP-4 {ECO:0000312|EMBL:AAK69172.1}
• Gene Name: mup-4 {ECO:0000312|EMBL:CCD63613.1, ECO:0000312|WormBase:K07D8.1}
• Organism: Caenorhabditis elegans.
• Sequence Length: 2104
• Subcellular Localization: Cell junction, hemidesmosome . Cytoplasm, cytoskeleton . Cell membrane ; Single-pass membrane protein . Detected in intermediate filaments and hemidesmosomes.
• Protein Description: Required for junctional attachments between hypodermis and muscle, and between the apical epithelial surface and the cuticular matrix. Essential for enclosure of the embryo by the hypodermis, hypodermal integrity, embryo elongation, and maintenance of hypodermal morphology in fully elongated embryos..
• Protein Sequence: MRWVPLVLLPLIASAATTYQHRQTYSSLQCRVNDPLSCNQAKSEVCVFVNGQYRCECPVGVSRLADGRCLVVNECARPSLNACHKDAQCVDLAEGYTCRCNSGFADTSPDKVNKPGRQCQKTTNECGAKQTYGVDCDENAACVDTPEGFQCVCQPGYADVSTSISKLPGRKCVESVNECTNGEADCSNNADCFDRADGYECKCRPGFVDASPNVDKYPGRVCNKPKAPEYYGQQSRQPQCSEGSGCGPNEECRFNTAGEKVCQCRRGSVQQSNGVCKVFSQCEQANECDRNAFCSNTYDGPKCQCKDGFLDVSPDPVRLPGRKCQQVRNECADGSHDCSHQAACQDTPTGYICSCNSNCIDVSSRYNLPPGRKCSVAANQCSDKSLNSCDENADCVQLPDGYTCKCFAGYVDVSSNANLPPGRVCTLSTACPAQPTDLVFLIDGSGSIGSYVFQTEVLRFLAEFTELFDIAPQKTRVSVVQYSDQIRHEFGLDNYSDRKSLQNAIRNIEYLTGLTRTGAAIEHVANEAFSERRGARPVGQVSRVAIVITDGRSQDNVTRPSDNARRQDIQLFAVGVTNHVLDAELEEISGSKDRTFHVSGFEDLNTRLRSAIQRVACPHQNNEDTYNKGPCDPSNHNGCDRSLNQVCQQKNGKFVCACPAGFDIHPVTKVCGGDICNPEIATSCPDPEICEKTPFGNWRCTCPADLGWRDRLTGVCKIGEKPVQTSESNDECSPNDVHSCPANSKCEKGAGGEFICKCDAGFQRNGRTNKCEAPGTCDPRMPDSCDARKKEKCLPDGRGAFACMCDRHHKRHPVTDICLIDECAAGVADCDPNAKCTDTDESYICTCNEGFLDKSPEQNKKPGRVCSKQRNECLDGTHNCSMNADCIDLPDGFLCRCKEDFVDISPNPNAFGGIDCRALVNECLITGGHNCHEHAICIDTRDSYKCQCKEGYVDHDELRNPGRTCKKLNQICESGKHECDKNARCVEKGANDYECVCNAGFIDKSPLTHRPGRKCVEPICSDDSKHDCHSAAICEENDSVPEKYTCKCRDGYLDVGAVMGGGKSGRECKELVNECLSASLNSCDAAATCIDLDDGYTCKCPLGSKDESPVPKLPGRSCKGLVNECNIPHLNNCSHFATCIDLEEGYECKCKPEYHDQKPEQPGTECKFIINECLAENLNDCSPNAMCIDKIDGYDCKCKAPFQDEMPSNPGRICRFDECADPKDNDCDKHALCIDTDDSYTCQCKEGFFDEISDPKKPGRVCIGLVIEPQNQSEDPTTPDPNTIKCGNGLCHLDLGEVCVGGATCSCRPGESRDNEKEKCVPTTSIPLVVRVMEYDGEPIQYRTDYSKPDTQAHIEIVDAVKKSVGKIIGKTDVAPRFVTTDVNYITNPKVQNSEWDKGLLGNVSVHLAGKEEVDKCRFYEQFAEIVREMGGRVDRIKLSDDADLDPCKKEEEKKGIPCGNTFCSIELGEECIAGKICGCPKGQKRKDANSPCRAVESWNLPLYVIRDGHEKITYSPSLSNPLNDDHKDLVSRFESGVAQSYDKTPLKGAFVTAEVNEIENPESRKKSWDTGILYNFTSHFVKGSVAEPASVFTDLIDYIQKRNDFEVGKSKLFISPEQLNPFSNCYHSDCHPDAICKEVGKGYTCTCPDGFRDLNPSRPGRNCLSYRGVNECEKPELNECSPHARCIDLDYLYKCECIRPYVNSAVGDALPGSVCSIDYCQDVNYCPLNSTCVNVDEQARCDCKPGFVDLRKSGHLSEAGLGESICRRQSDIDECALGLHNCSAAAICIDKKIGYECQCQEGYEDGNPSQPGRICAASLCGLCNGHGDCIHDALSSNVTCACLDGYTGQFCETAPSNLPLILMTLLALLFLLLTLLCCLYMCARCRCFGARGRSEGSASGQEILGSDYYTIPRAKLARPLYGDEMGDDHAGALAAYLDDGASISSDGSIEEIERRVTTDVTTREVRTTTVRDDDGNIISQSQTISHGNPHETDTEQYGMISSDHYKTSASEAMDAAMSTSASGAAYNQSSGAMMSSASGHKSAYNQGYASDSEDSDAGHAVYDRTTRTNQSHDFEPGADPRTGTERSKREFVTTTKAEEVNYF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
494	N-linked_Glycosylation	RHEFGLDNYSDRKSL HHHHCCCCCCCHHHH		-
556	N-linked_Glycosylation	TDGRSQDNVTRPSDN ECCCCCCCCCCCCCC		-
879	N-linked_Glycosylation	ECLDGTHNCSMNADC CCCCCCCCCCCCCCE		-
1037	N-linked_Glycosylation	SAAICEENDSVPEKY CCEEECCCCCCCCCE		-
1132	N-linked_Glycosylation	CNIPHLNNCSHFATC CCCCCCCCCCCEEEE		-
1271	N-linked_Glycosylation	GLVIEPQNQSEDPTT EEEECCCCCCCCCCC		-
1403	N-linked_Glycosylation	WDKGLLGNVSVHLAG CCCCCCCCEEEEECC		-
1576	N-linked_Glycosylation	WDTGILYNFTSHFVK CCCCHHHHCCHHHCC		-
1730	N-linked_Glycosylation	DVNYCPLNSTCVNVD CCCCCCCCCCEECCC		-
1782	N-linked_Glycosylation	ECALGLHNCSAAAIC HHHHHHCCCCCEEEE		-
1838	N-linked_Glycosylation	IHDALSSNVTCACLD HHHHHHCCCEEEEEC		-
1895	Phosphorylation	CFGARGRSEGSASGQ HHCCCCCCCCCCCCC		19060867
1898	Phosphorylation	ARGRSEGSASGQEIL CCCCCCCCCCCCCCC		19060867
1900	Phosphorylation	GRSEGSASGQEILGS CCCCCCCCCCCCCCC		19060867
1909	Phosphorylation	QEILGSDYYTIPRAK CCCCCCCCCCCCHHH		27067626
1958	Phosphorylation	EEIERRVTTDVTTRE HHHHHHCCCCCCCCE		19530675
1959	Phosphorylation	EIERRVTTDVTTREV HHHHHCCCCCCCCEE		19530675
1998	Phosphorylation	HETDTEQYGMISSDH CCCCHHHHCCCCCCH		27067626
2049	Phosphorylation	KSAYNQGYASDSEDS HHHCCCCCCCCCCCC		19530675
2051	Phosphorylation	AYNQGYASDSEDSDA HCCCCCCCCCCCCCC		19060867
2053	Phosphorylation	NQGYASDSEDSDAGH CCCCCCCCCCCCCCC		19060867
2056	Phosphorylation	YASDSEDSDAGHAVY CCCCCCCCCCCCCEE		19060867

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MUP4_CAEEL !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MUP4_CAEEL !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MUP4_CAEEL !!

Protein-Protein Interaction

Oops, there are no PPI records of MUP4_CAEEL !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.