dbPTM

SORF2_CAEEL - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	SORF2_CAEEL
UniProt AC	Q10122
Protein Name	Suppressor of organelle fusion 2 {ECO:0000303\|PubMed:26783301}
Gene Name	sorf-2 {ECO:0000303\|PubMed:26783301, ECO:0000312\|WormBase:F52C9.1}
Organism	Caenorhabditis elegans.
Sequence Length	1422
Subcellular Localization	Early endosome . Late endosome . Cytoplasm .
Protein Description	Together with sorf-1 negatively regulates the levels of phosphatidylinositol 3-phosphate (PtdIns3P) to enable the conversion of early endosomes to late endosomes. Binds to sorf-1 and the sorf-1-sorf-2 complex likely acts through bec-1, a non-catalytic subunit of phosphatidylinositol 3-kinase (PI3K), to suppress PI3K activity, thereby negatively regulating endosomal PtdIns3P levels..
Protein Sequence	MPEEEFEWNESKLNALSEILTQWAPHDELKLENVILEAKMAWIHESTDAVALEKEFEKLLNTSFDPLMDYEEHQRVKNGVCSPAKSTKLDWITKWANIAEKLSISHINCSKAPHKTINFQRLQILPNMTSILAIAHTEADNVILIYGHTKEGIDFQTVLRHSYSNIPDGSLQTIHFLTKNLLDLYSQLFSRKITAEFKTRHFRCLPSFWLQYDVLAPIFEQFRAPRAPRIPLDEATSNWANRKWENYQYLTYLNDITGRVRGEVHNHPIFPWVCDFSEENGGFRQLNRTKYRLCKGDDQLREMYSREPSHHVPELLSDIGYMVYRARVEPKDNLCRHVRRKWVPEEYPSTMSRMYQWTPDECIPEFYDDPSIFNSCHPDMADLRFPEFVSSPQEFIEWHRKMLEHEEVSMNLHRWIDLVFGFNLAIDNSKNALNLHLCFVEKNRRGLRTTGMVQLFNRPHPIRMPLNYVCYLALDYKSYQPTLRCLVEVRNVYFVSRYKWCKSRILDNDPKLDNYHLKMESFGFGMTSEHRKEPEVEPDEDSHYQIYQKIKKVRRLRHNTYFSSMVSAMEVMAQIVLAPHLAGRFDDPDHIRRCIQLYSYRIPANYRRLFDFLFNTEQDFPDCDEFSFFVSVRLNIPTKILNFSEEFGKCVSLHILRKLDVIPPFSKRSQLIILKEVESLKKSIRLCDHMEQCVVAAFQQLLEDEEACIQSVHRLMPVITRSLSQSALEDLINPMIELIQCETSVKLLDRRFLMHVSICYGTHTFLDLFLPPIVEACASMNCDRSVVAKESIMWLAKRYGPVICAKFISSNVLRIMASCYEAFEMVGLEQQPKAVFNVVLQGDETCSRIESLLSEIVLTYSVTFITVQFLPFCVDLIEQFHKRSSVQLEPGLVSVFRIVELSIRSMSDHQLMNYLEEFIIQKVIYRVLTILLDASFQFSSMRVRIIIICKVCQLLHSITQKIGTENTRIYANQPFKLMFSTFSEIYETDEELRINLRKRPSENTLFEVPLWMVEDVVDKFAKEWGVPFLSSFCDDPAFLIPFVSNSSSSSSPPASIAHSPPSAFTAYSLGGMSSGNRLFSLSASSPVNSVNSLGGLSFCDSGSLSAVWCARVSAAVCGVDNYRFDHLSLCNYTGHQEKIRKLAAISNENSFVSASSDKTVKLWSIKPELDEIGCQWTYQKHTRPVHDITILADNSIASTDGVLHVWDPFRTTLLAQMEWDSKEGSGGNIMRVENVDRHILSAICSLHSTVKLFDSRVGGWTCELKVSPGPGLTRAITVRDKGNKMAVALSNGTLAILDARNGKINALAQTNSTHTVSVNWLSDTRLLVCDADECGIFLETNPRAHIVRKLQDPVSAACLTDNSLVTLQNGTILRVYRNSGELQIETKIRPDELPGTPTAVLPLPLNCSYLIGSSHGAIRLMC

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference	Orthologous Protein Cluster
Oops, there are no PTM records of SORF2_CAEEL !!

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of SORF2_CAEEL !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of SORF2_CAEEL !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of SORF2_CAEEL !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of SORF2_CAEEL !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of SORF2_CAEEL

Related Literatures of Post-Translational Modification