5HT2C_HUMAN - dbPTM
5HT2C_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID 5HT2C_HUMAN
UniProt AC P28335
Protein Name 5-hydroxytryptamine receptor 2C
Gene Name HTR2C
Organism Homo sapiens (Human).
Sequence Length 458
Subcellular Localization Cell membrane
Multi-pass membrane protein .
Protein Description G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances, including ergot alkaloid derivatives, 1-2,5,-dimethoxy-4-iodophenyl-2-aminopropane (DOI) and lysergic acid diethylamide (LSD). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling activates a phosphatidylinositol-calcium second messenger system that modulates the activity of phosphatidylinositol 3-kinase and down-stream signaling cascades and promotes the release of Ca(2+) ions from intracellular stores. Regulates neuronal activity via the activation of short transient receptor potential calcium channels in the brain, and thereby modulates the activation of pro-opiomelacortin neurons and the release of CRH that then regulates the release of corticosterone. Plays a role in the regulation of appetite and eating behavior, responses to anxiogenic stimuli and stress. Plays a role in insulin sensitivity and glucose homeostasis..
Protein Sequence MVNLRNAVHSFLVHLIGLLVWQCDISVSPVAAIVTDIFNTSDGGRFKFPDGVQNWPALSIVIIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVWPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWAISIGVSVPIPVIGLRDEEKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYCLTIYVLRRQALMLLHGHTEEPPGLSLDFLKCCKRNTAEEENSANPNQDQNARRRKKKERRPRGTMQAINNERKASKVLGIVFFVFLIMWCPFFITNILSVLCEKSCNQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSNYLRCNYKVEKKPPVRQIPRVAATALSGRELNVNIYRHTNEPVIEKASDNEPGIEMQVENLELPVNPSSVVSERISSV
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
39N-linked_GlycosylationAIVTDIFNTSDGGRF
HHHEECCCCCCCCCE		38.7211150294
90PhosphorylationKLHNATNYFLMSLAI
HHCHHHHHHHHHHHH		8.1725332170
94PhosphorylationATNYFLMSLAIADML
HHHHHHHHHHHHHHH		19.4525332170
163PhosphorylationIRNPIEHSRFNSRTK
CCCCCCCCCCCHHHH		26.2728842319
271PhosphorylationLKCCKRNTAEEENSA
HHHHHCCCHHHHHCC		39.2127251275
277PhosphorylationNTAEEENSANPNQDQ
CCHHHHHCCCCCHHH		32.4727251275
391AcetylationRCNYKVEKKPPVRQI
CCCCCCCCCCCCCCC		73.837482717
456PhosphorylationSVVSERISSV-----
HHHHHHHCCC-----		31.1310816555
457PhosphorylationVVSERISSV------
HHHHHHCCC------		29.4910816555
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of 5HT2C_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of 5HT2C_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of 5HT2C_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
MPDZ_HUMANMPDZphysical
11150294
MPDZ_HUMANMPDZphysical
9537516
DLG4_HUMANDLG4physical
12006486
LIN7C_HUMANLIN7Cphysical
12006486
APBA1_HUMANAPBA1physical
12006486
TPSN_HUMANTAPBPphysical
28514442
RETR2_HUMANFAM134Aphysical
28514442
KLRG2_HUMANKLRG2physical
28514442
CERS5_HUMANCERS5physical
28514442
S35F1_HUMANSLC35F1physical
28514442
F210B_HUMANFAM210Bphysical
28514442
UB2Q1_HUMANUBE2Q1physical
28514442
CF047_HUMANC6orf47physical
28514442
HMOX2_HUMANHMOX2physical
28514442
IPIL1_HUMANITPRIPL1physical
28514442
RETR3_HUMANFAM134Cphysical
28514442
MTR1L_HUMANGPR50physical
28514442
MBOA5_HUMANLPCAT3physical
28514442
ARL10_HUMANARL10physical
28514442
PDXD1_HUMANPDXDC1physical
28514442
KNTC1_HUMANKNTC1physical
28514442
TM147_HUMANTMEM147physical
28514442
ITPA_HUMANITPAphysical
28514442
ATP8_HUMANATP8physical
28514442
CERS6_HUMANCERS6physical
28514442
CAV1_HUMANCAV1physical
28514442
XPO7_HUMANXPO7physical
28514442
IPO11_HUMANIPO11physical
28514442
LEG3_HUMANLGALS3physical
28514442
S35G2_HUMANSLC35G2physical
28514442
PPAL_HUMANACP2physical
28514442
FITM2_HUMANFITM2physical
28514442
AT2B2_HUMANATP2B2physical
28514442
S39A1_HUMANSLC39A1physical
28514442
LMBD2_HUMANLMBRD2physical
28514442
5NT3A_HUMANNT5C3Aphysical
28514442
EFR3A_HUMANEFR3Aphysical
28514442
GOGA5_HUMANGOLGA5physical
28514442
HEAT3_HUMANHEATR3physical
28514442
D19L4_HUMANDPY19L4physical
28514442
SEC63_HUMANSEC63physical
28514442
PDS5B_HUMANPDS5Bphysical
28514442
BTAF1_HUMANBTAF1physical
28514442
ALG8_HUMANALG8physical
28514442
TNPO3_HUMANTNPO3physical
28514442
RTN4_HUMANRTN4physical
28514442
TBC15_HUMANTBC1D15physical
28514442
RMND1_HUMANRMND1physical
28514442
S19A2_HUMANSLC19A2physical
28514442
S35F2_HUMANSLC35F2physical
28514442
TV23C_HUMANTVP23Cphysical
28514442
ATPB_HUMANATP5Bphysical
28514442
PTH2_HUMANPTRH2physical
28514442
CAND2_HUMANCAND2physical
28514442
CERS2_HUMANCERS2physical
28514442
IPO9_HUMANIPO9physical
28514442
LRC8A_HUMANLRRC8Aphysical
28514442
GLMN_HUMANGLMNphysical
28514442
ACTA_HUMANACTA2physical
28514442
RINT1_HUMANRINT1physical
28514442
EXTL3_HUMANEXTL3physical
28514442
CND3_HUMANNCAPGphysical
28514442
TM9S3_HUMANTM9SF3physical
28514442
SERC1_HUMANSERINC1physical
28514442
FADS1_HUMANFADS1physical
28514442
MRS2_HUMANMRS2physical
28514442
IPO7_HUMANIPO7physical
28514442
MBOA7_HUMANMBOAT7physical
28514442
ANGE1_HUMANANGEL1physical
28514442
TMPPE_HUMANTMPPEphysical
28514442
CND1_HUMANNCAPD2physical
28514442
ECM29_HUMANKIAA0368physical
28514442
CIP2A_HUMANKIAA1524physical
28514442
SFXN5_HUMANSFXN5physical
28514442
CJ035_HUMANC10orf35physical
28514442
TNPO2_HUMANTNPO2physical
28514442
AG10A_HUMANALG10physical
28514442
CAND1_HUMANCAND1physical
28514442
CS025_HUMANC19orf25physical
28514442
MTX1_HUMANMTX1physical
28514442
SNG2_HUMANSYNGR2physical
28514442
GPC5C_HUMANGPRC5Cphysical
28514442
ASPH_HUMANASPHphysical
28514442
AT5F1_HUMANATP5F1physical
28514442
GBB2_HUMANGNB2physical
28514442
EI2BG_HUMANEIF2B3physical
28514442
MPDZ_HUMANMPDZphysical
12682077
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
D00270 Chlorpromazine (USP/INN); Thorazine (TN)
D00283 Clozapine (JAN/USP/INN); Clozaril (TN)
D00403 Levomepromazine (USAN/INN); Methotrimeprazine (USP); Levoprome (TN)
D00454 Olanzapine (JAN/USAN/INN); Zyprexa (TN)
D00563 Mirtazapine (JAN/USAN/INN); Remeron (TN); Reflex (TN)
D00681 Methysergide maleate (USP); Sansert (TN)
D00789 Chlorpromazine hydrochloride (JP16/USP); Sonazine (TN)
D00819 Nefazodone hydrochloride (USAN); Serzone (TN)
D00820 Trazodone hydrochloride (JAN/USP); Desyrel (TN)
D01358 Mianserin hydrochloride (JAN/USAN); Tetramide (TN)
D01477 Opipramol hydrochloride (JAN/USAN); Insidon (TN)
D01520 Levomepromazine hydrochloride (JAN/USAN); Nozinan (TN)
D01902 Dimetotiazine mesilate (JAN); Fonazine mesylate (USAN); Banistyl (TN)
D01939 Ziprasidone hydrochloride hydrate (JAN); Ziprasidone hydrochloride (USAN); Geodon (TN)
D02034 Setiptiline maleate (JAN); Tecipul (TN)
D02100 Ziprasidone mesylate (USAN); Ziprasidone mesylate hydrate; Geodon (TN)
D02248 Levomepromazine maleate (JP16/USAN); Hirnamin (TN)
D02357 Methysergide (USAN/INN)
D02577 Flibanserin (USAN/INN); Ectris (TN)
D02578 Agomelatine (INN); Valdoxan (TN)
D02767 Adatanserin hydrochloride (USAN)
D02893 Amesergide (USAN/INN)
D02995 Asenapine maleate (USAN); Saphris (TN)
D03274 Chlorpromazine hibenzate (JAN); Contomin (TN)
D03506 Cinanserin hydrochloride (USAN)
D04034 Chlorpromazine phenolphthalinate (JAN); Wintermin (TN)
D04320 Glemanserin (USAN/INN); MDL 11939
D04820 Lurasidone hydrochloride (JAN/USAN); SM 13496; Latuda (TN)
D05015 Metrenperone (USAN/INN)
D05395 Pelanserin hydrochloride (USAN)
D05523 Pizotyline (USAN); Pizotifen (INN); Sandomigran (TN)
D05738 Ritanserin (USAN/INN); Tiserton (TN)
D06253 Tropanserin hydrochloride (USAN)
D06613 Lorcaserin hydrochloride (USAN); APD-356; Belviq (TN)
D06623 Olanzapine pamoate (USAN); Olanzapine pamoate monohydrate
D07218 Metergoline (INN)
D07854 Dimetotiazine (INN); Fonazine; Migristene (TN)
D08216 Mianserin (INN); Tolvon (TN)
D08257 Nefazodone (INN)
D08297 Opipramol (INN); Opipramol dura (TN)
D08397 Pizotifen malate; Mosegor (TN); Sandomigran (TN)
D08511 Setiptiline (INN)
D08687 Ziprasidone (INN); Zipradon (TN)
D09819 Chlorpromazine tannate (JAN)
D10170 Tedatioxetine (USAN)
D10171 Tedatioxetine hydrobromide (USAN)
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of 5HT2C_HUMAN

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Related Literatures of Post-Translational Modification

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