CF047_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CF047_HUMAN
• UniProt AC: O95873
• Protein Name: Uncharacterized protein C6orf47
• Gene Name: C6orf47
• Organism: Homo sapiens (Human).
• Sequence Length: 294
• Protein Sequence: MFLRRLGGWLPRPWGRRKPMRPDPPYPEPRRVDSSSENSGSDWDSAPETMEDVGHPKTKDSGALRVSGAASEPSKEEPQVEQLGSKRMDSLKWDQPISSTQESGRLEAGGASPKLRWDHVDSGGTRRPGVSPEGGLSVPGPGAPLEKPGRREKLLGWLRGEPGAPSRYLGGPEECLQISTNLTLHLLELLASALLALCSRPLRAALDTLGLRGPLGLWLHGLLSFLAALHGLHAVLSLLTAHPLHFACLFGLLQALVLAVSLREPNGDEAATDWESEGLEREGEEQRGDPGKGL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
12	Methylation	RLGGWLPRPWGRRKP HCCCCCCCCCCCCCC	37.12	-
34	Phosphorylation	PEPRRVDSSSENSGS CCCCCCCCCCCCCCC	32.67	21082442
35	Phosphorylation	EPRRVDSSSENSGSD CCCCCCCCCCCCCCC	36.89	21082442
36	Phosphorylation	PRRVDSSSENSGSDW CCCCCCCCCCCCCCC	44.76	21082442
39	Phosphorylation	VDSSSENSGSDWDSA CCCCCCCCCCCCCCC	35.31	21082442
41	Phosphorylation	SSSENSGSDWDSAPE CCCCCCCCCCCCCCC	35.04	21082442
45	Phosphorylation	NSGSDWDSAPETMED CCCCCCCCCCCCHHH	41.28	25849741
49	Phosphorylation	DWDSAPETMEDVGHP CCCCCCCCHHHHCCC	25.46	24275569
71	Phosphorylation	LRVSGAASEPSKEEP EEECCCCCCCCCCCC	49.89	26657352
74	Phosphorylation	SGAASEPSKEEPQVE CCCCCCCCCCCCHHH	48.96	23186163
85	Phosphorylation	PQVEQLGSKRMDSLK CHHHHHCCCCCHHCC	26.19	28842319
90	Phosphorylation	LGSKRMDSLKWDQPI HCCCCCHHCCCCCCC	23.62	24275569
98	Phosphorylation	LKWDQPISSTQESGR CCCCCCCCCCCCCCC	33.73	23090842
99	Phosphorylation	KWDQPISSTQESGRL CCCCCCCCCCCCCCC	34.53	23090842
100	Phosphorylation	WDQPISSTQESGRLE CCCCCCCCCCCCCCC	29.57	23090842
103	Phosphorylation	PISSTQESGRLEAGG CCCCCCCCCCCCCCC	21.28	22199227
112	Phosphorylation	RLEAGGASPKLRWDH CCCCCCCCCCCCCEE	26.33	30266825
114	Ubiquitination	EAGGASPKLRWDHVD CCCCCCCCCCCEEEC	48.46	-
131	Phosphorylation	GTRRPGVSPEGGLSV CCCCCCCCCCCCCCC	24.13	25849741
137	Phosphorylation	VSPEGGLSVPGPGAP CCCCCCCCCCCCCCC	29.55	23312004
147	Ubiquitination	GPGAPLEKPGRREKL CCCCCCCCCCHHHHH	61.53	21890473
147	Ubiquitination	GPGAPLEKPGRREKL CCCCCCCCCCHHHHH	61.53	21890473
153	Acetylation	EKPGRREKLLGWLRG CCCCHHHHHHHHHCC	47.39	90231
153	Ubiquitination	EKPGRREKLLGWLRG CCCCHHHHHHHHHCC	47.39	21890473
153	Ubiquitination	EKPGRREKLLGWLRG CCCCHHHHHHHHHCC	47.39	21890473
208	Phosphorylation	PLRAALDTLGLRGPL HHHHHHHHHCCCCHH	24.47	23403867
276	Phosphorylation	EAATDWESEGLEREG HHCCHHHHHHHHHCC	32.48	21815630

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CF047_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CF047_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CF047_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
FGFR3_HUMAN	FGFR3	physical	14667819

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks.";
Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.;
Cell 127:635-648(2006).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-34; SER-35; SER-36;SER-39; SER-41 AND SER-45, AND MASS SPECTROMETRY.
PubMed: 17081983