PCDGD_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PCDGD_HUMAN
• UniProt AC: Q9Y5G3
• Protein Name: Protocadherin gamma-B1
• Gene Name: PCDHGB1
• Organism: Homo sapiens (Human).
• Sequence Length: 927
• Subcellular Localization: Cell membrane; Single-pass type I membrane protein.
• Protein Description: Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain..
• Protein Sequence: MQRAREAEMMKSQVLFPFLLSLFCGAISQQIRYTIPEELANGSRVGKLAKDLGLSVRELPTRKLRVSAEDYFNVSLESGDLLVNGRIDREKICGRKLECALEFETVAENPMNVFHVVVVIQDINDNAPRFVAKGIDLEICESALPGVKFSLDSAQDADVEGNSLKLYTINPNQYFSLSTKESPDGSKYPVLLLEKPLDREHQSSHRLILTAMDGGDPPLSGTTHIWIRVTDANDNAPVFSQEVYRVSLQENVPWGTSVLRVMATDQDEGINAEITYAFLNSPISTSLFNLNPNTGDITTNGTLDFEETSRYVLSVEAKDGGVHTAHCNVQIEIVDENDNAPEVTFMSFSNQIPEDSDLGTVIALIKVRDKDSGQNGMVTCYTQEEVPFKLESTSKNYYKLVIAGALNREQTADYNVTIIATDKGKPALSSRTSITLHISDINDNAPVFHQASYVVHVSENNPPGASIAQVSASDPDLGPNGRVSYSILASDLEPRELLSYVSVSPQSGVVFAQRAFDHEQLRAFELTLQARDQGSPALSANVSLRVLVGDLNDNAPRVLYPALGPDGSALFDMVPRAAEPGYLVTKVVAVDADSGHNAWLSYHVLQASEPGLFSLGLRTGEVRTARALGDRDAARQRLLVAVRDGGQPPLSATATLHLIFADSLQEVLPDLSDRPEPSDPQTELQFYLVVALALISVLFLLAVILAIALRLRRSSSLDTEGCFQTGLCSKSGPGVPPNHSEGTLPYSYNLCIASHSAKTEFNSLNLTPEMAPPQDLLCDDPSMVVCASNEDHKIAYDPSLSSHQAPPNTDWRFSQAQRPGTSGSQNGDDTGTWPNNQFDTEMLQAMILASASEAADGSSTLGGGAGTMGLSARYGPQFTLQHVPDYRQNVYIPGSNATLTNAAGKRDGKAPAGGNGNKKKSGKKEKK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
41	N-linked_Glycosylation	TIPEELANGSRVGKL CCCHHHHCCCHHHHH	62.69	UniProtKB CARBOHYD
55	Phosphorylation	LAKDLGLSVRELPTR HHHHHCCCHHHCCCC	19.82	24719451
73	N-linked_Glycosylation	VSAEDYFNVSLESGD CCHHHHEEEEECCCC	19.08	UniProtKB CARBOHYD
168	Phosphorylation	GNSLKLYTINPNQYF CCEEEEEEECHHHCE	25.39	25693802
176	Phosphorylation	INPNQYFSLSTKESP ECHHHCEEEEECCCC	19.24	25693802
178	Phosphorylation	PNQYFSLSTKESPDG HHHCEEEEECCCCCC	35.91	25693802
179	Phosphorylation	NQYFSLSTKESPDGS HHCEEEEECCCCCCC	44.09	25693802
188	Phosphorylation	ESPDGSKYPVLLLEK CCCCCCCCCEEEEEC	10.56	-
300	N-linked_Glycosylation	NTGDITTNGTLDFEE CCCCCCCCCEECHHH	32.57	UniProtKB CARBOHYD
415	N-linked_Glycosylation	REQTADYNVTIIATD CCCCCCEEEEEEEEC	25.63	UniProtKB CARBOHYD
535	Phosphorylation	LQARDQGSPALSANV EEEHHCCCCCCCCEE	11.02	25072903
539	Phosphorylation	DQGSPALSANVSLRV HCCCCCCCCEEEEEE	21.65	25072903
541	N-linked_Glycosylation	GSPALSANVSLRVLV CCCCCCCEEEEEEEE	22.12	UniProtKB CARBOHYD
585	O-linked_Glycosylation	AEPGYLVTKVVAVDA CCCCEEEEEEEEEEC	18.61	OGP
651	Phosphorylation	DGGQPPLSATATLHL CCCCCCCCCEEEEEE	29.37	-
743	Phosphorylation	PPNHSEGTLPYSYNL CCCCCCCCCCCCCEE	22.10	24719451
746	Phosphorylation	HSEGTLPYSYNLCIA CCCCCCCCCCEEEEE	27.22	25884760
796	Phosphorylation	NEDHKIAYDPSLSSH CCCCCEEECCCCCCC	31.68	25884760
814	Phosphorylation	PNTDWRFSQAQRPGT CCCCCCCCCCCCCCC	18.94	25003641
874	Phosphorylation	TMGLSARYGPQFTLQ CCCCCCCCCCCEEEE	32.64	25884760
879	Phosphorylation	ARYGPQFTLQHVPDY CCCCCCEEEEECCCC	21.91	24961811
886	Phosphorylation	TLQHVPDYRQNVYIP EEEECCCCCCCEEEC	14.18	24927040
891	Phosphorylation	PDYRQNVYIPGSNAT CCCCCCEEECCCCCE	14.67	25884760
895	Phosphorylation	QNVYIPGSNATLTNA CCEEECCCCCEECCC	20.24	24719451
898	Phosphorylation	YIPGSNATLTNAAGK EECCCCCEECCCCCC	38.06	27050516
905	Ubiquitination	TLTNAAGKRDGKAPA EECCCCCCCCCCCCC	42.46	32142685
909	Ubiquitination	AAGKRDGKAPAGGNG CCCCCCCCCCCCCCC	56.33	32142685
918	Ubiquitination	PAGGNGNKKKSGKKE CCCCCCCCCCCCCCC	64.08	32142685

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PCDGD_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PCDGD_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PCDGD_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PCDGE_HUMAN	PCDHGB2	physical	28514442
PCDGG_HUMAN	PCDHGB4	physical	28514442
PCDGF_HUMAN	PCDHGB3	physical	28514442
PCDGK_HUMAN	PCDHGC3	physical	28514442
PCDGB_HUMAN	PCDHGA11	physical	28514442
PCD18_HUMAN	PCDH18	physical	28514442
PCDGL_HUMAN	PCDHGC4	physical	28514442
PCDB2_HUMAN	PCDHB2	physical	28514442
CADH3_HUMAN	CDH3	physical	28514442
PCDGH_HUMAN	PCDHGB5	physical	28514442
PCD10_HUMAN	PCDH10	physical	28514442
OPA3_HUMAN	OPA3	physical	28514442
PCD16_HUMAN	DCHS1	physical	28514442
PCDG7_HUMAN	PCDHGA7	physical	28514442
TMTC2_HUMAN	TMTC2	physical	28514442
F1712_HUMAN	FAM171A2	physical	28514442
F1711_HUMAN	FAM171A1	physical	28514442
PCDG9_HUMAN	PCDHGA9	physical	28514442
CDON_HUMAN	CDON	physical	28514442
CYTSB_HUMAN	SPECC1	physical	28514442
PCDBG_HUMAN	PCDHB16	physical	28514442
PCDH9_HUMAN	PCDH9	physical	28514442
CELR3_HUMAN	CELSR3	physical	28514442
SDK2_HUMAN	SDK2	physical	28514442
PDXL2_HUMAN	PODXL2	physical	28514442
PCDGC_HUMAN	PCDHGA12	physical	28514442
PCDH7_HUMAN	PCDH7	physical	28514442
FAT4_HUMAN	FAT4	physical	28514442
CENPN_HUMAN	CENPN	physical	28514442
PTPRS_HUMAN	PTPRS	physical	28514442
AGRL1_HUMAN	LPHN1	physical	28514442
PCD19_HUMAN	PCDH19	physical	28514442
CELR1_HUMAN	CELSR1	physical	28514442
CC033_HUMAN	C3orf33	physical	28514442
TTC28_HUMAN	TTC28	physical	28514442
AT2B4_HUMAN	ATP2B4	physical	28514442
CELR2_HUMAN	CELSR2	physical	28514442
PTPRK_HUMAN	PTPRK	physical	28514442
TIP_HUMAN	ITFG1	physical	28514442
NEK7_HUMAN	NEK7	physical	28514442
PTPRU_HUMAN	PTPRU	physical	28514442
TNFL9_HUMAN	TNFSF9	physical	28514442
LRFN1_HUMAN	LRFN1	physical	28514442
FREM2_HUMAN	FREM2	physical	28514442
RL23_HUMAN	RPL23	physical	28514442
PCD20_HUMAN	PCDH20	physical	28514442
VGFR3_HUMAN	FLT4	physical	28514442
FACR2_HUMAN	FAR2	physical	28514442
ARL8B_HUMAN	ARL8B	physical	28514442
PKN3_HUMAN	PKN3	physical	28514442
UBP30_HUMAN	USP30	physical	28514442
ALG5_HUMAN	ALG5	physical	28514442
NRP2_HUMAN	NRP2	physical	28514442
AT2B2_HUMAN	ATP2B2	physical	28514442
PTPRF_HUMAN	PTPRF	physical	28514442
FGRL1_HUMAN	FGFRL1	physical	28514442
PKP2_HUMAN	PKP2	physical	28514442
C2C2L_HUMAN	C2CD2L	physical	28514442
CNTN1_HUMAN	CNTN1	physical	28514442
MAN1_HUMAN	LEMD3	physical	28514442
ATP7B_HUMAN	ATP7B	physical	28514442
SDCB1_HUMAN	SDCBP	physical	28514442
NLRX1_HUMAN	NLRX1	physical	28514442
TIM14_HUMAN	DNAJC19	physical	28514442
TPPC5_HUMAN	TRAPPC5	physical	28514442
GPDM_HUMAN	GPD2	physical	28514442
NEK4_HUMAN	NEK4	physical	28514442
ACOT9_HUMAN	ACOT9	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.