CDON_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CDON_HUMAN
• UniProt AC: Q4KMG0
• Protein Name: Cell adhesion molecule-related/down-regulated by oncogenes
• Gene Name: CDON
• Organism: Homo sapiens (Human).
• Sequence Length: 1287
• Subcellular Localization: Cell membrane; Single-pass membrane protein.
• Protein Description: Component of a cell-surface receptor complex that mediates cell-cell interactions between muscle precursor cells. Promotes differentiation of myogenic cells (By similarity)..
• Protein Sequence: MHPDLGPLCTLLYVTLTILCSSVSSDLAPYFTSEPLSAVQKLGGPVVLHCSAQPVTTRISWLHNGKTLDGNLEHVKIHQGTLTILSLNSSLLGYYQCLANNSIGAIVSGPATVSVAVLGDFGSSTKHVITAEEKSAGFIGCRVPESNPKAEVRYKIRGKWLEHSTENYLILPSGNLQILNVSLEDKGSYKCAAYNPVTHQLKVEPIGRKLLVSRPSSDDVHILHPTHSQALAVLSRSPVTLECVVSGVPAPQVYWLKDGQDIAPGSNWRRLYSHLATDSVDPADSGNYSCMAGNKSGDVKYVTYMVNVLEHASISKGLQDQIVSLGATVHFTCDVHGNPAPNCTWFHNAQPIHPSARHLTAGNGLKISGVTVEDVGMYQCVADNGIGFMHSTGRLEIENDGGFKPVIITAPVSAKVADGDFVTLSCNASGLPVPVIRWYDSHGLITSHPSQVLRSKSRKSQLSRPEGLNLEPVYFVLSQAGASSLHIQAVTQEHAGKYICEAANEHGTTQAEASLMVVPFETNTKAETVTLPDAAQNDDRSKRDGSETGLLSSFPVKVHPSAVESAPEKNASGISVPDAPIILSPPQTHTPDTYNLVWRAGKDGGLPINAYFVKYRKLDDGVGMLGSWHTVRVPGSENELHLAELEPSSLYEVLMVARSAAGEGQPAMLTFRTSKEKTASSKNTQASSPPVGIPKYPVVSEAANNNFGVVLTDSSRHSGVPEAPDRPTISTASETSVYVTWIPRANGGSPITAFKVEYKRMRTSNWLVAAEDIPPSKLSVEVRSLEPGSTYKFRVIAINHYGESFRSSASRPYQVVGFPNRFSSRPITGPHIAYTEAVSDTQIMLKWTYIPSSNNNTPIQGFYIYYRPTDSDNDSDYKRDVVEGSKQWHMIGHLQPETSYDIKMQCFNEGGESEFSNVMICETKVKRVPGASEYPVKDLSTPPNSLGSGGNVGPATSPARSSDMLYLIVGCVLGVMVLILMVFIAMCLWKNRQQNTIQKYDPPGYLYQGSDMNGQMVDYTTLSGASQINGNVHGGFLTNGGLSSGYSHLHHKVPNAVNGIVNGSLNGGLYSGHSNSLTRTHVDFEHPHHLVNGGGMYTAVPQIDPLECVNCRNCRNNNRCFTKTNSTFSSSPPPVVPVVAPYPQDGLEMKPLSHVKVPVCLTSAVPDCGQLPEESVKDNVEPVPTQRTCCQDIVNDVSSDGSEDPAEFSRGQEGMINLRIPDHLQLAKSCVWEGDSCAHSETEINIVSWNALILPPVPEGCAEKTMWSPPGIPLDSPTEVLQQPRET

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
88	N-linked_Glycosylation	TLTILSLNSSLLGYY CEEEEECCHHHHHHH	26.61	UniProtKB CARBOHYD
100	N-linked_Glycosylation	GYYQCLANNSIGAIV HHHHHHHCCCCEEEE	29.81	UniProtKB CARBOHYD
180	N-linked_Glycosylation	SGNLQILNVSLEDKG CCCEEEEEEECHHCC	23.98	UniProtKB CARBOHYD
213	Phosphorylation	IGRKLLVSRPSSDDV CCCEEEECCCCCCCC	38.14	24719451
287	N-linked_Glycosylation	VDPADSGNYSCMAGN CCHHHCCCCEECCCC	29.51	UniProtKB CARBOHYD
294	N-linked_Glycosylation	NYSCMAGNKSGDVKY CCEECCCCCCCCCEE	26.28	UniProtKB CARBOHYD
301	Phosphorylation	NKSGDVKYVTYMVNV CCCCCCEEEEEEEHH	9.62	25262027
303	Phosphorylation	SGDVKYVTYMVNVLE CCCCEEEEEEEHHHH	11.65	25262027
304	Phosphorylation	GDVKYVTYMVNVLEH CCCEEEEEEEHHHHH	6.77	25262027
313	Phosphorylation	VNVLEHASISKGLQD EHHHHHHHHCCCHHH	29.33	25262027
315	Phosphorylation	VLEHASISKGLQDQI HHHHHHHCCCHHHHH	20.41	25262027
342	N-linked_Glycosylation	VHGNPAPNCTWFHNA CCCCCCCCCEEEECC	37.65	UniProtKB CARBOHYD
427	N-linked_Glycosylation	DFVTLSCNASGLPVP CEEEEEECCCCCCCC	33.49	UniProtKB CARBOHYD
530	O-linked_Glycosylation	NTKAETVTLPDAAQN CCCEEEEECCCHHHC	39.74	OGP
570	N-linked_Glycosylation	VESAPEKNASGISVP HHCCCCCCCCCCCCC	37.36	UniProtKB CARBOHYD
611	Phosphorylation	GGLPINAYFVKYRKL CCCEEEEEEEEEEEC	12.38	24114839
700	O-linked_Glycosylation	IPKYPVVSEAANNNF CCCCCCCCHHHCCCC	23.04	OGP
718	Phosphorylation	LTDSSRHSGVPEAPD EECCCCCCCCCCCCC	40.14	24043423
728	Phosphorylation	PEAPDRPTISTASET CCCCCCCCEECCCCC	28.58	24043423
730	Phosphorylation	APDRPTISTASETSV CCCCCCEECCCCCEE	22.02	24043423
731	Phosphorylation	PDRPTISTASETSVY CCCCCEECCCCCEEE	30.28	24043423
733	Phosphorylation	RPTISTASETSVYVT CCCEECCCCCEEEEE	41.31	24043423
735	Phosphorylation	TISTASETSVYVTWI CEECCCCCEEEEEEE	22.46	24043423
736	Phosphorylation	ISTASETSVYVTWIP EECCCCCEEEEEEEC	13.85	24043423
738	Phosphorylation	TASETSVYVTWIPRA CCCCCEEEEEEECCC	7.60	24043423
740	Phosphorylation	SETSVYVTWIPRANG CCCEEEEEEECCCCC	10.45	24043423
752	Phosphorylation	ANGGSPITAFKVEYK CCCCCCCEEEEEEEE	29.44	23911959
764	Phosphorylation	EYKRMRTSNWLVAAE EEEECCCCCEEEEEC	18.68	22210691
779	Phosphorylation	DIPPSKLSVEVRSLE CCCHHHCEEEEEECC	21.70	30631047
784	Phosphorylation	KLSVEVRSLEPGSTY HCEEEEEECCCCCEE	42.11	30631047
873	N-linked_Glycosylation	YRPTDSDNDSDYKRD ECCCCCCCCCCCCHH	55.42	UniProtKB CARBOHYD
932	O-linked_Glycosylation	VKRVPGASEYPVKDL CEECCCCCCCCCCCC	43.51	55826335
940	O-linked_Glycosylation	EYPVKDLSTPPNSLG CCCCCCCCCCCCCCC	49.34	OGP
941	Phosphorylation	YPVKDLSTPPNSLGS CCCCCCCCCCCCCCC	50.49	-
945	Phosphorylation	DLSTPPNSLGSGGNV CCCCCCCCCCCCCCC	39.62	-
1064	Phosphorylation	VNGIVNGSLNGGLYS CCCCCCCCCCCCCCC	17.29	28348404
1070	Phosphorylation	GSLNGGLYSGHSNSL CCCCCCCCCCCCCCC	18.84	22461510
1071	Phosphorylation	SLNGGLYSGHSNSLT CCCCCCCCCCCCCCE	34.76	28348404
1074	Phosphorylation	GGLYSGHSNSLTRTH CCCCCCCCCCCEEEE	31.47	28348404
1076	Phosphorylation	LYSGHSNSLTRTHVD CCCCCCCCCEEEEEC	33.85	26699800
1078	Phosphorylation	SGHSNSLTRTHVDFE CCCCCCCEEEEECCC	33.08	28348404
1124	Phosphorylation	NNRCFTKTNSTFSSS CCEEEEECCCCCCCC	31.20	25002506
1126	Phosphorylation	RCFTKTNSTFSSSPP EEEEECCCCCCCCCC	35.74	25002506
1127	Phosphorylation	CFTKTNSTFSSSPPP EEEECCCCCCCCCCC	29.61	25002506
1129	Phosphorylation	TKTNSTFSSSPPPVV EECCCCCCCCCCCEE	29.96	25002506
1130	Phosphorylation	KTNSTFSSSPPPVVP ECCCCCCCCCCCEEC	42.55	25002506
1131	Phosphorylation	TNSTFSSSPPPVVPV CCCCCCCCCCCEECE	39.98	25002506
1142	Phosphorylation	VVPVVAPYPQDGLEM EECEEECCCCCCCCC	12.09	25002506
1153	Phosphorylation	GLEMKPLSHVKVPVC CCCCCCCCCCCCCEE	34.46	25002506

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CDON_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CDON_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CDON_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CTNB1_HUMAN	CTNNB1	physical	12634428
CADH2_HUMAN	CDH2	physical	12634428
BOC_HUMAN	BOC	physical	11782431
CAD15_HUMAN	CDH15	physical	12634428

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.