BOC_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: BOC_HUMAN
• UniProt AC: Q9BWV1
• Protein Name: Brother of CDO
• Gene Name: BOC
• Organism: Homo sapiens (Human).
• Sequence Length: 1114
• Subcellular Localization: Cell membrane ; Single-pass type I membrane protein . Enriched at sites of cell-cell contact.
• Protein Description: Component of a cell-surface receptor complex that mediates cell-cell interactions between muscle precursor cells. Promotes differentiation of myogenic cells..
• Protein Sequence: MLRGTMTAWRGMRPEVTLACLLLATAGCFADLNEVPQVTVQPASTVQKPGGTVILGCVVEPPRMNVTWRLNGKELNGSDDALGVLITHGTLVITALNNHTVGRYQCVARMPAGAVASVPATVTLANLQDFKLDVQHVIEVDEGNTAVIACHLPESHPKAQVRYSVKQEWLEASRGNYLIMPSGNLQIVNASQEDEGMYKCAAYNPVTQEVKTSGSSDRLRVRRSTAEAARIIYPPEAQTIIVTKGQSLILECVASGIPPPRVTWAKDGSSVTGYNKTRFLLSNLLIDTTSEEDSGTYRCMADNGVGQPGAAVILYNVQVFEPPEVTMELSQLVIPWGQSAKLTCEVRGNPPPSVLWLRNAVPLISSQRLRLSRRALRVLSMGPEDEGVYQCMAENEVGSAHAVVQLRTSRPSITPRLWQDAELATGTPPVSPSKLGNPEQMLRGQPALPRPPTSVGPASPQCPGEKGQGAPAEAPIILSSPRTSKTDSYELVWRPRHEGSGRAPILYYVVKHRKVTNSSDDWTISGIPANQHRLTLTRLDPGSLYEVEMAAYNCAGEGQTAMVTFRTGRRPKPEIMASKEQQIQRDDPGASPQSSSQPDHGRLSPPEAPDRPTISTASETSVYVTWIPRGNGGFPIQSFRVEYKKLKKVGDWILATSAIPPSRLSVEITGLEKGTSYKFRVRALNMLGESEPSAPSRPYVVSGYSGRVYERPVAGPYITFTDAVNETTIMLKWMYIPASNNNTPIHGFYIYYRPTDSDNDSDYKKDMVEGDKYWHSISHLQPETSYDIKMQCFNEGGESEFSNVMICETKARKSSGQPGRLPPPTLAPPQPPLPETIERPVGTGAMVARSSDLPYLIVGVVLGSIVLIIVTFIPFCLWRAWSKQKHTTDLGFPRSALPPSCPYTMVPLGGLPGHQASGQPYLSGISGRACANGIHMNRGCPSAAVGYPGMKPQQHCPGELQQQSDTSSLLRQTHLGNGYDPQSHQITRGPKSSPDEGSFLYTLPDDSTHQLLQPHHDCCQRQEQPAAVGQSGVRRAPDSPVLEAVWDPPFHSGPPCCLGLVPVEEVDSPDSCQVSGGDWCPQHPVGAYVGQEPGMQLSPGPLVRVSFETPPLTI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
5	Phosphorylation	---MLRGTMTAWRGM ---CCCCCCCHHCCC	12.62	29083192
7	Phosphorylation	-MLRGTMTAWRGMRP -CCCCCCCHHCCCCH	23.94	29083192
65	N-linked_Glycosylation	VVEPPRMNVTWRLNG EECCCCCEEEEEECC	29.37	UniProtKB CARBOHYD
67	Phosphorylation	EPPRMNVTWRLNGKE CCCCCEEEEEECCEE	10.40	25954137
76	N-linked_Glycosylation	RLNGKELNGSDDALG EECCEECCCCCCCEE	49.35	UniProtKB CARBOHYD
87	Phosphorylation	DALGVLITHGTLVIT CCEEEEEECCEEEEE	15.30	22210691
94	Phosphorylation	THGTLVITALNNHTV ECCEEEEEECCCCCC	20.01	25954137
98	N-linked_Glycosylation	LVITALNNHTVGRYQ EEEEECCCCCCCEEE	32.81	UniProtKB CARBOHYD
189	N-linked_Glycosylation	SGNLQIVNASQEDEG CCCEEECCCCHHCCC	35.19	UniProtKB CARBOHYD
224	Phosphorylation	DRLRVRRSTAEAARI CCEEEEHHHHHHHHE	22.77	22210691
225	Phosphorylation	RLRVRRSTAEAARII CEEEEHHHHHHHHEE	27.06	22210691
233	Phosphorylation	AEAARIIYPPEAQTI HHHHHEECCCCCCEE	15.46	22210691
239	Phosphorylation	IYPPEAQTIIVTKGQ ECCCCCCEEEEECCC	21.51	22210691
274	Phosphorylation	DGSSVTGYNKTRFLL CCCCCCCCCHHHHHE	12.24	-
275	N-linked_Glycosylation	GSSVTGYNKTRFLLS CCCCCCCCHHHHHEE	40.33	UniProtKB CARBOHYD
372	Phosphorylation	SSQRLRLSRRALRVL CHHHHHHHHHHHHHH	17.18	20068231
412	Phosphorylation	QLRTSRPSITPRLWQ EEECCCCCCCHHHHC	37.67	24719451
454	O-linked_Glycosylation	ALPRPPTSVGPASPQ CCCCCCCCCCCCCCC	30.74	OGP
479	Phosphorylation	AEAPIILSSPRTSKT CCCCEEEECCCCCCC	28.08	17081983
480	Phosphorylation	EAPIILSSPRTSKTD CCCEEEECCCCCCCC	18.24	17081983
483	Phosphorylation	IILSSPRTSKTDSYE EEEECCCCCCCCCEE	37.65	-
486	Phosphorylation	SSPRTSKTDSYELVW ECCCCCCCCCEEEEE	29.91	-
488	Phosphorylation	PRTSKTDSYELVWRP CCCCCCCCEEEEECC	26.24	-
517	N-linked_Glycosylation	VKHRKVTNSSDDWTI EECCCCCCCCCCCEE	42.37	UniProtKB CARBOHYD
517 (in isoform 3)	Phosphorylation	-	42.37	24043423
519 (in isoform 3)	Phosphorylation	-	41.48	24043423
520 (in isoform 3)	Phosphorylation	-	56.11	24043423
524 (in isoform 3)	Phosphorylation	-	2.86	24043423
526 (in isoform 3)	Phosphorylation	-	26.50	24043423
536 (in isoform 3)	Phosphorylation	-	2.88	24043423
538 (in isoform 3)	Phosphorylation	-	39.96	24043423
564	Phosphorylation	EGQTAMVTFRTGRRP CCCEEEEEEECCCCC	8.36	24719451
665	Phosphorylation	AIPPSRLSVEITGLE CCCHHHEEEEEECCC	19.32	30631047
669	Phosphorylation	SRLSVEITGLEKGTS HHEEEEEECCCCCCC	23.39	30631047
677	Phosphorylation	GLEKGTSYKFRVRAL CCCCCCCEEEEEEEH	17.62	30631047
693	Phosphorylation	MLGESEPSAPSRPYV HCCCCCCCCCCCCEE	49.08	24275569
696	Phosphorylation	ESEPSAPSRPYVVSG CCCCCCCCCCEEEEC	45.67	24275569
699	Phosphorylation	PSAPSRPYVVSGYSG CCCCCCCEEEECCCC	16.63	24275569
702	Phosphorylation	PSRPYVVSGYSGRVY CCCCEEEECCCCEEE	23.21	24275569
704	Phosphorylation	RPYVVSGYSGRVYER CCEEEECCCCEEEEC	10.63	24275569
725	N-linked_Glycosylation	ITFTDAVNETTIMLK EECCCCCCCCEEEEE	42.49	UniProtKB CARBOHYD
759	N-linked_Glycosylation	YRPTDSDNDSDYKKD ECCCCCCCCCCHHHH	55.42	UniProtKB CARBOHYD
968	Phosphorylation	QQQSDTSSLLRQTHL HCCCCHHHHHHHHCC	33.25	24719451
1109	Phosphorylation	LVRVSFETPPLTI-- EEEEEEECCCCCC--	28.35	28348404

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of BOC_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of BOC_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of BOC_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CTNB1_HUMAN	CTNNB1	physical	12634428
CADH2_HUMAN	CDH2	physical	12634428
LRIF1_HUMAN	LRIF1	physical	16169070
CDON_HUMAN	CDON	physical	11782431
CAD15_HUMAN	CDH15	physical	12634428
KLH24_HUMAN	KLHL24	physical	28514442
OAF_HUMAN	OAF	physical	28514442
FBX2_HUMAN	FBXO2	physical	28514442
ACOX1_HUMAN	ACOX1	physical	28514442
WDR54_HUMAN	WDR54	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.