| UniProt ID | PCDGG_HUMAN | |
|---|---|---|
| UniProt AC | Q9UN71 | |
| Protein Name | Protocadherin gamma-B4 | |
| Gene Name | PCDHGB4 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 923 | |
| Subcellular Localization |
Cell membrane Single-pass type I membrane protein. |
|
| Protein Description | Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.. | |
| Protein Sequence | MGSGAGELGRAERLPVLFLFLLSLFCPALCEQIRYRIPEEMPKGSVVGNLATDLGFSVQELPTRKLRVSSEKPYFTVSAESGELLVSSRLDREEICGKKPACALEFEAVAENPLNFYHVNVEIEDINDHTPKFTQNSFELQISESAQPGTRFILGSAHDADIGSNTLQNYQLSPSDHFSLINKEKSDGSKYPEMVLKTPLDREKQKSYHLTLTALDFGAPPLSSTAQIHVLVTDANDNAPVFSQDVYRVSLSENVYPGTTVLQVTATDQDEGVNAEITFSFSEASQITQFDLNSNTGEITVLNTLDFEEVKEYSIVLEARDGGGMIAQCTVEVEVIDENDNAPEVIFQSLPNLIMEDAELGTHIALLKVRDKDSRHNGEVTCKLEGDVPFKILTSSRNTYKLVTDAVLDREQNPEYNITVTATDRGKPPLSSSSSITLHIGDVNDNAPVFSQSSYIVHVAENNPPGASISQVRASDPDLGPNGQVSYCIMASDLEQRELSSYVSISAESGVVFAQRAFDHEQLRAFELTLQARDQGSPALSANVSLRVLVDDRNDNAPRVLYPALGPDGSALFDMVPHAAEPGYLVTKVVAVDADSGHNAWLSYHVLQASEPGLFSLGLRTGEVRTARALGDRDAVRQRLLVAVRDGGQPPLSATATLHLVFADSLQEVLPDITDRPDPSDLQAELQFYLVVALALISVLFLVAMILAIALRLRRSSSPASWSCFQPGLCVKSESVVPPNYSEGTLPYSYNLCVAHTGKTEFNFLKCSEQLSSGQDILCGDSSGALFPLCNSSELTSHQQAPPNTDWRFSQAQRPGTSGSQNGDDTGTWPNNQFDTEMLQAMILASASEAADGSSTLGGGAGTMGLSARYGPQFTLQHVPDYRQNVYIPGSNATLTNAAGKRDGKAPAGGNGNKKKSGKKEKK | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 3 | Phosphorylation | -----MGSGAGELGR -----CCCCHHHCCH | 24.95 | 21955146 | |
| 70 | Phosphorylation | TRKLRVSSEKPYFTV CCEECCCCCCCEEEE | 46.94 | 17081983 | |
| 74 | Phosphorylation | RVSSEKPYFTVSAES CCCCCCCEEEEEECC | 23.97 | 25907765 | |
| 76 | Phosphorylation | SSEKPYFTVSAESGE CCCCCEEEEEECCCC | 14.01 | 25907765 | |
| 78 | Phosphorylation | EKPYFTVSAESGELL CCCEEEEEECCCCEE | 24.22 | 25907765 | |
| 81 | Phosphorylation | YFTVSAESGELLVSS EEEEEECCCCEEEEE | 36.97 | 25907765 | |
| 87 | Phosphorylation | ESGELLVSSRLDREE CCCCEEEEECCCHHH | 15.09 | 24719451 | |
| 88 | Phosphorylation | SGELLVSSRLDREEI CCCEEEEECCCHHHH | 29.41 | 25907765 | |
| 137 | Phosphorylation | TPKFTQNSFELQISE CCCCCCCEEEEEEEC | 15.41 | 18491316 | |
| 156 | Phosphorylation | GTRFILGSAHDADIG CCEEEECCCCCCCCC | 20.98 | 24043423 | |
| 164 | Phosphorylation | AHDADIGSNTLQNYQ CCCCCCCCCCCCCEE | 27.29 | 24043423 | |
| 166 | Phosphorylation | DADIGSNTLQNYQLS CCCCCCCCCCCEECC | 31.27 | 24043423 | |
| 170 | Phosphorylation | GSNTLQNYQLSPSDH CCCCCCCEECCCHHC | 9.62 | 24043423 | |
| 173 | Phosphorylation | TLQNYQLSPSDHFSL CCCCEECCCHHCCEE | 13.56 | 24043423 | |
| 175 | Phosphorylation | QNYQLSPSDHFSLIN CCEECCCHHCCEEEE | 40.10 | 24043423 | |
| 179 | Phosphorylation | LSPSDHFSLINKEKS CCCHHCCEEEECCCC | 25.56 | 24719451 | |
| 190 | Methylation | KEKSDGSKYPEMVLK CCCCCCCCCCCEEEC | 71.06 | - | |
| 190 | "N6,N6-dimethyllysine" | KEKSDGSKYPEMVLK CCCCCCCCCCCEEEC | 71.06 | - | |
| 394 | Phosphorylation | DVPFKILTSSRNTYK CCCEEEEECCCCCEE | 28.29 | 25072903 | |
| 395 | Phosphorylation | VPFKILTSSRNTYKL CCEEEEECCCCCEEE | 24.69 | 25072903 | |
| 396 | Phosphorylation | PFKILTSSRNTYKLV CEEEEECCCCCEEEE | 25.06 | 25072903 | |
| 399 | Phosphorylation | ILTSSRNTYKLVTDA EEECCCCCEEEEEHH | 22.41 | 25072903 | |
| 400 | Phosphorylation | LTSSRNTYKLVTDAV EECCCCCEEEEEHHH | 13.08 | 25072903 | |
| 404 | Phosphorylation | RNTYKLVTDAVLDRE CCCEEEEEHHHHCCC | 28.77 | 25072903 | |
| 417 | N-linked_Glycosylation | REQNPEYNITVTATD CCCCCCCCEEEEECC | 23.07 | UniProtKB CARBOHYD | |
| 537 | Phosphorylation | LQARDQGSPALSANV EEEHHCCCCCEEEEE | 11.02 | 25072903 | |
| 541 | Phosphorylation | DQGSPALSANVSLRV HCCCCCEEEEEEEEE | 21.65 | 25072903 | |
| 543 | N-linked_Glycosylation | GSPALSANVSLRVLV CCCCEEEEEEEEEEE | 22.12 | UniProtKB CARBOHYD | |
| 653 | Phosphorylation | DGGQPPLSATATLHL CCCCCCCCCEEEEEE | 29.37 | - | |
| 810 | Phosphorylation | PNTDWRFSQAQRPGT CCCCCCCCCCCCCCC | 18.94 | 25003641 | |
| 870 | Phosphorylation | TMGLSARYGPQFTLQ CCCCCCCCCCCEEEE | 32.64 | 25884760 | |
| 875 | Phosphorylation | ARYGPQFTLQHVPDY CCCCCCEEEEECCCC | 21.91 | 24961811 | |
| 882 | Phosphorylation | TLQHVPDYRQNVYIP EEEECCCCCCCEEEC | 14.18 | 24927040 | |
| 887 | Phosphorylation | PDYRQNVYIPGSNAT CCCCCCEEECCCCCE | 14.67 | 25884760 | |
| 891 | Phosphorylation | QNVYIPGSNATLTNA CCEEECCCCCEECCC | 20.24 | 24719451 | |
| 894 | Phosphorylation | YIPGSNATLTNAAGK EECCCCCEECCCCCC | 38.06 | 27050516 | |
| 901 | Ubiquitination | TLTNAAGKRDGKAPA EECCCCCCCCCCCCC | 42.46 | 32142685 | |
| 905 | Ubiquitination | AAGKRDGKAPAGGNG CCCCCCCCCCCCCCC | 56.33 | 32142685 | |
| 914 | Ubiquitination | PAGGNGNKKKSGKKE CCCCCCCCCCCCCCC | 64.08 | 32142685 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of PCDGG_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of PCDGG_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of PCDGG_HUMAN !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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