TMTC2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TMTC2_HUMAN
• UniProt AC: Q8N394
• Protein Name: Transmembrane and TPR repeat-containing protein 2
• Gene Name: TMTC2
• Organism: Homo sapiens (Human).
• Sequence Length: 836
• Subcellular Localization: Membrane ; Multi-pass membrane protein .
• Protein Sequence: MIAELVSSALGLALYLNTLSADFCYDDSRAIKTNQDLLPETPWTHIFYNDFWGTLLTHSGSHKSYRPLCTLSFRLNHAIGGLNPWSYHLVNVLLHAAVTGLFTSFSKILLGDGYWTFMAGLMFASHPIHTEAVAGIVGRADVGASLFFLLSLLCYIKHCSTRGYSARTWGWFLGSGLCAGCSMLWKEQGVTVLAVSAVYDVFVFHRLKIKQILPTIYKRKNLSLFLSISLLIFWGSSLLGARLYWMGNKPPSFSNSDNPAADSDSLLTRTLTFFYLPTKNLWLLLCPDTLSFDWSMDAVPLLKTVCDWRNLHTVAFYTGLLLLAYYGLKSPSVDRECNGKTVTNGKQNANGHSCLSDVEYQNSETKSSFASKVENGIKNDVSQRTQLPSTENIVVLSLSLLIIPFVPATNLFFYVGFVIAERVLYIPSMGFCLLITVGARALYVKVQKRFLKSLIFYATATLIVFYGLKTAIRNGDWQNEEMLYRSGIKVNPAKAWGNLGNVLKSQSKISEAESAYRNALYYRSNMADMLYNLGLLLQENSRFAEALHYYKLAIGSRPTLASAYLNTGIILMNQGRTEEARRTFLKCSEIPDENLKDPHAHKSSVTSCLYNLGKLYHEQGHYEEALSVYKEAIQKMPRQFAPQSLYNMMGEAYMRLSKLPEAEHWYMESLRSKTDHIPAHLTYGKLLALTGRKSEAEKLFLKAIELDPTKGNCYMHYGQFLLEEARLIEAAEMAKKAAELDSTEFDVVFNAAHMLRQASLNEAAEKYYDLAARLRPNYPAALMNLGAILHLNGRLQKAEANYLRALQLKPDDVITQSNLRKLWNIMEKQGLKTSKT

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
72	Phosphorylation	YRPLCTLSFRLNHAI CCCCEEEEEHHCHHH	7.09	24719451
104	Phosphorylation	AVTGLFTSFSKILLG HHHCHHHHHHHHHHC	21.86	24719451
221	N-linked_Glycosylation	PTIYKRKNLSLFLSI HHHHHHCCHHHHHHH	38.61	UniProtKB CARBOHYD
237	Phosphorylation	LLIFWGSSLLGARLY HHHHHCHHHHCCHHH	24.55	24719451
265	Phosphorylation	NPAADSDSLLTRTLT CCCCCCCHHHHHHEE	29.27	24719451
425	Phosphorylation	VIAERVLYIPSMGFC HHHHHHEECCCCCCE	14.13	25884760
453	Phosphorylation	VQKRFLKSLIFYATA HHHHHHHHHHHHHHH	28.92	23663014
457	Phosphorylation	FLKSLIFYATATLIV HHHHHHHHHHHHHHH	8.96	23663014
459	Phosphorylation	KSLIFYATATLIVFY HHHHHHHHHHHHHHH	14.59	23663014
461	Phosphorylation	LIFYATATLIVFYGL HHHHHHHHHHHHHCH	16.80	23663014
644	Phosphorylation	PRQFAPQSLYNMMGE CCCCCCHHHHHHHHH	31.59	24043423
646	Phosphorylation	QFAPQSLYNMMGEAY CCCCHHHHHHHHHHH	13.27	24043423
653	Phosphorylation	YNMMGEAYMRLSKLP HHHHHHHHHHHHCCC	4.39	24043423
694	O-linked_Glycosylation	LALTGRKSEAEKLFL HHHHCCHHHHHHHHH	40.45	30620550

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TMTC2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TMTC2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TMTC2_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of TMTC2_HUMAN !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.