PCDGC_HUMAN - dbPTM
PCDGC_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID PCDGC_HUMAN
UniProt AC O60330
Protein Name Protocadherin gamma-A12
Gene Name PCDHGA12
Organism Homo sapiens (Human).
Sequence Length 932
Subcellular Localization Cell membrane
Single-pass type I membrane protein.
Protein Description Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain..
Protein Sequence MIPARLHRDYKGLVLLGILLGTLWETGCTQIRYSVPEELEKGSRVGDISRDLGLEPRELAERGVRIIPRGRTQLFALNPRSGSLVTAGRIDREELCMGAIKCQLNLDILMEDKVKIYGVEVEVRDINDNAPYFRESELEIKISENAATEMRFPLPHAWDPDIGKNSLQSYELSPNTHFSLIVQNGADGSKYPELVLKRALDREEKAAHHLVLTASDGGDPVRTGTARIRVMVLDANDNAPAFAQPEYRASVPENLALGTQLLVVNATDPDEGVNAEVRYSFRYVDDKAAQVFKLDCNSGTISTIGELDHEESGFYQMEVQAMDNAGYSARAKVLITVLDVNDNAPEVVLTSLASSVPENSPRGTLIALLNVNDQDSEENGQVICFIQGNLPFKLEKSYGNYYSLVTDIVLDREQVPSYNITVTATDRGTPPLSTETHISLNVADTNDNPPVFPQASYSAYIPENNPRGVSLVSVTAHDPDCEENAQITYSLAENTIQGASLSSYVSINSDTGVLYALSSFDYEQFRDLQVKVMARDNGHPPLSSNVSLSLFVLDQNDNAPEILYPALPTDGSTGVELAPRSAEPGYLVTKVVAVDRDSGQNAWLSYRLLKASEPGLFSVGLHTGEVRTARALLDRDALKQSLVVAVQDHGQPPLSATVTLTVAVADSIPQVLADLGSLESPANSETSDLTLYLVVAVAAVSCVFLAFVILLLALRLRRWHKSRLLQASGGGLTGAPASHFVGVDGVQAFLQTYSHEVSLTTDSRKSHLIFPQPNYADMLVSQESFEKSEPLLLSGDSVFSKDSHGLIEQAPPNTDWRFSQAQRPGTSGSQNGDDTGTWPNNQFDTEMLQAMILASASEAADGSSTLGGGAGTMGLSARYGPQFTLQHVPDYRQNVYIPGSNATLTNAAGKRDGKAPAGGNGNKKKSGKKEKK
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
81PhosphorylationLFALNPRSGSLVTAG
EEEECCCCCCEEEEC		33.7127251275
132PhosphorylationDINDNAPYFRESELE
ECCCCCCCCCHHHEE		16.9229052541
136PhosphorylationNAPYFRESELEIKIS
CCCCCCHHHEEEEEC		43.1324702127
265N-linked_GlycosylationGTQLLVVNATDPDEG
CCEEEEEECCCCCCC		29.64UniProtKB CARBOHYD
280PhosphorylationVNAEVRYSFRYVDDK
CCCEEEEEEEECCCC		7.8429496963
397PhosphorylationLPFKLEKSYGNYYSL
CCEEEEECCCCCEEE		28.9723663014
398PhosphorylationPFKLEKSYGNYYSLV
CEEEEECCCCCEEEE		22.0623663014
401PhosphorylationLEKSYGNYYSLVTDI
EEECCCCCEEEEEEE		7.0623663014
402PhosphorylationEKSYGNYYSLVTDIV
EECCCCCEEEEEEEE		10.2623663014
403PhosphorylationKSYGNYYSLVTDIVL
ECCCCCEEEEEEEEE		13.1523663014
406PhosphorylationGNYYSLVTDIVLDRE
CCCEEEEEEEEECCC		25.8723663014
419N-linked_GlycosylationREQVPSYNITVTATD
CCCCCCCEEEEEEEC		28.00UniProtKB CARBOHYD
545N-linked_GlycosylationGHPPLSSNVSLSLFV
CCCCCCCCEEEEEEE		24.83UniProtKB CARBOHYD
569O-linked_GlycosylationILYPALPTDGSTGVE
EEEECCCCCCCCCCE		54.57OGP
628PhosphorylationLHTGEVRTARALLDR
CCCCCHHHHHHHCCH		26.1820068231
753PhosphorylationVQAFLQTYSHEVSLT
HHHHHHHHCCEEEEE		8.6225884760
784PhosphorylationDMLVSQESFEKSEPL
HHEECHHHHHCCCCE		30.9429507054
788PhosphorylationSQESFEKSEPLLLSG
CHHHHHCCCCEEECC		36.9322210691
794PhosphorylationKSEPLLLSGDSVFSK
CCCCEEECCCCCCCC		40.2922210691
797PhosphorylationPLLLSGDSVFSKDSH
CEEECCCCCCCCCCC		28.7022210691
819PhosphorylationPNTDWRFSQAQRPGT
CCCCCCCCCCCCCCC		18.9425003641
879PhosphorylationTMGLSARYGPQFTLQ
CCCCCCCCCCCEEEE		32.6425884760
884PhosphorylationARYGPQFTLQHVPDY
CCCCCCEEEEECCCC		21.9124961811
891PhosphorylationTLQHVPDYRQNVYIP
EEEECCCCCCCEEEC		14.1824927040
896PhosphorylationPDYRQNVYIPGSNAT
CCCCCCEEECCCCCE		14.6725884760
900PhosphorylationQNVYIPGSNATLTNA
CCEEECCCCCEECCC		20.2424719451
903PhosphorylationYIPGSNATLTNAAGK
EECCCCCEECCCCCC		38.0627050516
910UbiquitinationTLTNAAGKRDGKAPA
EECCCCCCCCCCCCC		42.4632142685
914UbiquitinationAAGKRDGKAPAGGNG
CCCCCCCCCCCCCCC		56.3332142685
923UbiquitinationPAGGNGNKKKSGKKE
CCCCCCCCCCCCCCC		64.0832142685
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of PCDGC_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of PCDGC_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of PCDGC_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
A4_HUMANAPPphysical
21832049
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of PCDGC_HUMAN

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Related Literatures of Post-Translational Modification

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