PCD18_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PCD18_HUMAN
• UniProt AC: Q9HCL0
• Protein Name: Protocadherin-18
• Gene Name: PCDH18
• Organism: Homo sapiens (Human).
• Sequence Length: 1135
• Subcellular Localization: Cell membrane; Single-pass type I membrane protein.
• Protein Description: Potential calcium-dependent cell-adhesion protein..
• Protein Sequence: MHQMNAKMHFRFVFALLIVSFNHDVLGKNLKYRIYEEQRVGSVIARLSEDVADVLLKLPNPSTVRFRAMQRGNSPLLVVNEDNGEISIGATIDREQLCQKNLNCSIEFDVITLPTEHLQLFHIEVEVLDINDNSPQFSRSLIPIEISESAAVGTRIPLDSAFDPDVGENSLHTYSLSANDFFNIEVRTRTDGAKYAELIVVRELDRELKSSYELQLTASDMGVPQRSGSSILKISISDSNDNSPAFEQQSYIIQLLENSPVGTLLLDLNATDPDEGANGKIVYSFSSHVSPKIMETFKIDSERGHLTLFKQVDYEITKSYEIDVQAQDLGPNSIPAHCKIIIKVVDVNDNKPEININLMSPGKEEISYIFEGDPIDTFVALVRVQDKDSGLNGEIVCKLHGHGHFKLQKTYENNYLILTNATLDREKRSEYSLTVIAEDRGTPSLSTVKHFTVQINDINDNPPHFQRSRYEFVISENNSPGAYITTVTATDPDLGENGQVTYTILESFILGSSITTYVTIDPSNGAIYALRIFDHEEVSQITFVVEARDGGSPKQLVSNTTVVLTIIDENDNVPVVIGPALRNNTAEITIPKGAESGFHVTRIRAIDRDSGVNAELSCAIVAGNEENIFIIDPRSCDIHTNVSMDSVPYTEWELSVIIQDKGNPQLHTKVLLKCMIFEYAESVTSTAMTSVSQASLDVSMIIIISLGAICAVLLVIMVLFATRCNREKKDTRSYNCRVAESTYQHHPKRPSRQIHKGDITLVPTINGTLPIRSHHRSSPSSSPTLERGQMGSRQSHNSHQSLNSLVTISSNHVPENFSLELTHATPAVEQVSQLLSMLHQGQYQPRPSFRGNKYSRSYRYALQDMDKFSLKDSGRGDSEAGDSDYDLGRDSPIDRLLGEGFSDLFLTDGRIPAAMRLCTEECRVLGHSDQCWMPPLPSPSSDYRSNMFIPGEEFPTQPQQQHPHQSLEDDAQPADSGEKKKSFSTFGKDSPNDEDTGDTSTSSLLSEMSSVFQRLLPPSLDTYSECSEVDRSNSLERRKGPLPAKTVGYPQGVAAWAASTHFQNPTTNCGPPLGTHSSVQPSSKWLPAMEEIPENYEEDDFDNVLNHLNDGKHELMDASELVAEINKLLQDVRQS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
35	Phosphorylation	KNLKYRIYEEQRVGS CCCEEEEEHHHCHHH	12.38	-
48	Phosphorylation	GSVIARLSEDVADVL HHHHHHCCHHHHHHH	26.63	26546556
103	N-linked_Glycosylation	QLCQKNLNCSIEFDV HHHHHCCCCEEEEEE	27.21	UniProtKB CARBOHYD
230	Phosphorylation	VPQRSGSSILKISIS CCCCCCCCEEEEEEE	35.15	24719451
269	N-linked_Glycosylation	GTLLLDLNATDPDEG EEEEEECCCCCCCCC	40.22	UniProtKB CARBOHYD
367	Phosphorylation	SPGKEEISYIFEGDP CCCCCEEEEEEECCC	18.56	27174698
368	Phosphorylation	PGKEEISYIFEGDPI CCCCEEEEEEECCCC	18.45	27174698
377	Phosphorylation	FEGDPIDTFVALVRV EECCCCCEEEEEEEE	22.26	27174698
410	Phosphorylation	GHFKLQKTYENNYLI CEEEEEEEECCCEEE	24.09	26074081
411	Phosphorylation	HFKLQKTYENNYLIL EEEEEEEECCCEEEE	24.56	26074081
415	Phosphorylation	QKTYENNYLILTNAT EEEECCCEEEEEECC	13.50	26074081
419	Phosphorylation	ENNYLILTNATLDRE CCCEEEEEECCCCHH	18.80	26074081
420	N-linked_Glycosylation	NNYLILTNATLDREK CCEEEEEECCCCHHH	27.73	UniProtKB CARBOHYD
422	Phosphorylation	YLILTNATLDREKRS EEEEEECCCCHHHCC	31.12	26074081
429	Phosphorylation	TLDREKRSEYSLTVI CCCHHHCCCCEEEEE	52.53	28509920
431	Phosphorylation	DREKRSEYSLTVIAE CHHHCCCCEEEEEEE	15.38	28509920
432	Phosphorylation	REKRSEYSLTVIAED HHHCCCCEEEEEEEC	17.32	-
434	Phosphorylation	KRSEYSLTVIAEDRG HCCCCEEEEEEECCC	12.15	25332170
559	N-linked_Glycosylation	SPKQLVSNTTVVLTI CHHHEEECCEEEEEE	32.08	UniProtKB CARBOHYD
583	N-linked_Glycosylation	VIGPALRNNTAEITI EECHHHCCCCEEEEE	51.56	UniProtKB CARBOHYD
641	N-linked_Glycosylation	RSCDIHTNVSMDSVP CCCCCCCCCCCCCCC	15.09	UniProtKB CARBOHYD
734	Phosphorylation	EKKDTRSYNCRVAES CCCCCCCCCCEEECH	18.26	22817900
741	Phosphorylation	YNCRVAESTYQHHPK CCCEEECHHHCCCCC	23.76	24961811
742	Phosphorylation	NCRVAESTYQHHPKR CCEEECHHHCCCCCC	20.78	23312004
743	Phosphorylation	CRVAESTYQHHPKRP CEEECHHHCCCCCCC	18.35	25884760
764	Phosphorylation	GDITLVPTINGTLPI CCEEEEEEECCCCCC	21.42	22210691
768	Phosphorylation	LVPTINGTLPIRSHH EEEEECCCCCCCCCC	25.52	28348404
773	Phosphorylation	NGTLPIRSHHRSSPS CCCCCCCCCCCCCCC	25.10	21406692
777	Phosphorylation	PIRSHHRSSPSSSPT CCCCCCCCCCCCCCC	42.09	24275569
778	Phosphorylation	IRSHHRSSPSSSPTL CCCCCCCCCCCCCCC	28.85	26699800
780	Phosphorylation	SHHRSSPSSSPTLER CCCCCCCCCCCCCCC	45.45	21406692
781	Phosphorylation	HHRSSPSSSPTLERG CCCCCCCCCCCCCCC	43.66	21406692
782	Phosphorylation	HRSSPSSSPTLERGQ CCCCCCCCCCCCCCC	26.66	21406692
784	Phosphorylation	SSPSSSPTLERGQMG CCCCCCCCCCCCCCC	43.10	24275569
854	Phosphorylation	PSFRGNKYSRSYRYA CCCCCCCCCHHHHHH	17.20	22199227
855	Phosphorylation	SFRGNKYSRSYRYAL CCCCCCCCHHHHHHC	19.16	22199227
857	Phosphorylation	RGNKYSRSYRYALQD CCCCCCHHHHHHCCC	14.18	22199227
858	Phosphorylation	GNKYSRSYRYALQDM CCCCCHHHHHHCCCH	13.41	22199227
860	Phosphorylation	KYSRSYRYALQDMDK CCCHHHHHHCCCHHH	11.93	22199227
869	Phosphorylation	LQDMDKFSLKDSGRG CCCHHHCCCCCCCCC	40.00	28348404
878	Phosphorylation	KDSGRGDSEAGDSDY CCCCCCCCCCCCCCC	31.97	27732954
885	Phosphorylation	SEAGDSDYDLGRDSP CCCCCCCCCCCCCCH	19.61	25884760
891	Phosphorylation	DYDLGRDSPIDRLLG CCCCCCCCHHHHHHC	23.53	26657352
938	Phosphorylation	CWMPPLPSPSSDYRS CCCCCCCCCCCCCCC	45.13	24719451
940	Phosphorylation	MPPLPSPSSDYRSNM CCCCCCCCCCCCCCC	39.93	27732954
941	Phosphorylation	PPLPSPSSDYRSNMF CCCCCCCCCCCCCCC	41.88	27732954
943	Phosphorylation	LPSPSSDYRSNMFIP CCCCCCCCCCCCCCC	20.21	27732954
990	Phosphorylation	FSTFGKDSPNDEDTG CCCCCCCCCCCCCCC	29.14	28348404
1019	Phosphorylation	FQRLLPPSLDTYSEC HHHHCCCCCCCCHHC	36.62	27251275
1022	Phosphorylation	LLPPSLDTYSECSEV HCCCCCCCCHHCCCC	33.95	25884760
1024	Phosphorylation	PPSLDTYSECSEVDR CCCCCCCHHCCCCCC	33.93	27251275
1027	Phosphorylation	LDTYSECSEVDRSNS CCCCHHCCCCCCCCC	36.28	27251275
1032	Phosphorylation	ECSEVDRSNSLERRK HCCCCCCCCCCHHCC	26.72	26699800
1034	Phosphorylation	SEVDRSNSLERRKGP CCCCCCCCCHHCCCC	32.62	26699800

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PCD18_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PCD18_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PCD18_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of PCD18_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.