PCDGE_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PCDGE_HUMAN
• UniProt AC: Q9Y5G2
• Protein Name: Protocadherin gamma-B2
• Gene Name: PCDHGB2
• Organism: Homo sapiens (Human).
• Sequence Length: 931
• Subcellular Localization: Cell membrane; Single-pass type I membrane protein.
• Protein Description: Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain..
• Protein Sequence: MKASSGRCGLVRWLQVLLPFLLSLFPGALPVQIRYSIPEELAKNSVVGNLAKDLGLSVRDLPARKLRVSAEKEYFTVNPESGDLLVSDRIDREQICGKQPLCVLDFDTVAENPLNIFYIAVIVQDINDNTPLFKQTKINLKIGESTKPGTTFPLDPALDSDVGPNSLQRYHLNDNEYFDLAEKQTPDGRKYPELILKHSLDREEHSLHQLVLTAVDGGDPPQSGTTQIRIKVTDANDNPPVFSQDVYRVTLREDVPPGFFVLQVTATDRDEGINAEITYSFHNVDEQVKHFFNLNEKTGEITTKDDLDFEIASSYTLSIEAKDPGDLAAHCSIQVEILDDNDCAPEVIVTSVSTPLPEDSPPGTVIALIKTRDRDSGENGEVYCQVLGNAKFILKSSSKNYYKLVTDGALDREEIPEYNLTITATDGGKPPLSSSIIVTLHISDVNDNAPVFQQTSYMVHVAENNPPGASIAQISASDPDLGPSGQVSYSIVASDLKPREILSYVSVSAQSGVVFAQRAFDHEQLRAFELTLQARDQGSPALSANVSLRVLVGDLNDNAPRVLYPALGPDGSALFDMVPRAAEPGYLVTKVVAVDADSGHNAWLSYHVLQASEPGLFSLGLRTGEVRTARALGDRDAARQRLLVAVRDGGQPPLSATATLHLIFADSLQEVLPDLSDRREPSDPQAKLQFYLVVALALISVLFFLAVILAISLRLRLSSRSDAWDCFQPGLSSKPGPGVLPNYSEGTLPYSYNLCVASQSAKTEFNFLNITPELVPAQDLVCDNASWEQNTNHGAAGVPFASDTILKQAPPNTDWRFSQAQRPGTSGSQNGDDTGTWPNNQFDTEMLQAMILASASEAADGSSTLGGGAGTMGLSARYGPQFTLQHVPDYRQNVYIPGSNATLTNAAGKRDGKAPAGGNGNKKKSGKKEKK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
57	Phosphorylation	LAKDLGLSVRDLPAR HHHHHCCCHHHCCCC	17.20	24719451
298	Phosphorylation	FFNLNEKTGEITTKD HEECCCCCCCCCCCC	33.59	-
313	Phosphorylation	DLDFEIASSYTLSIE CCCEEEECEEEEEEE	29.55	19690332
314	Phosphorylation	LDFEIASSYTLSIEA CCEEEECEEEEEEEE	17.08	19690332
315	Phosphorylation	DFEIASSYTLSIEAK CEEEECEEEEEEEEC	14.81	19690332
318	Phosphorylation	IASSYTLSIEAKDPG EECEEEEEEEECCHH	15.58	19690332
419	N-linked_Glycosylation	REEIPEYNLTITATD HHHCCCCEEEEEECC	29.10	UniProtKB CARBOHYD
539	Phosphorylation	LQARDQGSPALSANV EEEHHCCCCCCCCEE	11.02	25072903
543	Phosphorylation	DQGSPALSANVSLRV HCCCCCCCCEEEEEE	21.65	25072903
545	N-linked_Glycosylation	GSPALSANVSLRVLV CCCCCCCEEEEEEEE	22.12	UniProtKB CARBOHYD
655	Phosphorylation	DGGQPPLSATATLHL CCCCCCCCCEEEEEE	29.37	-
718	Phosphorylation	ISLRLRLSSRSDAWD HHHHHHHCCCCCHHH	19.78	22210691
719	Phosphorylation	SLRLRLSSRSDAWDC HHHHHHCCCCCHHHH	40.16	22210691
818	Phosphorylation	PNTDWRFSQAQRPGT CCCCCCCCCCCCCCC	18.94	25003641
878	Phosphorylation	TMGLSARYGPQFTLQ CCCCCCCCCCCEEEE	32.64	25884760
883	Phosphorylation	ARYGPQFTLQHVPDY CCCCCCEEEEECCCC	21.91	24961811
890	Phosphorylation	TLQHVPDYRQNVYIP EEEECCCCCCCEEEC	14.18	24927040
895	Phosphorylation	PDYRQNVYIPGSNAT CCCCCCEEECCCCCE	14.67	25884760
899	Phosphorylation	QNVYIPGSNATLTNA CCEEECCCCCEECCC	20.24	24719451
902	Phosphorylation	YIPGSNATLTNAAGK EECCCCCEECCCCCC	38.06	27050516
909	Ubiquitination	TLTNAAGKRDGKAPA EECCCCCCCCCCCCC	42.46	32142685
913	Ubiquitination	AAGKRDGKAPAGGNG CCCCCCCCCCCCCCC	56.33	32142685
922	Ubiquitination	PAGGNGNKKKSGKKE CCCCCCCCCCCCCCC	64.08	32142685

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PCDGE_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PCDGE_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PCDGE_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of PCDGE_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.