dbPTM

CDKA1_ARATH - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	CDKA1_ARATH
UniProt AC	P24100
Protein Name	Cyclin-dependent kinase A-1
Gene Name	CDKA-1
Organism	Arabidopsis thaliana (Mouse-ear cress).
Sequence Length	294
Subcellular Localization	Cytoplasm. Nucleus. Mainly cytoplasmic. Nuclear distribution increases after binding to ICK1/KRP1.
Protein Description	Involved in the control of the cell cycle. Essential for both G1/S and G2/M (mitosis) phase transitions. Functions in cell morphogenesis as well as cell proliferation. Required for cell division (entry into mitosis) of the generative cell in male gametogenesis. Required to trigger guard mother cells (GMC) symmetric divisions at the late stage of stomatal development, probably via the regulation of G1 to S transition in the cell cycle. Promotes divisions in the guard cells (GCs) after the guard mother cells (GMC) symmetric division when in the presence of CYCD3-2. [PubMed: 24687979]
Protein Sequence	MDQYEKVEKIGEGTYGVVYKARDKVTNETIALKKIRLEQEDEGVPSTAIREISLLKEMQHSNIVKLQDVVHSEKRLYLVFEYLDLDLKKHMDSTPDFSKDLHMIKTYLYQILRGIAYCHSHRVLHRDLKPQNLLIDRRTNSLKLADFGLARAFGIPVRTFTHEVVTLWYRAPEILLGSHHYSTPVDIWSVGCIFAEMISQKPLFPGDSEIDQLFKIFRIMGTPYEDTWRGVTSLPDYKSAFPKWKPTDLETFVPNLDPDGVDLLSKMLLMDPTKRINARAALEHEYFKDLGGMP

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
15	Phosphorylation	EKIGEGTYGVVYKAR EECCCCCCEEEEEEE	20.84	16856985
159	Phosphorylation	AFGIPVRTFTHEVVT HHCCCEEECCCCHHH	32.87	23776212
161	Phosphorylation	GIPVRTFTHEVVTLW CCCEEECCCCHHHHH	19.26	19880383
166	Phosphorylation	TFTHEVVTLWYRAPE ECCCCHHHHHHCCCH	19.42	23776212
169	Phosphorylation	HEVVTLWYRAPEILL CCHHHHHHCCCHHHH	10.46	19376835

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
-	K	Ubiquitination	E3 ubiquitin ligase	FBL17	Q8W104	PMID:22199232

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
161	T	Phosphorylation		17369369
Phosphorylation at Thr-161 is important for the kinase activity and substrate binding.

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of CDKA1_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
KRP1_ARATH	ICK1	physical	9753775
CKS1_ARATH	CKS1	physical	17426018
CKS2_ARATH	CKS2	physical	17426018
PSD2A_ARATH	RPN1A	physical	17426018
PSDE_ARATH	AT5G23540	physical	17426018
PSD8A_ARATH	RPN12a	physical	17426018
CCD21_ARATH	CYCD2;1	physical	17426018
KRP6_ARATH	KRP6	physical	17426018
PGMC1_ARATH	AT1G23190	physical	17426018
PSD2B_ARATH	RPN1B	physical	17426018
CDKE1_ARATH	CDKE;1	physical	17426018
CCD41_ARATH	CYCD4;1	physical	17426018
CCD42_ARATH	CYCD4;2	physical	17426018
KRP4_ARATH	KRP4	physical	17426018
PP273_ARATH	emb1796	physical	17426018
CPNA1_ARATH	CPN60A	physical	17426018
VATA_ARATH	VHA-A	physical	17426018
TON1A_ARATH	TON1A	physical	17426018
CCU31_ARATH	CYCP1;1	physical	15197472
CCU11_ARATH	CYCP2;1	physical	15197472
CCU22_ARATH	CYCP3;2	physical	15197472
CCU41_ARATH	CYCP4;1	physical	15197472
CCU43_ARATH	CYCP4;2	physical	15197472
CCU42_ARATH	CYCP4;3	physical	15197472
CCU21_ARATH	cycp3;1	physical	15197472
KRP1_ARATH	ICK1	physical	10758489
KRP2_ARATH	KRP2	physical	10758489
KRP5_ARATH	ICK3	physical	10758489
CCD11_ARATH	CYCD1;1	physical	12857813
CCD41_ARATH	CYCD4;1	physical	12857813
CKS1_ARATH	CKS1	physical	9276444
CCD42_ARATH	CYCD4;2	physical	16408177
HACD_ARATH	PAS2	physical	16698944
CKS1_ARATH	CKS1	physical	20407024
KRP4_ARATH	KRP4	physical	20407024
CCD42_ARATH	CYCD4;2	physical	20407024
KRP1_ARATH	ICK1	physical	20407024
CCD51_ARATH	CYCD5;1	physical	20407024
RBR1_ARATH	RBR1	physical	20407024
WEE1_ARATH	WEE1	physical	20407024
CCD11_ARATH	CYCD1;1	physical	20407024
CCD41_ARATH	CYCD4;1	physical	20407024
KRP6_ARATH	KRP6	physical	20407024
KRP7_ARATH	ICK5	physical	20407024
KRP3_ARATH	ICK6	physical	20407024
CCB12_ARATH	CYC1BAT	physical	20407024
CCD33_ARATH	CYCD3;3	physical	20407024
CCD31_ARATH	CYCD3;1	physical	20407024
CCD21_ARATH	CYCD2;1	physical	20407024
CCA23_ARATH	CYCA2;3	physical	20407024
KRP2_ARATH	KRP2	physical	20407024
KRP5_ARATH	ICK3	physical	20407024
CDKE1_ARATH	CDKE;1	physical	20407024
CKS2_ARATH	CKS2	physical	20407024
CDKA1_ARATH	CDC2	physical	20407024
CKB11_ARATH	CDKB1;1	physical	20407024
CKB12_ARATH	CDKB1;2	physical	20407024
CKB21_ARATH	CDKB2;1	physical	20407024
CDKD1_ARATH	CDKD1;1	physical	20407024
CDKD2_ARATH	CAK4	physical	20407024
CDKD3_ARATH	CDKD1;3	physical	20407024
CDKF1_ARATH	CAK1AT	physical	20407024
CCA11_ARATH	CYCA1;1	physical	20407024
CCA21_ARATH	CYCA2;1	physical	20407024
CCA22_ARATH	CYC3B	physical	20407024
CCA24_ARATH	CYCA2;4	physical	20407024
CCA31_ARATH	CYCA3;1	physical	20407024
CCA32_ARATH	CYCA3;2	physical	20407024
CCA34_ARATH	CYCA3;4	physical	20407024
CCB23_ARATH	CYCB2;3	physical	20407024
CCB31_ARATH	CYCB3;1	physical	20407024
CCD32_ARATH	CYCD3;2	physical	20407024
CCD61_ARATH	CYCD6;1	physical	20407024
CCH11_ARATH	CYCH;1	physical	20407024
DPB_ARATH	DPB	physical	20407024
E2FA_ARATH	E2F3	physical	20407024
APC10_ARATH	APC10	physical	20706207
CKS2_ARATH	CKS2	physical	20706207
CCD41_ARATH	CYCD4;1	physical	20706207
KRP6_ARATH	KRP6	physical	20706207
IF2B_ARATH	EIF2 BETA	physical	20706207
ARAK_ARATH	ARA1	physical	20706207
PGMC1_ARATH	AT1G23190	physical	20706207
PP273_ARATH	emb1796	physical	20706207
UGDH2_ARATH	AT3G29360	physical	20706207
PRS6B_ARATH	RPT3	physical	20706207
PSD1A_ARATH	AT2G32730	physical	20706207
PSMD6_ARATH	AT4G24820	physical	20706207
CFIS2_ARATH	AT4G25550	physical	20706207
PAP1_ARATH	FIB	physical	20706207
RB45A_ARATH	RBP45A	physical	20706207
Y1141_ARATH	AT1G11410	physical	20706207
VAL1_ARATH	HSI2	physical	20706207
UGDH1_ARATH	UGD1	physical	20706207
CKS1_ARATH	CKS1	physical	22098373
KRP1_ARATH	ICK1	physical	22098373
CCD31_ARATH	CYCD3;1	physical	22098373
CDT1A_ARATH	CDT1A	physical	22098373
H11_ARATH	AT1G06760	physical	22098373
CCB12_ARATH	CYC1BAT	physical	22098373
MT2A_ARATH	MT2A	physical	22098373
GPX2_ARATH	GPX2	physical	22098373
GSTF2_ARATH	GSTF2	physical	22098373
MD37E_ARATH	HSC70-1	physical	22098373
KRP6_ARATH	KRP6	physical	23617622
EDE1_ARATH	EDE1	physical	21558460
CKS1_ARATH	CKS1	physical	25521792
CKS2_ARATH	CKS2	physical	25521792
CCD41_ARATH	CYCD4;1	physical	25521792
CCD42_ARATH	CYCD4;2	physical	25521792
KRP3_ARATH	ICK6	physical	25521792
NSF_ARATH	NSF	physical	25521792

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of CDKA1_ARATH

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Site-specific phosphorylation profiling of Arabidopsis proteins bymass spectrometry and peptide chip analysis."; de la Fuente van Bentem S., Anrather D., Dohnal I., Roitinger E.,Csaszar E., Joore J., Buijnink J., Carreri A., Forzani C.,Lorkovic Z.J., Barta A., Lecourieux D., Verhounig A., Jonak C.,Hirt H.; J. Proteome Res. 7:2458-2470(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-161, AND MASSSPECTROMETRY.	18433157 [Abstract]
"T-loop phosphorylation of Arabidopsis CDKA;1 is required for itsfunction and can be partially substituted by an aspartate residue."; Dissmeyer N., Nowack M.K., Pusch S., Stals H., Inze D., Grini P.E.,Schnittger A.; Plant Cell 19:972-985(2007). Cited for: FUNCTION, PHOSPHORYLATION AT THR-161, AND MUTAGENESIS OF THR-161.	17369369 [Abstract]

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