KRP4_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: KRP4_ARATH
• UniProt AC: Q8GYJ3
• Protein Name: Cyclin-dependent kinase inhibitor 4
• Gene Name: KRP4
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 289
• Subcellular Localization: Nucleus, nucleoplasm . Distributed in a ponctuate pattern.
• Protein Description: Binds and inhibits CYCD2-1/CDKA-1 complex kinase activity. May target specifically CDKA-1..
• Protein Sequence: MGKYIRKSKIDGAGAGAGGGGGGGGGGESSIALMDVVSPSSSSSLGVLTRAKSLALQQQQQRCLLQKPSSPSSLPPTSASPNPPSKQKMKKKQQQMNDCGSYLQLRSRRLQKKPPIVVIRSTKRRKQQRRNETCGRNPNPRSNLDSIRGDGSRSDSVSESVVFGKDKDLISEINKDPTFGQNFFDLEEEHTQSFNRTTRESTPCSLIRRPEIMTTPGSSTKLNICVSESNQREDSLSRSHRRRPTTPEMDEFFSGAEEEQQKQFIEKYNFDPVNEQPLPGRFEWTKVDD

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
8	Phosphorylation	MGKYIRKSKIDGAGA CCCCCCHHCCCCCCC	25.62	27531888
29	Phosphorylation	GGGGGGESSIALMDV CCCCCCCCCEEEEEE	30.25	27531888
49	Phosphorylation	SSSLGVLTRAKSLAL CCHHHHHHHHHHHHH	26.61	27531888
53	Phosphorylation	GVLTRAKSLALQQQQ HHHHHHHHHHHHHHH	20.21	25561503
154	Phosphorylation	IRGDGSRSDSVSESV CCCCCCCCCCCCCHH	35.61	25561503
156	Phosphorylation	GDGSRSDSVSESVVF CCCCCCCCCCCHHHC	28.87	25561503
158	Phosphorylation	GSRSDSVSESVVFGK CCCCCCCCCHHHCCC	28.27	25561503
160	Phosphorylation	RSDSVSESVVFGKDK CCCCCCCHHHCCCCH	18.97	25561503
197	Phosphorylation	HTQSFNRTTRESTPC HHHCCCCCCCCCCCC	31.17	25561503
198	Phosphorylation	TQSFNRTTRESTPCS HHCCCCCCCCCCCCC	29.24	25561503
201	Phosphorylation	FNRTTRESTPCSLIR CCCCCCCCCCCCCCC	34.07	25561503
202	Phosphorylation	NRTTRESTPCSLIRR CCCCCCCCCCCCCCC	24.46	25561503
218	Phosphorylation	EIMTTPGSSTKLNIC CEECCCCCCCEEEEE	35.72	25561503
219	Phosphorylation	IMTTPGSSTKLNICV EECCCCCCCEEEEEE	35.16	25561503
245	Phosphorylation	RSHRRRPTTPEMDEF HHHHCCCCCHHHHHH	53.85	23328941
246	Phosphorylation	SHRRRPTTPEMDEFF HHHCCCCCHHHHHHH	21.67	23111157

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of KRP4_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of KRP4_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of KRP4_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RKP_ARATH	RKP	physical	19000158
CCD41_ARATH	CYCD4;1	physical	20407024
CCD11_ARATH	CYCD1;1	physical	20407024
CCD21_ARATH	CYCD2;1	physical	20407024
CCD31_ARATH	CYCD3;1	physical	20407024
CCA24_ARATH	CYCA2;4	physical	20407024
CCA31_ARATH	CYCA3;1	physical	20407024
CCA32_ARATH	CYCA3;2	physical	20407024
CCA34_ARATH	CYCA3;4	physical	20407024
CCD32_ARATH	CYCD3;2	physical	20407024
CCD42_ARATH	CYCD4;2	physical	20407024
CCD51_ARATH	CYCD5;1	physical	20407024
CCD61_ARATH	CYCD6;1	physical	20407024
CCH11_ARATH	CYCH;1	physical	20407024
CDKA1_ARATH	CDC2	physical	20407024
CKB21_ARATH	CDKB2;1	physical	20407024
CDKF1_ARATH	CAK1AT	physical	20407024
CKS1_ARATH	CKS1	physical	20407024
E2FD_ARATH	DEL2	physical	20407024
CDKA1_ARATH	CDC2	physical	20706207
GUN9_ARATH	CEL3	physical	20706207
PRS6B_ARATH	RPT3	physical	20706207
EF115_ARATH	AT5G07310	physical	20706207
EPN1_ARATH	AT5G11710	physical	20706207
IF2B_ARATH	EIF2 BETA	physical	20706207
EIF3H_ARATH	TIF3H1	physical	20706207
EXPA1_ARATH	EXPA1	physical	20706207
FB35_ARATH	AT1G46840	physical	20706207

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.