EPN1_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: EPN1_ARATH
• UniProt AC: Q8VY07
• Protein Name: Clathrin interactor EPSIN 1
• Gene Name: EPSIN1
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 560
• Subcellular Localization: Golgi apparatus . Prevacuolar compartment . Cytoplasm . Cytoplasmic vesicle, clathrin-coated vesicle. Cytoplasm, cytoskeleton . Associated with actin filaments.
• Protein Description: May have a role in transport via clathrin-coated vesicles from the trans-Golgi network to endosomes. Stimulates clathrin assembly (By similarity). Does not seem to bind to phospholipids. Plays an important role in the vacuolar trafficking of soluble cargo proteins at the trans-Golgi network..
• Protein Sequence: MDFMKVFDQTVREIKREVNLKVLKVPEMEQKVLDATDNEPWGPHGTALAEIAQATKKFSECQMVMSVLWTRLSETGKDWRYVYKALAVIDYLISNGSERAVDEIIEHTYQISSLTSFEYVEPNGKDVGINVRKKAENIVALLNNKEKISEIRDKAVANRNKYVGLSSTGITYKSGSSASFGGSFQSGSSNFDSYKDRDSREDKNDYESFQKSRRGVKTEEQSYTSKKSFSRYGSTDHDNLSSGKKSPDSAKHRSYVSAAPSNNDDDFDDFDPRGTSSNKPSTGSANQVDLFGGDLIGDFLDSGPTETSSTNNNENFQEADLFADAAFVSASAQGAEFGSQTQKQVDLFSASEPSVTVSSAPPTVDLFASSESVVSPEAKISIPESMATPNIVDPFAAVPMDNFDGSDPFGAFTSHSASVSTGPQAPSVHGSATNTTSPLSFADSKPQHLQKKDPFQVKSGIWADSLSRGLIDLNITAPKKASLADVGVVGDLSNEDGNKASAASYYSGWSMGAGSGLGKTGLYSTQQQQQQQQQQQAPDISDDFFSSLSNQRYQSGGFKQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
174	Phosphorylation	STGITYKSGSSASFG CCCEEEECCCCCCCC	33.23	25561503
176	Phosphorylation	GITYKSGSSASFGGS CEEEECCCCCCCCCC	29.80	23572148
177	Phosphorylation	ITYKSGSSASFGGSF EEEECCCCCCCCCCC	31.30	24601666
179	Phosphorylation	YKSGSSASFGGSFQS EECCCCCCCCCCCCC	26.77	24601666
183	Phosphorylation	SSASFGGSFQSGSSN CCCCCCCCCCCCCCC	22.08	25561503
186	Phosphorylation	SFGGSFQSGSSNFDS CCCCCCCCCCCCCCC	38.34	25561503
188	Phosphorylation	GGSFQSGSSNFDSYK CCCCCCCCCCCCCCC	27.62	25561503
189	Phosphorylation	GSFQSGSSNFDSYKD CCCCCCCCCCCCCCC	45.07	25561503
228	Phosphorylation	QSYTSKKSFSRYGST HHCCCCCCHHCCCCC	31.99	26658240
232	Phosphorylation	SKKSFSRYGSTDHDN CCCCHHCCCCCCCCC	17.77	23776212
234	Phosphorylation	KSFSRYGSTDHDNLS CCHHCCCCCCCCCCC	23.02	23776212
235	Phosphorylation	SFSRYGSTDHDNLSS CHHCCCCCCCCCCCC	32.75	23776212
241	Phosphorylation	STDHDNLSSGKKSPD CCCCCCCCCCCCCCC	43.21	23776212
242	Phosphorylation	TDHDNLSSGKKSPDS CCCCCCCCCCCCCCH	58.77	23776212
246	Phosphorylation	NLSSGKKSPDSAKHR CCCCCCCCCCHHHCH	37.11	23776212
249	Phosphorylation	SGKKSPDSAKHRSYV CCCCCCCHHHCHHHC	42.47	23776212
482	Phosphorylation	ITAPKKASLADVGVV CCCCCCCCCCCEEEE	32.73	30291188
506	Phosphorylation	KASAASYYSGWSMGA CCCHHHHCCCCCCCC	9.75	30407730
507	Phosphorylation	ASAASYYSGWSMGAG CCHHHHCCCCCCCCC	26.08	30407730
510	Phosphorylation	ASYYSGWSMGAGSGL HHHCCCCCCCCCCCC	15.74	30407730
515	Phosphorylation	GWSMGAGSGLGKTGL CCCCCCCCCCCHHHH	30.25	30407730
555	Phosphorylation	LSNQRYQSGGFKQ-- HHCCCHHCCCCCC--	31.76	27288362

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of EPN1_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of EPN1_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of EPN1_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
VTI11_ARATH	SGR4	physical	16905657
AP1G1_ARATH	GAMMA-ADAPTIN 1	physical	16905657
VSR1_ARATH	VSR1	physical	16905657

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.